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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saidana, Omar | SP | Augusta GreenJackets | 20 | 04/14/2005 | Long Beach | USA | Right | Right | 6' 0" | 175 lbs | - |
| Salazar, Pedro | C | Down East Wood Ducks | 23 | 04/12/2002 | Bajos de Haina | DOM | Left | Right | 6' 2" | 195 lbs | - |
| Sales, Josh | C | Salem Red Sox | 22 | 11/11/2003 | The Acreage | USA | Right | Right | 6' 0" | 200 lbs | - |
| Sanchez, Carlos | RP | Myrtle Beach Pelicans | 21 | 09/19/2004 | Santo Domingo | DOM | Left | Left | 6' 2" | 190 lbs | - |
| Sanchez, Raul | RP | Myrtle Beach Pelicans | 20 | 09/27/2005 | Castaic | USA | Left | Left | 6' 1" | 180 lbs | - |
| Sanders, Mark | RP | Columbia Fireflies | 22 | 03/09/2004 | South Salt Lake | USA | Right | Right | 6' 0" | 180 lbs | - |
| Schumpert, Brendan | SP | Delmarva Shorebirds | 21 | 12/29/2004 | Crestwood | USA | Switch | Left | 5' 10" | 180 lbs | - |
| Scott, Danny | 2B | Delmarva Shorebirds | 23 | 06/03/2002 | Glendora | USA | Right | Right | 6' 0" | 185 lbs | - |
| Scott, Mike | RP | Charleston RiverDogs | 23 | 12/10/2002 | Lochearn | USA | Right | Right | 6' 1" | 195 lbs | - |
| Scott, Rich | CF | Columbia Fireflies | 21 | 06/03/2004 | Ahoskie | USA | Right | Right | 6' 1" | 180 lbs | - |
| Shadrick, Glenn | RP | Down East Wood Ducks | 23 | 02/20/2003 | Camanche | USA | Right | Right | 6' 2" | 195 lbs | - |
| Shaker, Mike | SS | Fredericksburg Nationals | 20 | 06/28/2005 | Sheldon | USA | Right | Right | 5' 9" | 160 lbs | - |
| Shearer, Jeremy | RP | Salem Red Sox | 20 | 01/23/2006 | Peachtree City | USA | Right | Right | 6' 0" | 175 lbs | - |
| Sheler, Jeremy | RF | Carolina Mudcats | 23 | 09/19/2002 | Concord | USA | Switch | Left | 6' 0" | 185 lbs | - |
| Sherwood, Pat | C | Myrtle Beach Pelicans | 23 | 04/19/2002 | Ronkonkoma | USA | Right | Right | 6' 0" | 205 lbs | - |
| Sierra, Daniel | RP | Down East Wood Ducks | 22 | 12/12/2003 | Temblador | VEN | Left | Left | 5' 9" | 170 lbs | - |
| Simmons, Steve | RP | Columbia Fireflies | 23 | 08/11/2002 | Hobart | USA | Left | Left | 6' 2" | 200 lbs | - |
| Skelton, Greg | RF | Down East Wood Ducks | 24 | 02/02/2002 | Catlin | USA | Left | Left | 6' 1" | 200 lbs | - |
| Smeltzer, Ronnie | RP | Fayetteville Woodpeckers | 20 | 02/19/2006 | West Haven | USA | Right | Right | 6' 1" | 180 lbs | - |
| Sparks, Travis | SP | Lynchburg Hillcats | 19 | 04/08/2006 | Santa Clarita | USA | Right | Right | 6' 2" | 190 lbs | - |
| Spicer, Dave | SS | Columbia Fireflies | 22 | 12/15/2003 | Pine Hills | USA | Right | Right | 6' 0" | 185 lbs | - |
| St. Dennis, Cody | CF | Kannapolis Cannon Ballers | 22 | 11/03/2003 | Clarion | USA | Right | Right | 6' 0" | 205 lbs | - |
| Suarez, Andy | SP | Salem Red Sox | 22 | 01/25/2004 | San Miguelito | PAN | Switch | Right | 6' 1" | 180 lbs | - |
| Suenaga, Yoshihito | 1B | Charleston RiverDogs | 21 | 08/30/2004 | Himeji | JPN | Left | Right | 6' 0" | 190 lbs | - |
| Suraci, John | SP | Carolina Mudcats | 23 | 01/12/2003 | Winston-Salem | USA | Right | Right | 6' 1" | 200 lbs | - |
| Sutton, Ed | SP | Charleston RiverDogs | 22 | 09/13/2003 | Glendale | USA | Left | Right | 6' 4" | 205 lbs | - |
| Sweet, Jesse | 2B | Fayetteville Woodpeckers | 21 | 03/23/2005 | University Park | USA | Right | Right | 6' 4" | 200 lbs | - |
