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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saavedra, Edwin | SP | Free Agent | 25 | 10/13/2000 | San Pedro de Macorís | DOM | Switch | Right | 6' 0" | 200 lbs | - |
| Sakai, Tatsunori | CF | Wichita Wind Surge | 23 | 07/03/2003 | Yokohama | JPN | Right | Right | 6' 1" | 200 lbs | - |
| Salazar, Gustavo | SP | Frisco RoughRiders | 24 | 04/03/2002 | Jiguaní | CUB | Right | Left | 5' 11" | 185 lbs | $740,000 |
| Salazar, Johnny | SP | San Antonio Missions | 22 | 04/18/2004 | San Carlos | VEN | Left | Left | 6' 2" | 190 lbs | - |
| Salazar, Pedro | C | Frisco RoughRiders | 24 | 04/12/2002 | Bajos de Haina | DOM | Left | Right | 6' 2" | 195 lbs | - |
| Saldana, Carlos | C | Arkansas Travelers | 24 | 11/23/2001 | Barquisimeto | VEN | Right | Right | 5' 10" | 200 lbs | - |
| Salway, Dave | SS | Wichita Wind Surge | 20 | 03/11/2006 | Woodmere | USA | Left | Right | 5' 10" | 160 lbs | - |
| Sambrano, Dave | RF | Wichita Wind Surge | 28 | 01/18/1998 | San Cristóbal | DOM | Right | Left | 5' 10" | 195 lbs | $1,740,000 |
| Sanchez, Jose | SP | Amarillo Sod Poodles | 24 | 01/26/2002 | Seven Trees | USA | Right | Right | 6' 2" | 200 lbs | - |
| Sanchez, Vicente | SP | San Antonio Missions | 26 | 05/09/2000 | Mao | DOM | Right | Right | 6' 4" | 215 lbs | - |
| Sanders, Mark | RP | Northwest Arkansas Naturals | 22 | 03/09/2004 | South Salt Lake | USA | Right | Right | 6' 0" | 180 lbs | - |
| Sandler, Nick | LF | Springfield Cardinals | 23 | 02/25/2003 | Cleveland | USA | Right | Right | 6' 2" | 195 lbs | - |
| Santos, William | 1B | Free Agent | 26 | 04/17/2000 | Santo Domingo | DOM | Left | Left | 6' 2" | 210 lbs | - |
| Sarmiento, Josh | C | Amarillo Sod Poodles | 26 | 10/03/1999 | Crowley | USA | Right | Right | 6' 1" | 215 lbs | $740,000 |
| Sas, Matt | LF | Northwest Arkansas Naturals | 20 | 10/02/2005 | Plainfield | USA | Right | Right | 6' 2" | 185 lbs | - |
| Satterlee, Jonathan | 2B | Wichita Wind Surge | 23 | 04/07/2003 | Milwaukee | USA | Switch | Right | 6' 2" | 195 lbs | - |
| Schaffert, Adam | C | Free Agent | 27 | 04/14/1999 | Rochester | USA | Right | Right | 5' 10" | 190 lbs | - |
| Scheffler, Jason | SP | Free Agent | 28 | 01/14/1998 | Los Angeles | USA | Left | Right | 6' 1" | 205 lbs | - |
| Schultz, Steve | RF | San Antonio Missions | 24 | 10/02/2001 | Mesa | USA | Right | Left | 6' 1" | 195 lbs | - |
| Schuman, Bryan | 2B | Midland RockHounds | 20 | 12/08/2005 | Lindsborg | USA | Right | Right | 6' 0" | 180 lbs | - |
| Schwanz, Lance | SP | San Antonio Missions | 25 | 04/11/2001 | Bourg | USA | Right | Right | 5' 9" | 180 lbs | - |
| Schwartz, Joe | RP | Arkansas Travelers | 28 | 11/21/1997 | Opportunity | USA | Left | Left | 5' 11" | 190 lbs | $740,000 |
| Scoggins, Josh | LF | Free Agent | 27 | 02/25/1999 | Natick | USA | Left | Right | 6' 1" | 210 lbs | - |
| Scott, Rich | CF | Northwest Arkansas Naturals | 22 | 06/03/2004 | Ahoskie | USA | Right | Right | 6' 1" | 180 lbs | - |
| Servin, Alex | C | Midland RockHounds | 23 | 12/23/2002 | Guanabacoa | CUB | Right | Right | 6' 2" | 220 lbs | - |
| Shaw, Scott | RP | Amarillo Sod Poodles | 23 | 09/27/2002 | Metairie | USA | Left | Left | 6' 0" | 190 lbs | - |
| Shroyer, Mike | RP | Free Agent | 26 | 05/23/2000 | Woodstock | USA | Right | Right | 5' 10" | 190 lbs | - |
| Shultz, Matt | SP | Free Agent | 24 | 10/08/2001 | Broken Arrow | USA | Right | Right | 5' 9" | 185 lbs | - |
| Sidwell, Perry | RP | Corpus Christi Hooks | 24 | 03/10/2002 | Troy | USA | Right | Right | 6' 0" | 190 lbs | - |
| Simmons, Stephen | SP | Free Agent | 26 | 12/25/1999 | Ashland | USA | Right | Right | 6' 0" | 200 lbs | - |
