| November 13, 2027 | YALE BULLDOGS Legends Classic | W 88-62 | 1-0 | R. Jenkins 31 | G. Jameson 3 | D. Sagester 10 |
| November 15, 2027 | @ #23 Creighton Blue Jays Legends Classic | L 82-85 | 1-1 | R. Jenkins 20 | R. Jenkins 9 | B. Cotton 9 |
| November 23, 2027 | LE MOYNE DOLPHINS | W 118-69 | 2-1 | T. Dondon 26 | G. Jameson 8 | T. Dondon 9 |
| November 26, 2027 | CAL ST. BAKERSFIELD ROADRUNNERS | W 91-82 | 3-1 | R. Jenkins 23 | G. Jameson 8 | D. Sagester 11 |
| November 30, 2027 | NEW MEXICO STATE AGGIES | W 89-64 | 4-1 | T. Dondon 27 | G. Jameson 4 | J. Arrington 7 |
| December 3, 2027 | MARSHALL THUNDERING HERD | W 92-65 | 5-1 | T. Dondon 36 | R. Jenkins 7 | R. Jenkins 10 |
| December 7, 2027 | BUFFALO BULLS | W 93-51 | 6-1 | R. Jenkins 30 | D. Sagester 7 | B. Cotton 10 |
| December 10, 2027 | ARKANSAS STATE RED WOLVES | W 95-79 | 7-1 | T. Dondon 24 | D. Sagester 8 | D. Sagester 11 |
| December 14, 2027 | MCNEESE STATE COWBOYS | W 109-76 | 8-1 | R. Jenkins 27 | R. Jenkins 4 | B. Cotton 12 |
| December 21, 2027 | @ Boise State Broncos | W 80-72 | 9-1 | T. Dondon 24 | R. Woods 5 | B. Cotton 11 |
| December 26, 2027 | #22 CLEMSON TIGERS* | W 94-75 | 10-1 | T. Dondon 32 | G. Jameson 10 | D. Sagester 10 |
| December 28, 2027 | #24 NORTH CAROLINA TAR HEELS* | W 109-97 | 11-1 | T. Dondon 27 | R. Jenkins 10 | D. Sagester 9 |
| January 2, 2028 | @ NC-State Wolfpack* | W 94-67 | 12-1 | R. Jenkins 24 | R. Jenkins 6 | D. Sagester 10 |
| January 4, 2028 | @ Stanford Cardinal* | W 106-101 OT | 13-1 | T. Dondon 24 | D. Sagester 7 | D. Sagester 12 |
| January 9, 2028 | NOTRE DAME FIGHTING IRISH* | W 98-76 | 14-1 | T. Dondon 25 | D. Sagester 11 | D. Sagester 14 |
| January 11, 2028 | @ Georgia Tech Yellow Jackets* | W 89-62 | 15-1 | R. Jenkins 28 | D. Sagester 7 | B. Cotton 11 |
| January 16, 2028 | @ Boston College Eagles* | W 101-89 | 16-1 | T. Dondon 34 | R. Jenkins 9 | R. Woods 9 |
| January 18, 2028 | WAKE FOREST DEMON DEACONS* | W 104-94 | 17-1 | T. Dondon 43 | D. Sagester 7 | D. Sagester 8 |
| January 23, 2028 | @ California Golden Bears* | L 85-94 | 17-2 | R. Jenkins 29 | D. Sagester 5 | B. Cotton 5 |
| January 25, 2028 | FLORIDA STATE SEMINOLES* | W 100-84 | 18-2 | R. Jenkins 27 | G. Jameson 9 | D. Sagester 12 |
| January 30, 2028 | VIRGINIA TECH HOKIES* | W 78-63 | 19-2 | T. Dondon 20 | R. Jenkins 5 | B. Cotton 6 |
| February 1, 2028 | @ #1 Duke Blue Devils* | L 96-106 | 19-3 | T. Dondon 28 | R. Jenkins 9 | R. Jenkins 7 |
| February 6, 2028 | @ #17 Syracuse Orange* | W 95-80 | 20-3 | R. Jenkins 34 | R. Jenkins 6 | D. Sagester 8 |
| February 8, 2028 | @ #11 Louisville Cardinals* | L 78-85 | 20-4 | T. Dondon 37 | R. Jenkins 9 | D. Sagester 13 |
| February 13, 2028 | MIAMI (FL) HURRICANES* | W 97-88 | 21-4 | T. Dondon 36 | R. Jenkins 6 | D. Sagester 12 |
| February 15, 2028 | SOUTHERN METHODIST MUSTANGS* | W 101-86 | 22-4 | R. Jenkins 41 | G. Jameson 6 | B. Cotton 11 |
| February 20, 2028 | PITTSBURGH PANTHERS* | W 110-75 | 23-4 | R. Jenkins 29 | R. Jenkins 6 | D. Sagester 8 |
| February 22, 2028 | @ Clemson Tigers* | L 70-83 | 23-5 | T. Dondon 20 | R. Jenkins 5 | D. Sagester 14 |
| February 27, 2028 | @ #23 North Carolina Tar Heels* | W 92-89 | 24-5 | T. Dondon 27 | D. Sagester 6 | D. Sagester 12 |
| March 1, 2028 | STANFORD CARDINAL* | W 116-79 | 25-5 | T. Dondon 35 | G. Jameson 9 | B. Cotton 15 |
| March 10, 2028 | TBD ACC Tournament | - | | | | |
