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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sabino, Sergio | SP | Lake County Captains | 21 | 10/10/2003 | La Romana | DOM | Right | Right | 5' 11" | 185 lbs | - |
| Salais, Alex | RP | Beloit Snappers | 25 | 12/20/1999 | San Luis Potosí | MEX | Left | Right | 6' 2" | 200 lbs | - |
| Salazar, Gustavo | RP | Great Lakes Loons | 23 | 04/03/2002 | Jiguaní | CUB | Right | Left | 5' 11" | 185 lbs | - |
| Salazar, Johnny | RP | Fort Wayne TinCaps | 21 | 04/18/2004 | San Carlos | VEN | Left | Left | 6' 2" | 185 lbs | - |
| Sanchez, Antonio | SS | Lansing Lugnuts | 21 | 07/31/2003 | Villa Vazquez | DOM | Right | Right | 6' 1" | 185 lbs | - |
| Sanders, Chris | SP | Free Agent | 27 | 08/10/1997 | Berwyn | USA | Switch | Right | 6' 10" | 250 lbs | - |
| Sandler, Nick | CF | Peoria Chiefs | 22 | 02/25/2003 | Cleveland | USA | Right | Right | 6' 2" | 190 lbs | - |
| Seda, Manny | SS | Great Lakes Loons | 24 | 03/17/2001 | Villa Riva | DOM | Right | Right | 6' 1" | 180 lbs | - |
| Selzer, Andy | SP | West Michigan Whitecaps | 24 | 04/25/2001 | Elmhurst | USA | Right | Right | 6' 3" | 205 lbs | - |
| Settle, John | 2B | Lansing Lugnuts | 22 | 11/16/2002 | Tacoma | USA | Left | Right | 6' 0" | 195 lbs | - |
| Shadinger, Walter | RP | Beloit Snappers | 22 | 08/18/2002 | New York | USA | Right | Right | 6' 0" | 190 lbs | - |
| Shay, Ezra | SS | Lansing Lugnuts | 21 | 11/02/2003 | McLean | USA | Right | Right | 6' 2" | 190 lbs | - |
| Shepard, Chase | 1B | Lansing Lugnuts | 21 | 11/03/2003 | Bonita Springs | USA | Right | Right | 5' 10" | 175 lbs | - |
| Shultz, Matt | RP | Quad Cities River Bandits | 23 | 10/08/2001 | Broken Arrow | USA | Right | Right | 5' 9" | 175 lbs | - |
| Siguenza, Ramon | LF | South Bend Cubs | 20 | 01/31/2005 | Santo Domingo | DOM | Right | Right | 6' 2" | 190 lbs | - |
| Simmons, Steve | SP | Quad Cities River Bandits | 22 | 08/11/2002 | Hobart | USA | Left | Left | 6' 2" | 200 lbs | - |
| Slycord, Phil | SP | Dayton Dragons | 24 | 03/14/2001 | New York | USA | Left | Left | 6' 0" | 200 lbs | $1,800,000 |
| Smart, Greg | LF | Quad Cities River Bandits | 24 | 10/26/2000 | Gatesville | USA | Right | Left | 6' 1" | 200 lbs | $2,200,000 |
| Smith, Danny | RP | Beloit Snappers | 25 | 06/09/2000 | Belize City | BLZ | Right | Right | 6' 2" | 205 lbs | - |
| Smith, Jeff | 3B | Lansing Lugnuts | 19 | 09/19/2005 | Medford | USA | Right | Right | 6' 0" | 185 lbs | - |
| Smith, Jesse | SP | Cedar Rapids Kernels | 23 | 07/02/2001 | Maquoketa | USA | Switch | Right | 6' 2" | 210 lbs | $2,600,000 |
| Smith, Jim | RP | Free Agent | 26 | 04/29/1999 | Sawgrass | USA | Right | Right | 6' 4" | 215 lbs | - |
| Smith, Kevin | SS | Peoria Chiefs | 22 | 12/04/2002 | Honolulu | USA | Right | Right | 5' 11" | 185 lbs | - |
| Smothers, Greg | C | Lake County Captains | 24 | 05/04/2001 | Central Point | USA | Right | Right | 6' 0" | 210 lbs | - |
| Solano, Jorge | RP | Lansing Lugnuts | 22 | 01/20/2003 | Teays Valley | USA | Left | Right | 6' 4" | 205 lbs | - |
| Soto, Omar | 2B | Dayton Dragons | 24 | 12/09/2000 | Ubilla | DOM | Right | Right | 6' 0" | 200 lbs | - |
| Sowers, Greg | C | Free Agent | 26 | 08/10/1998 | Gulfport | USA | Switch | Right | 6' 0" | 205 lbs | - |
| Spear, Cody | SP | Quad Cities River Bandits | 24 | 02/20/2001 | Lawrence Township | USA | Right | Right | 6' 2" | 205 lbs | - |
| Spencer, Drew | SP | Lansing Lugnuts | 22 | 05/23/2003 | San Antonio | USA | Left | Left | 5' 10" | 175 lbs | - |
| Spinks, John | LF | Peoria Chiefs | 22 | 01/10/2003 | Old Fig Garden | USA | Left | Right | 6' 3" | 205 lbs | - |
| Spurrier, Justin | RP | Peoria Chiefs | 24 | 01/03/2001 | Oak Park | USA | Right | Right | 5' 10" | 180 lbs | - |
| Stephan, Dustin | 3B | Lansing Lugnuts | 22 | 09/01/2002 | Austin | USA | Right | Right | 6' 1" | 195 lbs | - |
| Stephenson, Tim | RP | Lansing Lugnuts | 22 | 11/06/2002 | Houston | USA | Left | Left | 6' 0" | 185 lbs | - |
| Street, Frank | SP | Peoria Chiefs | 24 | 07/24/2000 | Milledgeville | USA | Left | Left | 6' 1" | 200 lbs | $3,400,000 |
| Stroud, Cliff | SP | Wisconsin Timber Rattlers | 25 | 06/07/2000 | Brooklyn | USA | Right | Right | 6' 1" | 195 lbs | $1,700,000 |
| Strub, Elliott | LF | Lansing Lugnuts | 20 | 09/23/2004 | New Bedford | USA | Left | Left | 6' 4" | 205 lbs | - |
| Stuart, David | SP | Lake County Captains | 23 | 07/24/2001 | Corinth | USA | Right | Right | 6' 1" | 195 lbs | $4,000,000 |
| Suarez, Julio | 3B | Free Agent | 24 | 05/19/2001 | Santo Domingo | DOM | Left | Right | 6' 2" | 190 lbs | - |
| Sumler, Jaylen | C | Free Agent | 28 | 03/19/1997 | Centennial | USA | Right | Right | 6' 2" | 205 lbs | - |
| Sweet, Chris | 2B | West Michigan Whitecaps | 19 | 08/07/2005 | Wichita | USA | Right | Right | 6' 0" | 180 lbs | - |
| Swiderski, Josh | CL | Cedar Rapids Kernels | 24 | 02/09/2001 | Monroe Township, Gloucester County | USA | Left | Left | 5' 10" | 180 lbs | - |
| Swift, Jake | 1B | Free Agent | 27 | 08/07/1997 | Abilene | USA | Right | Right | 6' 2" | 235 lbs | - |
