| November 15, 2027 | OKLAHOMA SOONERS | L 67-71 | 0-1 | J. James 19 | J. James 7 | T. Jefferson 7 |
| November 18, 2027 | @ Minnesota Golden Gophers | L 83-90 | 0-2 | J. James 21 | J. James 6 | T. Jefferson 8 |
| November 22, 2027 | RIDER BRONCS | W 69-50 | 1-2 | M. Neeser 23 | M. Neeser 3 | T. Jefferson 13 |
| November 29, 2027 | @ Arizona State Sun Devils | W 81-72 | 2-2 | E. Roland 19 | M. Satchell 4 | B. Williams 9 |
| December 2, 2027 | @ Northwestern Wildcats | W 73-46 | 3-2 | J. James 28 | M. Neeser 7 | T. Jefferson 11 |
| December 6, 2027 | FURMAN PALADINS | W 66-49 | 4-2 | J. Poge 14 | J. James 5 | B. Williams 9 |
| December 13, 2027 | #14 CINCINNATI BEARCATS | L 66-76 | 4-3 | M. Satchell 17 | J. James 9 | M. Satchell 8 |
| December 16, 2027 | CHARLOTTE 49ERS Battle 4 Atlantis | W 67-59 | 5-3 | J. James 21 | J. James 5 | T. Jefferson 13 |
| December 17, 2027 | @ Wisconsin Badgers Battle 4 Atlantis | L 74-83 | 5-4 | J. James 19 | J. James 8 | J. James 5 |
| December 20, 2027 | SAN JOSE STATE SPARTANS | L 65-67 | 5-5 | J. James 18 | E. Roland 3 | J. James 8 |
| December 26, 2027 | @ #16 Creighton Blue Jays* | L 65-78 | 5-6 | J. James 16 | J. James 5 | B. Williams 9 |
| December 28, 2027 | #21 VILLANOVA WILDCATS* | L 61-81 | 5-7 | M. Neeser 12 | B. Williams 3 | B. Williams 7 |
| December 30, 2027 | ST. JOHNS RED STORM* | W 76-57 | 6-7 | B. Williams 19 | J. James 5 | T. Jefferson 7 |
| January 4, 2028 | @ #2 Marquette Golden Eagles* | L 69-86 | 6-8 | J. James 15 | M. Neeser 4 | J. James 7 |
| January 11, 2028 | DEPAUL BLUE DEMONS* | W 77-66 | 7-8 | J. James 21 | J. James 5 | M. Neeser 8 |
| January 13, 2028 | GEORGETOWN HOYAS* | W 65-61 | 8-8 | J. James 22 | J. James 3 | T. Jefferson 10 |
| January 20, 2028 | @ Seton Hall Pirates* | L 64-75 | 8-9 | J. James 12 | M. Neeser 6 | T. Jefferson 9 |
| January 23, 2028 | @ Providence Friars* | L 59-71 | 8-10 | J. James 14 | M. Neeser 2 | J. James 9 |
| January 25, 2028 | #23 BUTLER BULLDOGS* | W 75-60 | 9-10 | J. James 15 | J. James 7 | M. Neeser 5 |
| January 27, 2028 | #1 MARQUETTE GOLDEN EAGLES* | L 61-80 | 9-11 | J. James 19 | M. Neeser 6 | T. Jefferson 8 |
| February 1, 2028 | CONNECTICUT HUSKIES* | L 56-59 | 9-12 | M. Neeser 14 | J. James 6 | M. Neeser 8 |
| February 3, 2028 | #20 CREIGHTON BLUE JAYS* | W 79-66 | 10-12 | J. James 18 | J. James 7 | B. Williams 10 |
| February 8, 2028 | @ Georgetown Hoyas* | L 67-85 | 10-13 | J. James 18 | M. Neeser 5 | B. Williams 8 |
| February 10, 2028 | @ DePaul Blue Demons* | L 90-92 OT | 10-14 | M. Neeser 22 | J. James 6 | B. Williams 13 |
| February 15, 2028 | @ Connecticut Huskies* | W 72-64 | 11-14 | J. James 19 | J. James 5 | T. Jefferson 10 |
| February 17, 2028 | @ #23 Butler Bulldogs* | L 54-69 | 11-15 | M. Neeser 13 | J. James 8 | B. Williams 9 |
| February 22, 2028 | SETON HALL PIRATES* | L 69-78 | 11-16 | J. James 20 | M. Neeser 6 | B. Williams 9 |
| February 24, 2028 | PROVIDENCE FRIARS* | W 68-48 | 12-16 | J. James 22 | M. Neeser 4 | B. Williams 12 |
| March 1, 2028 | @ St. Johns Red Storm* | L 61-72 | 12-17 | J. James 13 | J. James 4 | T. Jefferson 11 |
| March 3, 2028 | @ Villanova Wildcats* | L 65-85 | 12-18 | J. James 15 | J. James 7 | J. James 8 |
| March 9, 2028 | @ Villanova Wildcats Big East Tournament | W 76-53 | 13-18 | M. Neeser 25 | J. James 5 | B. Williams 7 |
| March 10, 2028 | @ Butler Bulldogs Big East Tournament | W 75-64 OT | 14-18 | M. Neeser 15 | M. Neeser 5 | B. Williams 10 |
| March 11, 2028 | PROVIDENCE FRIARS Big East Tournament | L 58-69 | 14-19 | J. James 18 | M. Neeser 4 | J. James 8 |
