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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sanchez, Vicente | RP | El Paso Chihuahuas | 25 | 05/09/2000 | Mao | DOM | Right | Right | 6' 4" | 215 lbs | - |
| Sandoval, Ivan | CF | Free Agent | 28 | 09/03/1996 | Yaguate | DOM | Right | Right | 6' 0" | 185 lbs | - |
| Santorio, Gautier | RP | Reno Aces | 24 | 12/29/2000 | Canicattì | ITA | Left | Left | 5' 11" | 190 lbs | $3,000,000 |
| Sarmiento, Alex | 3B | Sugar Land Skeeters | 23 | 09/23/2001 | Santo Domingo | DOM | Right | Right | 5' 11" | 180 lbs | $1,200,000 |
| Sasaki, Masonori | SP | El Paso Chihuahuas | 22 | 07/03/2003 | Osaka | JPN | Left | Right | 6' 1" | 195 lbs | $740,000 |
| Sasaki, Sumiya | RP | Sacramento River Cats | 26 | 07/13/1999 | Okayama | JPN | Right | Right | 6' 3" | 215 lbs | - |
| Schildkraut, Cody | SP | Reno Aces | 25 | 02/05/2000 | Colton | USA | Right | Right | 6' 1" | 205 lbs | $2,800,000 |
| Schultz, Steve | 1B | El Paso Chihuahuas | 23 | 10/02/2001 | Mesa | USA | Right | Left | 6' 1" | 190 lbs | - |
| Scoggins, Josh | CF | Round Rock Express | 26 | 02/25/1999 | Natick | USA | Left | Right | 6' 1" | 205 lbs | $2,400,000 |
| Sebuggwawo, Salah | RP | Salt Lake Bees | 22 | 07/16/2003 | Dakar | SEN | Right | Right | 5' 9" | 165 lbs | - |
| Segura, Juan | RP | Albuquerque Isotopes | 26 | 03/19/1999 | Esperanza | DOM | Right | Right | 6' 4" | 215 lbs | - |
| Serna, Joel | RP | El Paso Chihuahuas | 24 | 01/11/2001 | Santo Domingo | DOM | Right | Right | 6' 3" | 200 lbs | $1,800,000 |
| Settles, Bill | SP | Las Vegas Aviators | 26 | 05/04/1999 | Barstow | USA | Right | Right | 5' 10" | 190 lbs | - |
| Shaw, Brenden | RF | Las Vegas Aviators | 25 | 12/19/1999 | Landover Hills | USA | Left | Left | 5' 10" | 195 lbs | - |
| Sims, Brian | RP | Round Rock Express | 24 | 06/08/2001 | New York | USA | Right | Right | 6' 3" | 205 lbs | - |
| Slater, Toby | SS | Las Vegas Aviators | 24 | 04/05/2001 | Brisbane | AUS | Left | Right | 6' 0" | 190 lbs | - |
| Smallwood, Chris | LF | Tacoma Rainiers | 25 | 01/21/2000 | Ballwin | USA | Right | Right | 6' 1" | 205 lbs | $2,600,000 |
| Solt, Joey | RP | Free Agent | 19 | 09/06/2005 | Estes Park | USA | Switch | Right | 5' 11" | 170 lbs | - |
| Sportsman, Aaron | SP | Round Rock Express | 24 | 09/28/2000 | Apache Junction | USA | Right | Right | 6' 1" | 195 lbs | $2,600,000 |
| St. Amant, Victor | LF | Albuquerque Isotopes | 22 | 09/20/2002 | Lynnfield | USA | Left | Left | 6' 4" | 205 lbs | - |
| Stack, Mike | CF | Las Vegas Aviators | 23 | 08/28/2002 | Upper Arlington | USA | Left | Left | 6' 1" | 190 lbs | - |
| Staiano, Josh | SP | Albuquerque Isotopes | 24 | 07/24/2001 | Lancaster | USA | Right | Right | 6' 0" | 205 lbs | $7,000,000 |
| Starnes, John | RP | Salt Lake Bees | 27 | 11/16/1997 | New York | USA | Right | Right | 6' 4" | 220 lbs | $740,000 |
| Suarez, Jose | CF | Las Vegas Aviators | 23 | 10/08/2001 | San Cristóbal | DOM | Left | Right | 6' 1" | 195 lbs | - |
| Subasic, Aca | 1B | Sacramento River Cats | 24 | 11/02/2000 | Suffolk | USA | Right | Right | 6' 2" | 200 lbs | $2,200,000 |
| Sunderman, Jay | CL | El Paso Chihuahuas | 29 | 02/22/1996 | Lompoc | USA | Right | Right | 6' 1" | 200 lbs | $1,500,000 |
| Swanson, Jim | SP | Sacramento River Cats | 20 | 12/01/2004 | Denver | USA | Switch | Right | 6' 2" | 190 lbs | - |
| Sweet, Corey | C | Las Vegas Aviators | 23 | 01/31/2002 | New York | USA | Switch | Right | 6' 1" | 205 lbs | - |
