| November 15, 2027 | OKLAHOMA SOONERS | L 67-71 | 0-1 | J. James 19 | J. James 7 | T. Jefferson 7 |
| November 18, 2027 | @ Minnesota Golden Gophers | L 83-90 | 0-2 | J. James 21 | J. James 6 | T. Jefferson 8 |
| November 22, 2027 | RIDER BRONCS | W 69-50 | 1-2 | M. Neeser 23 | M. Neeser 3 | T. Jefferson 13 |
| November 29, 2027 | @ Arizona State Sun Devils | W 81-72 | 2-2 | E. Roland 19 | M. Satchell 4 | B. Williams 9 |
| December 2, 2027 | @ Northwestern Wildcats | W 73-46 | 3-2 | J. James 28 | M. Neeser 7 | T. Jefferson 11 |
| December 6, 2027 | FURMAN PALADINS | W 66-49 | 4-2 | J. Poge 14 | J. James 5 | B. Williams 9 |
| December 13, 2027 | #14 CINCINNATI BEARCATS | L 66-76 | 4-3 | M. Satchell 17 | J. James 9 | M. Satchell 8 |
| December 16, 2027 | CHARLOTTE 49ERS Battle 4 Atlantis | W 67-59 | 5-3 | J. James 21 | J. James 5 | T. Jefferson 13 |
| December 17, 2027 | @ Wisconsin Badgers Battle 4 Atlantis | L 74-83 | 5-4 | J. James 19 | J. James 8 | J. James 5 |
| December 20, 2027 | SAN JOSE STATE SPARTANS (1-9, 0-5 Away) | - | | | | |
| December 26, 2027 | @ Creighton Blue Jays (8-2, 0-0, 6-1 Home)* | - | | | | |
| December 28, 2027 | VILLANOVA WILDCATS (7-0, 0-0, 3-0 Away)* | - | | | | |
| December 30, 2027 | ST. JOHNS RED STORM (4-4, 0-0, 1-1 Away)* | - | | | | |
| January 4, 2028 | @ Marquette Golden Eagles (10-1, 0-0, 5-1 Home)* | - | | | | |
| January 11, 2028 | DEPAUL BLUE DEMONS (6-2, 0-0, 1-2 Away)* | - | | | | |
| January 13, 2028 | GEORGETOWN HOYAS (8-0, 0-0, 1-0 Away)* | - | | | | |
| January 20, 2028 | @ Seton Hall Pirates (9-1, 0-0, 5-1 Home)* | - | | | | |
| January 23, 2028 | @ Providence Friars (7-3, 0-0, 3-3 Home)* | - | | | | |
| January 25, 2028 | BUTLER BULLDOGS (6-4, 0-0, 1-3 Away)* | - | | | | |
| January 27, 2028 | MARQUETTE GOLDEN EAGLES (10-1, 0-0, 1-0 Away)* | - | | | | |
| February 1, 2028 | CONNECTICUT HUSKIES (2-6, 0-0, 0-1 Away)* | - | | | | |
| February 3, 2028 | CREIGHTON BLUE JAYS (8-2, 0-0, 0-0 Away)* | - | | | | |
| February 8, 2028 | @ Georgetown Hoyas (8-0, 0-0, 7-0 Home)* | - | | | | |
| February 10, 2028 | @ DePaul Blue Demons (6-2, 0-0, 5-0 Home)* | - | | | | |
| February 15, 2028 | @ Connecticut Huskies (2-6, 0-0, 1-4 Home)* | - | | | | |
| February 17, 2028 | @ Butler Bulldogs (6-4, 0-0, 2-1 Home)* | - | | | | |
| February 22, 2028 | SETON HALL PIRATES (9-1, 0-0, 1-0 Away)* | - | | | | |
| February 24, 2028 | PROVIDENCE FRIARS (7-3, 0-0, 1-0 Away)* | - | | | | |
| March 1, 2028 | @ St. Johns Red Storm (4-4, 0-0, 3-2 Home)* | - | | | | |
| March 3, 2028 | @ Villanova Wildcats (7-0, 0-0, 4-0 Home)* | - | | | | |
