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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saco, Jose | 2B | Dunedin Blue Jays | 19 | 12/05/2005 | Santo Domingo | DOM | Right | Right | 6' 0" | 175 lbs | - |
| Saenz, Orlando | RP | Free Agent | 27 | 08/17/1997 | Caracas | VEN | Right | Right | 6' 2" | 205 lbs | - |
| Sakai, Tatsunori | 2B | Fort Myers Mighty Mussels | 21 | 07/03/2003 | Yokohama | JPN | Right | Right | 6' 1" | 195 lbs | - |
| Salmeron, Juan | SP | Tampa Tarpons | 23 | 01/22/2002 | La Romana | DOM | Left | Left | 6' 0" | 190 lbs | - |
| Salmeron, Ricardo | RF | Dunedin Blue Jays | 23 | 04/20/2002 | El Factor | DOM | Left | Left | 6' 4" | 205 lbs | - |
| Salway, Dave | 2B | Fort Myers Mighty Mussels | 19 | 03/11/2006 | Woodmere | USA | Left | Right | 5' 10" | 160 lbs | - |
| Sanchez, Johnny | RP | Free Agent | 25 | 11/20/1999 | Santiago | DOM | Right | Right | 6' 2" | 200 lbs | - |
| Santana, Juan | C | Clearwater Threshers | 22 | 12/25/2002 | Trujillo Alto | PUR | Right | Right | 6' 1" | 205 lbs | - |
| Santana, Manny | 1B | Bradenton Marauders | 22 | 06/28/2003 | Fruit Cove | USA | Right | Right | 6' 2" | 220 lbs | - |
| Sarmiento, Nestor | 3B | Palm Beach Cardinals | 21 | 09/07/2003 | Sosúa | DOM | Right | Right | 6' 1" | 180 lbs | - |
| Scott, David | SP | Bradenton Marauders | 22 | 09/27/2002 | Pharr | USA | Right | Right | 6' 4" | 205 lbs | - |
| Segundo, Javy | SP | St. Lucie Mets | 22 | 04/06/2003 | Santo Domingo | DOM | Right | Left | 6' 2" | 195 lbs | - |
| Serrano, Luis | CF | Free Agent | 28 | 10/30/1996 | Mexico City | MEX | Right | Right | 5' 11" | 180 lbs | - |
| Seto, Yu-wei | SP | Clearwater Threshers | 17 | 11/19/2007 | Sydney | AUS | Left | Left | 6' 1" | 180 lbs | - |
| Sheridan, Jeff | CL | Jupiter Hammerheads | 19 | 06/29/2006 | Wilna | USA | Right | Left | 5' 10" | 170 lbs | - |
| Sisneros, Jesus | SP | Lakeland Flying Tigers | 25 | 02/11/2000 | Valencia | VEN | Right | Right | 5' 11" | 185 lbs | - |
| Skinner, Mark | LF | Dunedin Blue Jays | 18 | 06/22/2007 | Lawrence | USA | Right | Right | 6' 0" | 175 lbs | - |
| Solorzano, Willie | RP | Clearwater Threshers | 21 | 12/11/2003 | Barranquilla | COL | Right | Left | 6' 3" | 200 lbs | - |
| Sommerfeldt, Roger | RP | St. Lucie Mets | 24 | 03/31/2001 | Islandia | USA | Left | Left | 5' 9" | 175 lbs | - |
| Sperry, R.J. | SS | Free Agent | 26 | 03/09/1999 | Thomson | USA | Switch | Right | 6' 1" | 190 lbs | - |
| Stack, Brad | C | Daytona Tortugas | 22 | 07/29/2002 | Kansas City | USA | Switch | Right | 6' 0" | 210 lbs | - |
| Statham, Kelly | C | Dunedin Blue Jays | 23 | 02/08/2002 | Passaic | USA | Right | Right | 6' 0" | 195 lbs | - |
| Stefanopoulos, Brian | SP | Lakeland Flying Tigers | 20 | 07/02/2004 | Vancouver | USA | Right | Left | 6' 1" | 180 lbs | - |
| Sterrett, Walt | RP | Lakeland Flying Tigers | 24 | 05/19/2001 | Bridgeport | USA | Right | Right | 6' 4" | 215 lbs | - |
| Strain, Jesse | RF | Bradenton Marauders | 22 | 03/31/2003 | Grandview | USA | Switch | Left | 6' 2" | 210 lbs | - |
| Stuker, Matt | SP | Dunedin Blue Jays | 23 | 11/19/2001 | El Monte | USA | Left | Left | 6' 3" | 205 lbs | - |
| Sung, Shin-young | C | Fort Myers Mighty Mussels | 19 | 03/24/2006 | Daegu | KOR | Right | Right | 6' 0" | 185 lbs | - |
| Suraci, John | RP | Tampa Tarpons | 22 | 01/12/2003 | Winston-Salem | USA | Right | Right | 6' 1" | 195 lbs | - |
