| November 15, 2027 | ALABAMA CRIMSON TIDE | L 75-79 | 0-1 | M. Shipley 23 | J. Blackwell 7 | C. Hamilton 7 |
| November 18, 2027 | VMI KEYDETS | W 69-58 | 1-1 | M. Shipley 17 | J. Blackwell 6 | J. East 9 |
| November 22, 2027 | FURMAN PALADINS | W 83-61 | 2-1 | M. Shipley 18 | M. Shipley 7 | C. Hamilton 8 |
| November 25, 2027 | @ Illinois Fighting Illini | L 65-74 | 2-2 | M. Shipley 13 | J. Blackwell 5 | C. Brooks 7 |
| November 29, 2027 | SOUTHERN ILLINOIS SALUKIS | W 77-66 | 3-2 | M. Shipley 21 | J. Blackwell 4 | J. East 7 |
| December 1, 2027 | MASS.-LOWELL RIVER HAWKS | W 92-80 | 4-2 | M. Shipley 17 | J. Tolliver 5 | A. Wilcox 5 |
| December 6, 2027 | TARLETON STATE TEXANS | L 58-64 | 4-3 | M. Shipley 18 | C. Brooks 2 | A. Hampton 10 |
| December 13, 2027 | BUCKNELL BISON | W 76-73 | 5-3 | A. Hampton 17 | M. Shipley 5 | A. Wilcox 9 |
| December 20, 2027 | LOUISIANA-LAFAYETTE RAGIN' CAJUNS (4-3, 2-1 Away) | - | | | | |
| December 26, 2027 | @ Wake Forest Demon Deacons (6-2, 0-0, 6-0 Home)* | - | | | | |
| December 28, 2027 | CLEMSON TIGERS (7-2, 0-0, 0-0 Away)* | - | | | | |
| January 2, 2028 | @ North Carolina Tar Heels (9-1, 0-0, 6-1 Home)* | - | | | | |
| January 4, 2028 | SYRACUSE ORANGE (3-5, 0-0, 0-0 Away)* | - | | | | |
| January 9, 2028 | @ Georgia Tech Yellow Jackets (8-1, 0-0, 4-0 Home)* | - | | | | |
| January 11, 2028 | NC-STATE WOLFPACK (5-2, 0-0, 0-0 Away)* | - | | | | |
| January 16, 2028 | DUKE BLUE DEVILS (6-4, 0-0, 0-2 Away)* | - | | | | |
| January 18, 2028 | LOUISVILLE CARDINALS (8-1, 0-0, 1-0 Away)* | - | | | | |
| January 23, 2028 | @ Florida State Seminoles (7-3, 0-0, 5-2 Home)* | - | | | | |
| January 25, 2028 | MIAMI (FL) HURRICANES (5-2, 0-0, 0-2 Away)* | - | | | | |
| January 30, 2028 | @ Virginia Cavaliers (9-1, 0-0, 4-0 Home)* | - | | | | |
| February 1, 2028 | @ Boston College Eagles (5-4, 0-0, 4-1 Home)* | - | | | | |
| February 6, 2028 | @ Notre Dame Fighting Irish (5-4, 0-0, 4-3 Home)* | - | | | | |
| February 8, 2028 | @ California Golden Bears (5-3, 0-0, 4-2 Home)* | - | | | | |
| February 13, 2028 | SOUTHERN METHODIST MUSTANGS (4-4, 0-0, 0-0 Away)* | - | | | | |
| February 15, 2028 | PITTSBURGH PANTHERS (9-2, 0-0, 0-1 Away)* | - | | | | |
| February 20, 2028 | STANFORD CARDINAL (6-2, 0-0, 0-1 Away)* | - | | | | |
| February 22, 2028 | @ Duke Blue Devils (6-4, 0-0, 4-1 Home)* | - | | | | |
| February 27, 2028 | WAKE FOREST DEMON DEACONS (6-2, 0-0, 0-1 Away)* | - | | | | |
| March 1, 2028 | @ Southern Methodist Mustangs (4-4, 0-0, 3-3 Home)* | - | | | | |
