| November 15, 2027 | ALABAMA CRIMSON TIDE | L 75-79 | 0-1 | M. Shipley 23 | J. Blackwell 7 | C. Hamilton 7 |
| November 18, 2027 | VMI KEYDETS | W 69-58 | 1-1 | M. Shipley 17 | J. Blackwell 6 | J. East 9 |
| November 22, 2027 | FURMAN PALADINS | W 83-61 | 2-1 | M. Shipley 18 | M. Shipley 7 | C. Hamilton 8 |
| November 25, 2027 | @ Illinois Fighting Illini | L 65-74 | 2-2 | M. Shipley 13 | J. Blackwell 5 | C. Brooks 7 |
| November 29, 2027 | SOUTHERN ILLINOIS SALUKIS | W 77-66 | 3-2 | M. Shipley 21 | J. Blackwell 4 | J. East 7 |
| December 1, 2027 | MASS.-LOWELL RIVER HAWKS | W 92-80 | 4-2 | M. Shipley 17 | J. Tolliver 5 | A. Wilcox 5 |
| December 6, 2027 | TARLETON STATE TEXANS | L 58-64 | 4-3 | M. Shipley 18 | C. Brooks 2 | A. Hampton 10 |
| December 13, 2027 | BUCKNELL BISON | W 76-73 | 5-3 | A. Hampton 17 | M. Shipley 5 | A. Wilcox 9 |
| December 20, 2027 | LOUISIANA-LAFAYETTE RAGIN' CAJUNS | L 67-83 | 5-4 | M. Shipley 19 | J. Blackwell 5 | M. Shipley 8 |
| December 26, 2027 | @ Wake Forest Demon Deacons* | W 91-79 | 6-4 | M. Shipley 19 | J. Blackwell 4 | A. Wilcox 6 |
| December 28, 2027 | CLEMSON TIGERS* | W 65-51 | 7-4 | M. Shipley 21 | J. Blackwell 6 | C. Brooks 7 |
| January 2, 2028 | @ #12 North Carolina Tar Heels* | L 55-72 | 7-5 | M. Shipley 17 | J. Blackwell 3 | M. Shipley 7 |
| January 4, 2028 | SYRACUSE ORANGE* | L 68-76 | 7-6 | M. Shipley 28 | J. Blackwell 4 | J. East 7 |
| January 9, 2028 | @ Georgia Tech Yellow Jackets* | L 88-93 | 7-7 | M. Shipley 34 | J. Blackwell 4 | A. Hampton 6 |
| January 11, 2028 | NC-STATE WOLFPACK* | W 74-62 | 8-7 | M. Shipley 23 | J. Tolliver 5 | C. Hamilton 12 |
| January 16, 2028 | #8 DUKE BLUE DEVILS* | L 61-72 | 8-8 | M. Shipley 18 | A. Wilcox 5 | J. Blackwell 5 |
| January 18, 2028 | #9 LOUISVILLE CARDINALS* | L 62-83 | 8-9 | M. Shipley 20 | J. East 2 | J. East 5 |
| January 23, 2028 | @ Florida State Seminoles* | W 77-70 | 9-9 | M. Shipley 27 | J. Blackwell 5 | C. Brooks 6 |
| January 25, 2028 | MIAMI (FL) HURRICANES* | W 77-49 | 10-9 | A. Hampton 16 | J. Blackwell 6 | M. Shipley 9 |
| January 30, 2028 | @ #8 Virginia Cavaliers* | L 73-85 | 10-10 | M. Shipley 26 | J. Blackwell 6 | J. East 6 |
| February 1, 2028 | @ Boston College Eagles* | L 65-70 | 10-11 | M. Shipley 12 | J. Blackwell 5 | C. Brooks 6 |
| February 6, 2028 | @ Notre Dame Fighting Irish* | L 71-88 | 10-12 | M. Shipley 16 | J. Blackwell 4 | M. Shipley 5 |
| February 8, 2028 | @ California Golden Bears* | L 63-72 | 10-13 | C. Hamilton 20 | J. Blackwell 3 | C. Hamilton 12 |
| February 13, 2028 | SOUTHERN METHODIST MUSTANGS* | W 83-75 | 11-13 | M. Shipley 16 | J. Blackwell 4 | A. Wilcox 10 |
| February 15, 2028 | #14 PITTSBURGH PANTHERS* | W 86-75 | 12-13 | M. Shipley 17 | J. Blackwell 5 | C. Brooks 7 |
| February 20, 2028 | STANFORD CARDINAL* | W 60-50 | 13-13 | C. Brooks 13 | J. Tolliver 3 | J. East 7 |
| February 22, 2028 | @ #7 Duke Blue Devils* | L 65-96 | 13-14 | M. Shipley 21 | J. East 5 | C. Brooks 7 |
| February 27, 2028 | WAKE FOREST DEMON DEACONS* | W 76-66 | 14-14 | C. Brooks 15 | J. Blackwell 10 | C. Brooks 9 |
| March 1, 2028 | @ Southern Methodist Mustangs* | W 76-65 | 15-14 | M. Shipley 20 | J. Blackwell 9 | A. Wilcox 8 |
| March 9, 2028 | STANFORD CARDINAL ACC Tournament | L 56-66 | 15-15 | J. Blackwell 13 | J. Blackwell 2 | C. Brooks 11 |
