| November 15, 2027 | BELMONT BRUINS | W 80-59 | 1-0 | L. Evans 16 | L. Evans 3 | E. Taylor 8 |
| November 18, 2027 | SOUTHERN MISSISSIPPI GOLDEN EAGLES | W 83-72 | 2-0 | E. Taylor 16 | L. Evans 5 | M. Battier 8 |
| November 22, 2027 | @ #1 Kansas Jayhawks | L 58-77 | 2-1 | E. Taylor 15 | L. Evans 6 | B. Jenkins 7 |
| November 29, 2027 | PEPPERDINE WAVES | W 73-64 | 3-1 | M. Stapleton 14 | M. Cherry 7 | E. Taylor 8 |
| December 6, 2027 | YALE BULLDOGS | L 55-75 | 3-2 | L. Evans 15 | L. Evans 5 | E. Taylor 7 |
| December 13, 2027 | @ #1 Marquette Golden Eagles | W 70-57 | 4-2 | E. Taylor 19 | L. Evans 8 | E. Taylor 11 |
| December 16, 2027 | UC-SANTA BARBARA GAUCHOS Battle 4 Atlantis | W 89-72 | 5-2 | L. Evans 19 | L. Evans 7 | L. Evans 8 |
| December 17, 2027 | XAVIER MUSKETEERS Battle 4 Atlantis | W 83-74 | 6-2 | E. Taylor 21 | L. Evans 6 | B. Jenkins 7 |
| December 18, 2027 | @ #17 Louisville Cardinals Battle 4 Atlantis | W 85-75 | 7-2 | L. Evans 19 | L. Evans 6 | M. Battier 12 |
| December 20, 2027 | TOLEDO ROCKETS | W 71-56 | 8-2 | E. Taylor 32 | L. Evans 3 | E. Taylor 9 |
| December 22, 2027 | SOUTHERN UTAH THUNDERBIRDS | W 69-62 | 9-2 | E. Taylor 27 | B. Jenkins 5 | E. Taylor 14 |
| December 26, 2027 | @ Washington Huskies* | L 60-75 | 9-3 | M. Battier 14 | B. Jenkins 4 | M. Battier 7 |
| December 28, 2027 | OHIO STATE BUCKEYES* | W 80-68 | 10-3 | L. Evans 16 | L. Evans 5 | M. Battier 11 |
| January 2, 2028 | MINNESOTA GOLDEN GOPHERS* | W 79-57 | 11-3 | E. Taylor 29 | B. Jenkins 2 | E. Taylor 10 |
| January 4, 2028 | @ Northwestern Wildcats* | L 67-74 | 11-4 | B. Jenkins 18 | M. Stapleton 5 | E. Taylor 7 |
| January 9, 2028 | @ Oregon Ducks* | W 88-63 | 12-4 | L. Evans 28 | L. Evans 7 | M. Battier 12 |
| January 11, 2028 | @ UCLA Bruins* | L 70-82 | 12-5 | B. Jenkins 17 | L. Evans 5 | E. Taylor 7 |
| January 16, 2028 | #2 MICHIGAN WOLVERINES* | L 59-84 | 12-6 | L. Evans 19 | M. Cherry 6 | M. Battier 10 |
| January 18, 2028 | @ Purdue Boilermakers* | L 75-78 | 12-7 | B. Jenkins 18 | L. Evans 7 | M. Battier 9 |
| January 23, 2028 | PENN STATE NITTANY LIONS* | W 82-79 | 13-7 | E. Taylor 22 | L. Evans 3 | E. Taylor 11 |
| January 25, 2028 | NEBRASKA CORNHUSKERS* | W 86-62 | 14-7 | E. Taylor 24 | M. Cherry 4 | M. Battier 9 |
| January 30, 2028 | @ #25 Michigan State Spartans* | L 77-80 OT | 14-8 | E. Taylor 21 | B. Jenkins 5 | E. Taylor 8 |
| February 1, 2028 | #11 MARYLAND TERRAPINS* | W 95-87 | 15-8 | L. Evans 19 | L. Evans 3 | M. Battier 7 |
| February 6, 2028 | RUTGERS SCARLET KNIGHTS* | W 78-63 | 16-8 | E. Taylor 23 | L. Evans 8 | E. Taylor 10 |
| February 8, 2028 | ILLINOIS FIGHTING ILLINI* | W 75-56 | 17-8 | L. Evans 17 | L. Evans 5 | E. Taylor 11 |
| February 13, 2028 | @ Iowa Hawkeyes* | L 73-85 | 17-9 | L. Evans 16 | L. Evans 2 | M. Battier 6 |
| February 15, 2028 | SOUTHERN CALIFORNIA TROJANS* | W 73-64 | 18-9 | E. Taylor 21 | L. Evans 5 | E. Taylor 15 |
| February 20, 2028 | @ Indiana Hoosiers* | W 91-81 OT | 19-9 | M. Battier 25 | P. Gray 5 | M. Battier 8 |
| February 22, 2028 | @ Illinois Fighting Illini* | W 59-48 | 20-9 | L. Evans 15 | B. Jenkins 3 | M. Battier 11 |
| February 27, 2028 | @ Nebraska Cornhuskers* | L 75-83 | 20-10 | L. Evans 16 | L. Evans 4 | E. Taylor 10 |
| March 1, 2028 | IOWA HAWKEYES* | W 73-62 | 21-10 | L. Evans 18 | E. Taylor 4 | M. Battier 12 |
| March 9, 2028 | IOWA HAWKEYES Big 10 Tournament | W 84-62 | 22-10 | E. Taylor 24 | L. Evans 7 | E. Taylor 10 |
| March 10, 2028 | @ #11 Maryland Terrapins Big 10 Tournament | L 64-78 | 22-11 | E. Taylor 20 | B. Jenkins 3 | E. Taylor 10 |