| Skelton, Greg | RF | Frisco RoughRiders | 24 | 02/02/2002 | Catlin | USA | Left | Left | 6' 1" | 200 lbs | - |
| Slaughter, Josh | SS | Amarillo Sod Poodles | 27 | 06/04/1999 | Irondequoit | USA | Right | Right | 6' 0" | 190 lbs | $740,000 |
| Smart, Greg | CF | Frisco RoughRiders | 25 | 10/26/2000 | Gatesville | USA | Right | Left | 6' 1" | 200 lbs | $740,000 |
| Smith, Billy | RP | Amarillo Sod Poodles | 24 | 05/18/2002 | Robinson | USA | Left | Right | 6' 0" | 190 lbs | - |
| Smith, Joey | 2B | Free Agent | 26 | 08/19/1999 | Smithfield | USA | Right | Right | 6' 1" | 200 lbs | - |
| Smith, John | SP | Free Agent | 25 | 01/03/2001 | Marshall | USA | Right | Right | 6' 2" | 205 lbs | - |
| Smith, Josh | 2B | Free Agent | 27 | 10/10/1998 | Fairview | USA | Right | Right | 6' 0" | 185 lbs | - |
| Smith, Josh | 1B | Midland RockHounds | 23 | 08/07/2002 | Viera East | USA | Right | Right | 6' 0" | 210 lbs | - |
| Smith, Nick | LF | Free Agent | 26 | 07/01/2000 | Huntingburg | USA | Right | Right | 6' 1" | 210 lbs | - |
| Smith, Paul | RP | Springfield Cardinals | 24 | 03/07/2002 | Washington | USA | Right | Left | 6' 0" | 195 lbs | $740,000 |
| Smith, Zachary | LF | Midland RockHounds | 23 | 06/18/2003 | Macclenny | USA | Right | Right | 6' 1" | 200 lbs | - |
| Smithley, Mike | LF | Free Agent | 25 | 12/06/2000 | Smithfield | USA | Left | Right | 6' 2" | 215 lbs | - |
| Soberano, Luis | RF | Northwest Arkansas Naturals | 26 | 11/16/1999 | Santo Domingo | DOM | Right | Right | 6' 2" | 200 lbs | $740,000 |
| Solano, Guadalupe | RF | Wichita Wind Surge | 28 | 09/06/1997 | Palmira | CUB | Left | Right | 6' 3" | 215 lbs | - |
| Sorola, Antonio | RP | Free Agent | 27 | 12/17/1998 | Maracaibo | VEN | Left | Left | 6' 0" | 200 lbs | - |
| Soto, Jose | RP | Tulsa Drillers | 22 | 04/22/2004 | Brooklyn | USA | Right | Right | 6' 1" | 180 lbs | - |
| Soto, Miguel | CF | Northwest Arkansas Naturals | 23 | 11/06/2002 | Bajos de Haina | DOM | Right | Right | 6' 0" | 200 lbs | - |
| Spear, Cody | SP | Free Agent | 25 | 02/20/2001 | Lawrence Township | USA | Right | Right | 6' 2" | 205 lbs | - |
| Spina, Adam | SP | Corpus Christi Hooks | 21 | 10/25/2004 | Miramar Beach | USA | Switch | Right | 5' 11" | 180 lbs | - |
| Spletter, Bill | C | Free Agent | 26 | 07/04/2000 | Dallas | USA | Right | Right | 6' 0" | 205 lbs | - |
| Stack, Brad | C | Northwest Arkansas Naturals | 23 | 07/29/2002 | Kansas City | USA | Switch | Right | 6' 0" | 215 lbs | - |
| Statham, Craig | SP | Wichita Wind Surge | 30 | 04/23/1996 | Arlington | USA | Left | Right | 5' 11" | 190 lbs | $740,000 |
| Steinmetz, Fred | SP | Free Agent | 26 | 10/20/1999 | Joliet | USA | Right | Right | 6' 0" | 200 lbs | - |
| Stephens, James | SP | Free Agent | 26 | 06/14/2000 | Warren | USA | Right | Right | 6' 1" | 195 lbs | - |
| Storm, Kyle | SP | Midland RockHounds | 26 | 03/04/2000 | New Berlin | USA | Right | Right | 6' 1" | 200 lbs | - |
| Stromquist, Rick | C | Free Agent | 25 | 08/20/2000 | Denver | USA | Right | Right | 6' 1" | 210 lbs | - |
| Stuckwisch, Josh | RP | Corpus Christi Hooks | 22 | 06/10/2004 | Seaside | USA | Switch | Right | 6' 2" | 190 lbs | - |
| Sutherland, Gregg | SP | Frisco RoughRiders | 22 | 08/05/2003 | Houston | USA | Left | Left | 5' 10" | 175 lbs | - |
| Sutton, Brian | 1B | Frisco RoughRiders | 25 | 02/19/2001 | Inkster | USA | Right | Right | 6' 1" | 215 lbs | - |
| Sweet, Jesse | 1B | Corpus Christi Hooks | 21 | 03/23/2005 | University Park | USA | Right | Right | 6' 4" | 200 lbs | - |
| Szymoniak, Jamie | RP | Tulsa Drillers | 24 | 02/23/2002 | Mariemont | USA | Switch | Right | 6' 1" | 190 lbs | - |
