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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salazar, Pedro | C | Round Rock Express | 23 | 04/12/2002 | Bajos de Haina | DOM | Left | Right | 6' 2" | 190 lbs | - |
| Sanchez, Vicente | RP | El Paso Chihuahuas | 25 | 05/09/2000 | Mao | DOM | Right | Right | 6' 4" | 210 lbs | - |
| Santiago, Will | RP | El Paso Chihuahuas | 26 | 02/04/1999 | Miches | DOM | Right | Right | 6' 2" | 205 lbs | - |
| Sarmiento, Alex | 3B | Sugar Land Skeeters | 24 | 09/23/2001 | Santo Domingo | DOM | Right | Right | 5' 11" | 185 lbs | $1,900,000 |
| Sasaki, Sumiya | RP | Sacramento River Cats | 26 | 07/13/1999 | Okayama | JPN | Right | Right | 6' 3" | 215 lbs | - |
| Schultz, Steve | 1B | El Paso Chihuahuas | 24 | 10/02/2001 | Mesa | USA | Right | Left | 6' 1" | 195 lbs | - |
| Sebuggwawo, Salah | RP | Salt Lake Bees | 22 | 07/16/2003 | Dakar | SEN | Right | Right | 5' 9" | 165 lbs | - |
| Segura, Juan | RP | Albuquerque Isotopes | 26 | 03/19/1999 | Esperanza | DOM | Right | Right | 6' 4" | 215 lbs | - |
| Seligman, Bob | SP | Tacoma Rainiers | 24 | 05/01/2001 | Hernando | USA | Right | Right | 6' 2" | 205 lbs | - |
| Settles, Bill | RP | Las Vegas Aviators | 26 | 05/04/1999 | Barstow | USA | Right | Right | 5' 10" | 195 lbs | - |
| Sevilla, Dave | 2B | Tacoma Rainiers | 27 | 12/17/1997 | San Sebastian | PUR | Left | Right | 6' 0" | 200 lbs | - |
| Shaw, Brenden | RF | Las Vegas Aviators | 25 | 12/19/1999 | Landover Hills | USA | Left | Left | 5' 10" | 195 lbs | - |
| Sims, Brian | SP | Round Rock Express | 24 | 06/08/2001 | New York | USA | Right | Right | 6' 3" | 200 lbs | - |
| Slater, Toby | SS | Las Vegas Aviators | 24 | 04/05/2001 | Brisbane | AUS | Left | Right | 6' 0" | 190 lbs | - |
| Smith, Joe | 2B | Round Rock Express | 21 | 06/26/2004 | Geneva | USA | Right | Right | 6' 2" | 185 lbs | - |
| Solis, Luis | SP | Round Rock Express | 25 | 11/01/2000 | San Francisco de MacorÃs | DOM | Right | Right | 6' 4" | 215 lbs | - |
| Solorzano, Edgar | C | El Paso Chihuahuas | 24 | 10/24/2001 | Wichita | USA | Left | Right | 6' 3" | 230 lbs | $2,000,000 |
| Solt, Joey | RP | Free Agent | 20 | 09/06/2005 | Estes Park | USA | Switch | Right | 5' 11" | 170 lbs | - |
| Soto, Gus | SS | Sugar Land Skeeters | 21 | 12/12/2003 | South Beloit | USA | Right | Right | 6' 2" | 185 lbs | - |
| Spletter, Bill | C | Sugar Land Skeeters | 25 | 07/04/2000 | Dallas | USA | Right | Right | 6' 0" | 205 lbs | - |
| St. Amant, Victor | LF | Albuquerque Isotopes | 23 | 09/20/2002 | Lynnfield | USA | Left | Left | 6' 4" | 205 lbs | - |
| Stack, Mike | CF | Las Vegas Aviators | 23 | 08/28/2002 | Upper Arlington | USA | Left | Left | 6' 1" | 195 lbs | - |
| Starnes, John | RP | Free Agent | 28 | 11/16/1997 | New York | USA | Right | Right | 6' 4" | 215 lbs | - |
| Stout, Rich | SP | Sugar Land Skeeters | 21 | 05/31/2004 | Hampton Township | USA | Left | Right | 6' 4" | 200 lbs | - |
| Suarez, Jose | CF | Las Vegas Aviators | 24 | 10/08/2001 | San Cristóbal | DOM | Left | Right | 6' 1" | 195 lbs | - |
| Subasic, Aca | 1B | Free Agent | 25 | 11/02/2000 | Suffolk | USA | Right | Right | 6' 2" | 200 lbs | - |
| Sutherland, Gregg | SP | Round Rock Express | 22 | 08/05/2003 | Houston | USA | Left | Left | 5' 10" | 175 lbs | - |
| Swanson, Jim | SP | Sacramento River Cats | 21 | 12/01/2004 | Denver | USA | Switch | Right | 6' 2" | 190 lbs | - |
| Sweet, Corey | C | Las Vegas Aviators | 23 | 01/31/2002 | New York | USA | Switch | Right | 6' 1" | 205 lbs | - |
| Syner, Sam | RF | Free Agent | 27 | 10/04/1998 | Palmview | USA | Switch | Right | 6' 0" | 205 lbs | - |
