| November 16, 2027 | NORTHERN ARIZONA LUMBERJACKS | W 88-70 | 1-0 | K. Brumm 17 | M. Lyall 6 | A. Barrios 6 |
| November 18, 2027 | UC-SAN DIEGO TRITONS Emerald Coast Classic | L 69-94 | 1-1 | A. Barrios 15 | M. Lyall 6 | K. Brumm 7 |
| November 23, 2027 | SE MISSOURI STATE REDHAWKS | W 77-67 | 2-1 | K. Brumm 16 | J. Holley 5 | K. Brumm 6 |
| November 26, 2027 | MISSOURI STATE BEARS | W 91-71 | 3-1 | M. Lyall 17 | M. Lyall 6 | B. Herring 8 |
| November 30, 2027 | MERRIMACK WARRIORS | L 71-78 | 3-2 | M. Lyall 22 | M. Lyall 4 | K. Brumm 15 |
| December 6, 2027 | MASSACHUSETTS MINUTEMEN | W 91-69 | 4-2 | M. Lyall 19 | M. Lyall 5 | K. Brumm 8 |
| December 13, 2027 | CINCINNATI BEARCATS | W 101-79 | 5-2 | M. Lyall 24 | M. Lyall 6 | J. Holley 5 |
| December 21, 2027 | WEBER STATE WILDCATS | W 86-61 | 6-2 | M. Lyall 26 | J. Holley 3 | J. Holley 9 |
| December 23, 2027 | ALBANY GREAT DANES | W 92-75 | 7-2 | J. Holley 18 | M. Lyall 6 | J. Holley 7 |
| December 26, 2027 | @ Seton Hall Pirates* | L 75-77 | 7-3 | P. McNeil 21 | M. Lyall 3 | J. Holley 7 |
| December 30, 2027 | PROVIDENCE FRIARS* | L 74-88 | 7-4 | P. McNeil 21 | M. Lyall 7 | K. Brumm 8 |
| January 2, 2028 | @ #16 Creighton Blue Jays* | L 77-98 | 7-5 | M. Lyall 26 | J. Holley 5 | A. Barrios 6 |
| January 4, 2028 | GEORGETOWN HOYAS* | L 87-101 | 7-6 | K. Brumm 20 | M. Lyall 3 | J. Holley 9 |
| January 11, 2028 | @ Butler Bulldogs* | L 70-74 | 7-7 | M. Lyall 23 | M. Lyall 3 | P. McNeil 7 |
| January 13, 2028 | @ Villanova Wildcats* | L 73-80 | 7-8 | P. McNeil 25 | M. Lynch 5 | P. McNeil 4 |
| January 20, 2028 | DEPAUL BLUE DEMONS* | W 87-54 | 8-8 | A. Barrios 23 | M. Lynch 5 | A. Barrios 10 |
| January 23, 2028 | #11 CONNECTICUT HUSKIES* | L 72-82 | 8-9 | A. Barrios 16 | M. Lyall 7 | K. Brumm 7 |
| January 27, 2028 | @ St. Johns Red Storm* | W 85-76 | 9-9 | A. Winston 18 | M. Lynch 8 | J. Marshall 7 |
| January 30, 2028 | @ Marquette Golden Eagles* | L 73-82 | 9-10 | M. Lyall 16 | M. Lyall 3 | A. Barrios 7 |
| February 1, 2028 | @ Georgetown Hoyas* | L 85-103 | 9-11 | M. Lyall 11 | A. Barrios 3 | K. Brumm 4 |
| February 3, 2028 | VILLANOVA WILDCATS* | W 66-54 | 10-11 | J. Holley 18 | M. Lyall 5 | K. Brumm 9 |
| February 8, 2028 | BUTLER BULLDOGS* | W 74-55 | 11-11 | M. Lyall 17 | J. Holley 3 | P. McNeil 6 |
| February 10, 2028 | @ Providence Friars* | L 82-96 | 11-12 | K. Brumm 15 | M. Lyall 4 | K. Brumm 7 |
| February 15, 2028 | ST. JOHNS RED STORM* | W 83-70 | 12-12 | M. Lyall 28 | J. Holley 5 | P. McNeil 8 |
| February 17, 2028 | #22 MARQUETTE GOLDEN EAGLES* | L 65-72 | 12-13 | P. McNeil 16 | M. Lyall 5 | K. Brumm 6 |
| February 22, 2028 | @ DePaul Blue Demons* | L 63-91 | 12-14 | M. Lyall 12 | M. Lynch 6 | K. Brumm 7 |
| February 24, 2028 | @ #9 Connecticut Huskies* | L 75-92 | 12-15 | M. Lyall 15 | B. Herring 3 | B. Herring 9 |
| March 1, 2028 | SETON HALL PIRATES* | W 65-64 | 13-15 | M. Lyall 19 | P. McNeil 4 | P. McNeil 6 |
| March 3, 2028 | #14 CREIGHTON BLUE JAYS* | L 69-91 | 13-16 | A. Barrios 12 | M. Lyall 4 | A. Barrios 7 |
| March 9, 2028 | @ DePaul Blue Demons (9-20, 8-9 Home) Big East Tournament | - | | | | |
