| November 15, 2027 | YOUNGSTOWN STATE PENGUINS | W 88-72 | 1-0 | A. Harper 29 | E. Baille 5 | A. Pogacnik 8 |
| November 19, 2027 | NEBRASKA CORNHUSKERS | L 64-81 | 1-1 | A. Pogacnik 18 | E. Baille 5 | R. Kittles 9 |
| November 21, 2027 | WAGNER SEAHAWKS | W 96-62 | 2-1 | W. Deane 24 | E. Baille 9 | A. Pogacnik 8 |
| November 26, 2027 | ELON PHOENIX | W 89-67 | 3-1 | A. Harper 21 | W. Deane 8 | R. Kittles 13 |
| December 1, 2027 | FAIRLEIGH DICKINSON KNIGHTS | W 79-62 | 4-1 | E. Baille 15 | E. Baille 6 | R. Kittles 8 |
| December 9, 2027 | VALPARAISO BEACONS Jimmy V Classic | W 81-67 | 5-1 | A. Pogacnik 17 | A. Pogacnik 4 | A. Harper 6 |
| December 10, 2027 | @ UCLA Bruins Jimmy V Classic | W 76-58 | 6-1 | A. Pogacnik 20 | R. Gauthier 5 | A. Pogacnik 10 |
| December 11, 2027 | @ #22 Clemson Tigers Jimmy V Classic | L 65-78 | 6-2 | A. Harper 17 | B. Weathers 5 | W. Deane 5 |
| December 13, 2027 | #6 BRIGHAM YOUNG COUGARS* | L 69-71 | 6-3 | W. Deane 16 | E. Baille 5 | A. Pogacnik 7 |
| December 17, 2027 | HOFSTRA PRIDE | W 76-72 | 7-3 | A. Harper 16 | W. Deane 3 | A. Harper 7 |
| December 21, 2027 | #20 MARQUETTE GOLDEN EAGLES | L 64-73 | 7-4 | E. Baille 20 | E. Baille 5 | A. Pogacnik 13 |
| December 28, 2027 | @ Baylor Bears* | W 77-63 | 8-4 | E. Baille 24 | E. Baille 3 | A. Harper 9 |
| December 30, 2027 | ARIZONA STATE SUN DEVILS* | W 84-78 OT | 9-4 | A. Pogacnik 29 | W. Deane 5 | A. Harper 13 |
| January 4, 2028 | @ #18 Houston Cougars* | L 48-63 | 9-5 | A. Harper 17 | E. Baille 3 | A. Pogacnik 9 |
| January 6, 2028 | TEXAS TECH RED RAIDERS* | L 50-69 | 9-6 | A. Harper 9 | B. Weathers 8 | R. Kittles 7 |
| January 11, 2028 | @ #3 Kansas Jayhawks* | L 58-94 | 9-7 | A. Harper 18 | E. Baille 3 | A. Harper 4 |
| January 13, 2028 | WEST VIRGINIA MOUNTAINEERS* | W 98-86 | 10-7 | E. Baille 19 | E. Baille 7 | A. Harper 6 |
| January 18, 2028 | @ Texas Christian Horned Frogs* | W 69-67 | 11-7 | W. Deane 18 | E. Baille 5 | R. Kittles 7 |
| January 20, 2028 | BAYLOR BEARS* | L 69-84 | 11-8 | A. Harper 14 | E. Baille 6 | R. Kittles 7 |
| January 25, 2028 | KANSAS STATE WILDCATS* | L 62-75 | 11-9 | A. Harper 11 | B. Weathers 3 | R. Kittles 14 |
| January 27, 2028 | @ Texas Tech Red Raiders* | L 73-83 | 11-10 | W. Deane 17 | E. Baille 2 | A. Pogacnik 9 |
| February 1, 2028 | OKLAHOMA STATE COWBOYS* | L 60-67 | 11-11 | A. Harper 16 | E. Baille 7 | A. Harper 10 |
| February 3, 2028 | @ Central Florida Knights* | L 68-75 | 11-12 | A. Harper 24 | E. Baille 5 | A. Harper 8 |
| February 8, 2028 | @ Kansas State Wildcats* | L 78-95 | 11-13 | W. Deane 18 | A. Pogacnik 4 | A. Harper 8 |
| February 10, 2028 | CINCINNATI BEARCATS* | L 61-72 | 11-14 | R. Kittles 18 | E. Baille 4 | A. Pogacnik 10 |
| February 13, 2028 | #9 IOWA STATE CYCLONES* | W 88-78 | 12-14 | E. Baille 23 | W. Deane 2 | A. Harper 8 |
| February 20, 2028 | @ Colorado Buffaloes* | L 80-96 | 12-15 | A. Harper 25 | B. Weathers 4 | A. Pogacnik 11 |
| February 22, 2028 | @ #16 Arizona Wildcats* | L 49-72 | 12-16 | A. Harper 11 | E. Baille 4 | A. Pogacnik 11 |
| February 24, 2028 | #2 BRIGHAM YOUNG COUGARS* | L 63-75 | 12-17 | B. Weathers 11 | B. Weathers 3 | K. Telly 8 |
| March 1, 2028 | CENTRAL FLORIDA KNIGHTS* | W 81-74 | 13-17 | A. Harper 15 | E. Baille 4 | A. Pogacnik 11 |
| March 3, 2028 | @ West Virginia Mountaineers* | W 84-76 | 14-17 | R. Kittles 15 | B. Weathers 5 | R. Kittles 7 |
| March 8, 2028 | ARIZONA STATE SUN DEVILS (13-16, 4-8 Away) Big 12 Tournament | - | | | | |
