| November 16, 2025 | @ Indiana Hoosiers | W 92-81 | 1-0 | J. Brown 18 | J. Brown 4 | W. Sykes 10 |
| November 19, 2025 | WESTERN KENTUCKY HILLTOPPERS | W 67-63 | 2-0 | J. Brown 27 | K. Avery 6 | J. Vaughn 7 |
| November 21, 2025 | TEXAS A&M-CC ISLANDERS Charleston Classic | L 63-74 | 2-1 | J. Vaughn 16 | K. Avery 5 | J. Vaughn 7 |
| November 30, 2025 | DEPAUL BLUE DEMONS | W 110-102 OT | 3-1 | J. Brown 30 | B. Trilli 6 | W. Sykes 9 |
| December 3, 2025 | MONTANA GRIZZLIES | L 56-67 | 3-2 | W. Sykes 19 | K. Avery 3 | J. Vaughn 10 |
| December 7, 2025 | SAINT JOSEPHS HAWKS | W 90-83 OT | 4-2 | J. Brown 27 | K. Avery 6 | W. Sykes 14 |
| December 10, 2025 | @ #17 Texas A&M Aggies | L 69-88 | 4-3 | D. Mobley 12 | K. Avery 3 | D. Mobley 9 |
| December 14, 2025 | NORTH TEXAS MEAN GREEN | L 60-75 | 4-4 | J. Brown 21 | K. Avery 6 | J. Vaughn 8 |
| December 21, 2025 | PORTLAND STATE VIKINGS | W 87-53 | 5-4 | M. Edwards 15 | K. Avery 4 | W. Sykes 11 |
| December 26, 2025 | CLEMSON TIGERS* | L 71-77 | 5-5 | J. Brown 22 | K. Avery 4 | W. Sykes 11 |
| December 28, 2025 | @ Virginia Tech Hokies* | L 76-90 | 5-6 | K. Avery 18 | K. Avery 5 | J. Vaughn 11 |
| January 2, 2026 | #17 PITTSBURGH PANTHERS* | W 63-60 | 6-6 | J. Brown 14 | K. Avery 5 | D. Mobley 10 |
| January 4, 2026 | @ #1 North Carolina Tar Heels* | L 59-79 | 6-7 | J. Vaughn 16 | J. Cummings 3 | J. Vaughn 11 |
| January 9, 2026 | STANFORD CARDINAL* | W 84-75 | 7-7 | J. Brown 28 | K. Avery 4 | W. Sykes 6 |
| January 11, 2026 | @ Florida State Seminoles* | L 67-74 | 7-8 | K. Avery 23 | D. Mobley 3 | W. Sykes 11 |
| January 16, 2026 | #2 DUKE BLUE DEVILS* | W 96-83 | 8-8 | J. Vaughn 17 | J. Vaughn 5 | D. Mobley 10 |
| January 18, 2026 | @ NC-State Wolfpack* | L 52-74 | 8-9 | W. Sykes 14 | W. Sykes 3 | W. Sykes 10 |
| January 23, 2026 | @ Notre Dame Fighting Irish* | W 71-67 | 9-9 | J. Vaughn 21 | D. Mobley 4 | D. Mobley 9 |
| January 25, 2026 | @ Boston College Eagles* | L 75-80 | 9-10 | W. Sykes 27 | J. Brown 4 | J. Vaughn 12 |
| January 30, 2026 | @ Syracuse Orange* | L 104-113 OT | 9-11 | K. Avery 22 | K. Avery 11 | J. Vaughn 8 |
| February 1, 2026 | #14 LOUISVILLE CARDINALS* | W 77-64 | 10-11 | W. Sykes 22 | K. Avery 6 | J. Vaughn 11 |
| February 6, 2026 | WAKE FOREST DEMON DEACONS* | L 71-74 | 10-12 | J. Vaughn 21 | K. Avery 4 | W. Sykes 11 |
| February 8, 2026 | GEORGIA TECH YELLOW JACKETS* | W 88-61 | 11-12 | J. Brown 18 | J. Brown 4 | J. Vaughn 11 |
| February 13, 2026 | CALIFORNIA GOLDEN BEARS* | L 59-70 | 11-13 | J. Brown 19 | K. Avery 5 | J. Brown 7 |
| February 15, 2026 | @ Miami (FL) Hurricanes* | L 63-71 | 11-14 | K. Avery 18 | J. Vaughn 5 | W. Sykes 8 |
| February 20, 2026 | @ Southern Methodist Mustangs* | L 76-80 | 11-15 | K. Avery 23 | J. Brown 4 | J. Vaughn 10 |
| February 22, 2026 | @ Georgia Tech Yellow Jackets* | L 85-88 | 11-16 | K. Avery 17 | J. Vaughn 4 | W. Sykes 12 |
| February 27, 2026 | BOSTON COLLEGE EAGLES* | W 74-64 | 12-16 | J. Brown 18 | K. Avery 8 | J. Vaughn 7 |
| March 1, 2026 | MIAMI (FL) HURRICANES* | L 74-85 | 12-17 | J. Vaughn 17 | J. Vaughn 4 | D. Mobley 7 |
| March 8, 2026 | @ Georgia Tech Yellow Jackets ACC Tournament | L 64-81 | 12-18 | J. Vaughn 18 | J. Vaughn 4 | D. Mobley 8 |
