| November 14, 2027 | HARVARD CRIMSON NIT Preseason Tip Off | W 80-65 | 1-0 | M. Smiley 22 | M. Smiley 4 | M. Richerson 7 |
| November 16, 2027 | #8 LOUISVILLE CARDINALS NIT Preseason Tip Off | L 67-76 | 1-1 | M. Richerson 17 | J. Mannion 6 | T. Wortman 12 |
| November 22, 2027 | @ George Mason Patriots | W 69-68 | 2-1 | M. Richerson 19 | J. Mannion 8 | M. Smiley 7 |
| November 26, 2027 | SAN DIEGO STATE AZTECS | L 72-81 | 2-2 | T. Wortman 18 | J. Mannion 3 | M. Richerson 7 |
| November 30, 2027 | TROY TROJANS | W 70-62 | 3-2 | M. Smiley 18 | M. Smiley 5 | M. Richerson 9 |
| December 3, 2027 | APPALACHIAN STATE MOUNTAINEERS | W 74-59 | 4-2 | M. Smiley 20 | J. Mannion 7 | M. Richerson 10 |
| December 7, 2027 | ABILENE CHRISTIAN WILDCATS | W 88-64 | 5-2 | M. Smiley 19 | J. Mannion 7 | T. Wortman 13 |
| December 13, 2027 | @ Saint Josephs Hawks | W 80-70 | 6-2 | J. Mannion 14 | M. Smiley 3 | M. Richerson 8 |
| December 16, 2027 | DAYTON FLYERS | W 86-67 | 7-2 | M. Smiley 24 | J. Mannion 6 | M. Richerson 8 |
| December 21, 2027 | LIBERTY FLAMES | W 65-50 | 8-2 | M. Richerson 17 | M. Person 4 | T. Wortman 10 |
| December 26, 2027 | #23 MARQUETTE GOLDEN EAGLES* | L 66-70 | 8-3 | M. Smiley 17 | M. Richerson 5 | T. Wortman 10 |
| December 28, 2027 | @ #10 Connecticut Huskies* | L 68-86 | 8-4 | M. Richerson 17 | J. Mannion 5 | M. Richerson 9 |
| December 30, 2027 | @ DePaul Blue Demons* | L 60-61 | 8-5 | M. Richerson 12 | J. Mannion 3 | T. Wortman 11 |
| January 2, 2028 | ST. JOHNS RED STORM* | W 71-46 | 9-5 | M. Smiley 29 | J. Mannion 5 | M. Richerson 9 |
| January 4, 2028 | @ Butler Bulldogs* | W 73-55 | 10-5 | J. Mannion 12 | M. Smiley 3 | M. Smiley 5 |
| January 6, 2028 | PROVIDENCE FRIARS* | W 83-63 | 11-5 | M. Smiley 28 | T. Wortman 7 | M. Richerson 7 |
| January 13, 2028 | XAVIER MUSKETEERS* | W 80-73 | 12-5 | T. Wortman 17 | J. Mannion 5 | M. Richerson 8 |
| January 18, 2028 | @ #12 Creighton Blue Jays* | L 52-71 | 12-6 | J. Mannion 18 | J. Mannion 3 | T. Wortman 8 |
| January 20, 2028 | @ Seton Hall Pirates* | W 55-47 | 13-6 | M. Smiley 19 | M. Richerson 3 | M. Richerson 10 |
| January 27, 2028 | GEORGETOWN HOYAS* | W 93-80 | 14-6 | M. Smiley 22 | J. Mannion 11 | M. Richerson 8 |
| February 1, 2028 | BUTLER BULLDOGS* | W 65-47 | 15-6 | M. Smiley 22 | J. Mannion 5 | M. Richerson 6 |
| February 3, 2028 | @ Xavier Musketeers* | L 54-66 | 15-7 | J. Mannion 17 | J. Mannion 4 | M. Richerson 11 |
| February 8, 2028 | SETON HALL PIRATES* | W 67-64 | 16-7 | A. Allen 12 | A. Allen 5 | J. Underwood 7 |
| February 10, 2028 | #13 CREIGHTON BLUE JAYS* | L 64-66 | 16-8 | T. Wortman 16 | J. Mannion 6 | T. Wortman 7 |
| February 15, 2028 | @ Providence Friars* | L 55-74 | 16-9 | M. Smiley 16 | J. Mannion 7 | M. Richerson 5 |
| February 17, 2028 | @ Georgetown Hoyas* | L 58-80 | 16-10 | T. Wortman 17 | J. Mannion 4 | M. Richerson 11 |
| February 22, 2028 | @ St. Johns Red Storm* | L 79-87 OT | 16-11 | M. Richerson 23 | M. Person 6 | T. Wortman 12 |
| February 24, 2028 | @ #21 Marquette Golden Eagles* | L 65-76 | 16-12 | M. Smiley 16 | J. Mannion 4 | M. Richerson 8 |
| March 1, 2028 | DEPAUL BLUE DEMONS* | W 89-80 | 17-12 | T. Wortman 20 | J. Mannion 6 | M. Richerson 13 |
| March 3, 2028 | #9 CONNECTICUT HUSKIES* | L 63-89 | 17-13 | J. Mannion 15 | J. Mannion 3 | T. Wortman 6 |
| March 9, 2028 | BUTLER BULLDOGS (12-18, 0-10 Away) Big East Tournament | - | | | | |
