| November 18, 2027 | LOUISIANA TECH BULLDOGS Sunshine Slam | W 88-72 | 1-0 | W. Wood 22 | J. Persinger 5 | T. West 11 |
| November 19, 2027 | @ Notre Dame Fighting Irish Sunshine Slam | L 65-85 | 1-1 | T. West 19 | L. Hancock 3 | D. Layton 7 |
| November 21, 2027 | STETSON HATTERS | W 79-60 | 2-1 | T. West 29 | L. Hancock 8 | T. West 10 |
| November 25, 2027 | @ Saint Louis Billikens | L 77-93 | 2-2 | D. Layton 16 | L. Hancock 9 | J. Persinger 8 |
| November 28, 2027 | SACRAMENTO STATE HORNETS | W 90-69 | 3-2 | T. West 17 | L. Hancock 6 | C. Griffin 8 |
| December 1, 2027 | TEXAS-EL PASO MINERS | W 78-66 | 4-2 | C. Griffin 14 | L. Hancock 4 | T. West 11 |
| December 5, 2027 | @ #2 Kansas Jayhawks | L 51-65 | 4-3 | C. Griffin 12 | L. Hancock 11 | T. West 7 |
| December 9, 2027 | OAKLAND GOLDEN GRIZZLIES | W 79-57 | 5-3 | T. West 19 | C. Griffin 4 | L. Hancock 9 |
| December 12, 2027 | EASTERN WASHINGTON EAGLES | L 68-87 | 5-4 | T. West 18 | L. Hancock 3 | D. Layton 7 |
| December 20, 2027 | @ Oklahoma Sooners | L 65-79 | 5-5 | J. Persinger 17 | C. Griffin 5 | T. West 12 |
| December 26, 2027 | INDIANA HOOSIERS* | W 73-66 | 6-5 | W. Wood 19 | L. Hancock 9 | D. Layton 8 |
| December 28, 2027 | MINNESOTA GOLDEN GOPHERS* | W 89-73 | 7-5 | T. West 19 | L. Hancock 8 | D. Layton 7 |
| January 2, 2028 | #23 MICHIGAN WOLVERINES* | L 68-83 | 7-6 | T. West 16 | L. Hancock 12 | D. Layton 10 |
| January 4, 2028 | @ Nebraska Cornhuskers* | L 88-97 | 7-7 | L. Hancock 17 | L. Hancock 3 | C. Griffin 6 |
| January 9, 2028 | IOWA HAWKEYES* | L 76-90 | 7-8 | T. West 17 | L. Hancock 8 | T. West 8 |
| January 11, 2028 | PENN STATE NITTANY LIONS* | L 79-86 | 7-9 | L. Hancock 26 | L. Hancock 5 | T. West 9 |
| January 16, 2028 | @ Southern California Trojans* | W 76-69 | 8-9 | T. West 16 | L. Hancock 3 | T. West 21 |
| January 18, 2028 | NORTHWESTERN WILDCATS* | L 76-79 | 8-10 | D. Layton 16 | L. Hancock 12 | J. Persinger 4 |
| January 23, 2028 | @ UCLA Bruins* | L 79-90 | 8-11 | T. West 16 | L. Hancock 7 | T. West 8 |
| January 25, 2028 | #15 OREGON DUCKS* | W 91-72 | 9-11 | T. West 22 | L. Hancock 5 | T. West 12 |
| January 30, 2028 | #2 MICHIGAN STATE SPARTANS* | L 74-105 | 9-12 | L. Hancock 17 | L. Hancock 6 | D. Layton 10 |
| February 1, 2028 | @ Illinois Fighting Illini* | L 84-93 | 9-13 | C. Griffin 20 | L. Hancock 5 | J. Persinger 8 |
| February 6, 2028 | @ #4 Wisconsin Badgers* | L 78-103 | 9-14 | C. Griffin 15 | L. Hancock 6 | D. Layton 8 |
| February 8, 2028 | @ Rutgers Scarlet Knights* | W 92-74 | 10-14 | J. Persinger 17 | L. Hancock 8 | D. Layton 8 |
| February 13, 2028 | @ Ohio State Buckeyes* | W 85-80 | 11-14 | J. Persinger 19 | L. Hancock 8 | C. Griffin 6 |
| February 15, 2028 | @ #14 Purdue Boilermakers* | L 56-79 | 11-15 | C. Griffin 14 | L. Hancock 5 | L. Hancock 7 |
| February 20, 2028 | MARYLAND TERRAPINS* | W 78-77 OT | 12-15 | T. West 20 | L. Hancock 5 | D. Layton 10 |
| February 22, 2028 | #14 PURDUE BOILERMAKERS* | L 55-66 | 12-16 | C. Griffin 12 | L. Hancock 2 | T. West 13 |
| February 27, 2028 | @ Oregon Ducks* | L 61-78 | 12-17 | T. West 13 | L. Hancock 8 | L. Hancock 7 |
| March 1, 2028 | @ Maryland Terrapins* | L 64-76 | 12-18 | J. Persinger 13 | L. Hancock 5 | T. West 6 |
