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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saathoff, Jason | C | Round Rock Express | 21 | 05/18/2004 | Waterford Township | USA | Right | Right | 6' 1" | 215 lbs | - |
| Sanchez, Vicente | RP | El Paso Chihuahuas | 25 | 05/09/2000 | Mao | DOM | Right | Right | 6' 4" | 215 lbs | - |
| Sandoval, Ivan | CF | Free Agent | 28 | 09/03/1996 | Yaguate | DOM | Right | Right | 6' 0" | 185 lbs | - |
| Santorio, Gautier | RP | Reno Aces | 24 | 12/29/2000 | Canicattì | ITA | Left | Left | 5' 11" | 190 lbs | $3,000,000 |
| Sarmiento, Alex | 3B | Sugar Land Skeeters | 23 | 09/23/2001 | Santo Domingo | DOM | Right | Right | 5' 11" | 180 lbs | $1,200,000 |
| Sasaki, Sumiya | RP | Sacramento River Cats | 25 | 07/13/1999 | Okayama | JPN | Right | Right | 6' 3" | 215 lbs | - |
| Scott, Andre | 2B | Salt Lake Bees | 23 | 04/08/2002 | South Taft | USA | Right | Right | 6' 1" | 200 lbs | - |
| Segura, Juan | RP | Albuquerque Isotopes | 26 | 03/19/1999 | Esperanza | DOM | Right | Right | 6' 4" | 215 lbs | - |
| Settles, Bill | SP | Las Vegas Aviators | 26 | 05/04/1999 | Barstow | USA | Right | Right | 5' 10" | 190 lbs | - |
| Shaw, Brenden | RF | Las Vegas Aviators | 25 | 12/19/1999 | Landover Hills | USA | Left | Left | 5' 10" | 190 lbs | - |
| Slater, Toby | SS | Las Vegas Aviators | 24 | 04/05/2001 | Brisbane | AUS | Left | Right | 6' 0" | 185 lbs | - |
| Smallwood, Chris | RF | Tacoma Rainiers | 25 | 01/21/2000 | Ballwin | USA | Right | Right | 6' 1" | 210 lbs | $2,600,000 |
| Smith, Joey | 2B | Oklahoma City Dodgers | 25 | 08/19/1999 | Smithfield | USA | Right | Right | 6' 1" | 200 lbs | $2,000,000 |
| Smith, Matt | RP | Sugar Land Skeeters | 21 | 08/28/2003 | Exeter | USA | Right | Right | 6' 0" | 185 lbs | - |
| Solis, Luis | RP | Round Rock Express | 24 | 11/01/2000 | San Francisco de Macorís | DOM | Right | Right | 6' 4" | 215 lbs | - |
| Solorsano, Alex | 1B | Salt Lake Bees | 24 | 04/03/2001 | Maiquetía | VEN | Right | Left | 5' 10" | 180 lbs | - |
| Solorzano, Edgar | C | El Paso Chihuahuas | 23 | 10/24/2001 | Wichita | USA | Left | Right | 6' 3" | 225 lbs | $1,800,000 |
| Solt, Joey | RP | Free Agent | 19 | 09/06/2005 | Estes Park | USA | Switch | Right | 5' 11" | 170 lbs | - |
| Soto, Gus | SS | Sugar Land Skeeters | 21 | 12/12/2003 | South Beloit | USA | Right | Right | 6' 2" | 185 lbs | - |
| Sportsman, Aaron | RP | Round Rock Express | 24 | 09/28/2000 | Apache Junction | USA | Right | Right | 6' 1" | 195 lbs | $2,600,000 |
| Stack, Mike | CF | Las Vegas Aviators | 22 | 08/28/2002 | Upper Arlington | USA | Left | Left | 6' 1" | 190 lbs | - |
| Starnes, John | RP | Salt Lake Bees | 27 | 11/16/1997 | New York | USA | Right | Right | 6' 4" | 220 lbs | $740,000 |
| Stephens, Nick | RP | Albuquerque Isotopes | 34 | 04/02/1991 | Châteauguay | CAN | Switch | Left | 5' 10" | 190 lbs | - |
| Stewart, Jamar | LF | Albuquerque Isotopes | 26 | 04/25/1999 | Clarkstown | USA | Right | Right | 5' 10" | 190 lbs | $740,000 |
| Stout, Rich | RP | Sugar Land Skeeters | 21 | 05/31/2004 | Hampton Township | USA | Left | Right | 6' 4" | 200 lbs | - |
| Subasic, Aca | SS | Sacramento River Cats | 24 | 11/02/2000 | Suffolk | USA | Right | Right | 6' 2" | 195 lbs | $2,200,000 |
| Sunderman, Jay | CL | El Paso Chihuahuas | 29 | 02/22/1996 | Lompoc | USA | Right | Right | 6' 1" | 200 lbs | $1,500,000 |
| Sweet, Corey | C | Las Vegas Aviators | 23 | 01/31/2002 | New York | USA | Switch | Right | 6' 1" | 205 lbs | - |
