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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saathoff, Jason | C | Down East Wood Ducks | 21 | 05/18/2004 | Waterford Township | USA | Right | Right | 6' 1" | 215 lbs | - |
| Salazar, Gustavo | SP | Fredericksburg Nationals | 23 | 04/03/2002 | Jiguaní | CUB | Right | Left | 5' 11" | 185 lbs | - |
| Sanchez, Carlos | SP | Myrtle Beach Pelicans | 21 | 09/19/2004 | Santo Domingo | DOM | Left | Left | 6' 2" | 190 lbs | - |
| Sanchez, Raul | RP | Myrtle Beach Pelicans | 20 | 09/27/2005 | Castaic | USA | Left | Left | 6' 1" | 180 lbs | - |
| Santana, Dennis | 3B | Carolina Mudcats | 23 | 03/09/2002 | Aloha | USA | Right | Right | 6' 0" | 195 lbs | - |
| Schwanz, Lance | CL | Fredericksburg Nationals | 24 | 04/11/2001 | Bourg | USA | Right | Right | 5' 9" | 180 lbs | - |
| Schwerdtfeger, Jason | 3B | Kannapolis Cannon Ballers | 22 | 04/13/2003 | Downingtown | USA | Switch | Right | 6' 0" | 190 lbs | - |
| Shadrick, Glenn | RP | Down East Wood Ducks | 22 | 02/20/2003 | Camanche | USA | Right | Right | 6' 2" | 195 lbs | - |
| Sheppard, Ron | LF | Columbia Fireflies | 24 | 10/11/2001 | Eustis | USA | Right | Right | 6' 3" | 220 lbs | - |
| Sidwell, Perry | RP | Fayetteville Woodpeckers | 23 | 03/10/2002 | Troy | USA | Right | Right | 6' 0" | 190 lbs | - |
| Sieczka, Ben | LF | Charleston RiverDogs | 21 | 07/13/2004 | Upper Arlington | USA | Right | Right | 6' 0" | 185 lbs | - |
| Sierra, Daniel | RP | Down East Wood Ducks | 22 | 12/12/2003 | Temblador | VEN | Left | Left | 5' 9" | 170 lbs | - |
| Skelton, Greg | RF | Down East Wood Ducks | 23 | 02/02/2002 | Catlin | USA | Left | Left | 6' 1" | 200 lbs | - |
| Smith, Jimmy | SS | Lynchburg Hillcats | 19 | 10/01/2006 | Uhrichsville | USA | Switch | Right | 6' 0" | 175 lbs | - |
| Smith, Jon | RF | Delmarva Shorebirds | 22 | 10/01/2003 | Brossard | CAN | Right | Right | 6' 0" | 205 lbs | - |
| Smith, Zack | SP | Charleston RiverDogs | 25 | 08/08/2000 | Elk Plain | USA | Left | Left | 5' 10" | 190 lbs | - |
| Solis, Freddy | C | Charleston RiverDogs | 19 | 05/19/2006 | Hidden Hills | USA | Right | Right | 6' 0" | 180 lbs | - |
| Soto, Miguel | CF | Columbia Fireflies | 23 | 11/06/2002 | Bajos de Haina | DOM | Right | Right | 6' 0" | 200 lbs | - |
| Sparks, Travis | SP | Lynchburg Hillcats | 19 | 04/08/2006 | Santa Clarita | USA | Right | Right | 6' 2" | 190 lbs | - |
| Spina, Adam | SP | Fayetteville Woodpeckers | 21 | 10/25/2004 | Miramar Beach | USA | Switch | Right | 5' 11" | 175 lbs | - |
| Stack, Brad | C | Columbia Fireflies | 23 | 07/29/2002 | Kansas City | USA | Switch | Right | 6' 0" | 215 lbs | - |
| Sweet, Jesse | 2B | Fayetteville Woodpeckers | 20 | 03/23/2005 | University Park | USA | Right | Right | 6' 4" | 200 lbs | - |
