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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saathoff, Jason | C | Down East Wood Ducks | 21 | 05/18/2004 | Waterford Township | USA | Right | Right | 6' 1" | 215 lbs | - |
| Salas, Juan | 1B | Free Agent | 29 | 02/09/1996 | Maracaibo | VEN | Right | Right | 6' 0" | 210 lbs | - |
| Salazar, Edgar | 1B | Carolina Mudcats | 23 | 06/24/2002 | Oklahoma City | USA | Right | Right | 6' 4" | 220 lbs | - |
| Salazar, Gustavo | SP | Fredericksburg Nationals | 23 | 04/03/2002 | Jiguaní | CUB | Right | Left | 5' 11" | 185 lbs | - |
| Salazar, Pedro | C | Down East Wood Ducks | 23 | 04/12/2002 | Bajos de Haina | DOM | Left | Right | 6' 2" | 190 lbs | - |
| Sanchez, Carlos | SP | Myrtle Beach Pelicans | 20 | 09/19/2004 | Santo Domingo | DOM | Left | Left | 6' 2" | 190 lbs | - |
| Sanchez, Carlos | SP | Fredericksburg Nationals | 24 | 03/03/2001 | Sosúa | DOM | Right | Left | 6' 2" | 200 lbs | - |
| Sanchez, Ricky | RP | Salem Red Sox | 19 | 01/13/2006 | Santo Domingo | DOM | Right | Right | 6' 0" | 175 lbs | - |
| Sandoval, Willie | 1B | Columbia Fireflies | 20 | 09/05/2004 | Santo Domingo | DOM | Right | Right | 6' 1" | 195 lbs | - |
| Santana, Dennis | 3B | Carolina Mudcats | 23 | 03/09/2002 | Aloha | USA | Right | Right | 6' 0" | 195 lbs | - |
| Santiago, Jonathan | LF | Delmarva Shorebirds | 21 | 11/17/2003 | Arvada | USA | Left | Left | 6' 2" | 210 lbs | - |
| Santos, Victor | CL | Carolina Mudcats | 21 | 06/13/2004 | Luperón | DOM | Right | Right | 6' 3" | 195 lbs | - |
| Sawyer, Matt | SP | Salem Red Sox | 20 | 11/10/2004 | Dearborn | USA | Left | Left | 6' 1" | 190 lbs | - |
| Schomer, Kyle | SP | Kannapolis Cannon Ballers | 22 | 02/19/2003 | Los Angeles | USA | Right | Right | 5' 9" | 170 lbs | - |
| Schwanz, Lance | RP | Fredericksburg Nationals | 24 | 04/11/2001 | Bourg | USA | Right | Right | 5' 9" | 180 lbs | - |
| Schwerdtfeger, Jason | 3B | Kannapolis Cannon Ballers | 22 | 04/13/2003 | Downingtown | USA | Switch | Right | 6' 0" | 185 lbs | - |
| Shadrick, Glenn | RP | Down East Wood Ducks | 22 | 02/20/2003 | Camanche | USA | Right | Right | 6' 2" | 195 lbs | - |
| Shaker, Mike | 2B | Fredericksburg Nationals | 20 | 06/28/2005 | Sheldon | USA | Right | Right | 5' 9" | 160 lbs | - |
| Sheppard, Ron | LF | Columbia Fireflies | 23 | 10/11/2001 | Eustis | USA | Right | Right | 6' 3" | 220 lbs | - |
| Sidwell, Perry | SP | Fayetteville Woodpeckers | 23 | 03/10/2002 | Troy | USA | Right | Right | 6' 0" | 190 lbs | - |
| Sieczka, Ben | 2B | Charleston RiverDogs | 21 | 07/13/2004 | Upper Arlington | USA | Right | Right | 6' 0" | 180 lbs | - |
| Sierra, Daniel | RP | Down East Wood Ducks | 21 | 12/12/2003 | Temblador | VEN | Left | Left | 5' 9" | 170 lbs | - |
| Silvas, Mario | SP | Kannapolis Cannon Ballers | 21 | 09/17/2003 | Brooklyn | USA | Right | Right | 5' 11" | 180 lbs | - |
| Smeltzer, Ronnie | RP | Fayetteville Woodpeckers | 19 | 02/19/2006 | West Haven | USA | Right | Right | 6' 1" | 180 lbs | - |
| Smiley, Chris | SP | Free Agent | 27 | 11/01/1997 | Iselin | USA | Left | Left | 6' 4" | 215 lbs | - |
| Smith, Jamel | LF | Free Agent | 28 | 10/31/1996 | Chattanooga | USA | Left | Left | 6' 1" | 200 lbs | - |
| Smith, Jon | RF | Delmarva Shorebirds | 21 | 10/01/2003 | Brossard | CAN | Right | Right | 6' 0" | 205 lbs | - |
| Smith, Kasey | C | Fayetteville Woodpeckers | 23 | 01/03/2002 | Ridgefield Park | USA | Right | Right | 6' 0" | 200 lbs | - |
| Smith, Zack | SP | Charleston RiverDogs | 25 | 08/08/2000 | Elk Plain | USA | Left | Left | 5' 10" | 190 lbs | - |
| Soto, Miguel | CF | Columbia Fireflies | 22 | 11/06/2002 | Bajos de Haina | DOM | Right | Right | 6' 0" | 200 lbs | - |
| Sparks, Travis | SP | Lynchburg Hillcats | 19 | 04/08/2006 | Santa Clarita | USA | Right | Right | 6' 2" | 185 lbs | - |
| Stack, Brad | C | Columbia Fireflies | 23 | 07/29/2002 | Kansas City | USA | Switch | Right | 6' 0" | 215 lbs | - |
| Stevens, Casey | 2B | Kannapolis Cannon Ballers | 22 | 09/06/2002 | Friendship | USA | Right | Right | 6' 0" | 185 lbs | - |
| Suenaga, Yoshihito | CF | Charleston RiverDogs | 20 | 08/30/2004 | Himeji | JPN | Left | Right | 6' 0" | 190 lbs | - |
| Sypniewski, Mike | CL | Fredericksburg Nationals | 22 | 04/30/2003 | North Port | USA | Right | Right | 5' 10" | 175 lbs | - |
