| November 16, 2027 | CENTRAL FLORIDA KNIGHTS | L 68-75 | 0-1 | M. Jeter 18 | M. Jeter 5 | M. Jeter 5 |
| November 23, 2027 | DAYTON FLYERS | W 95-81 | 1-1 | M. Jeter 22 | M. Jeter 6 | A. Jackson 7 |
| November 26, 2027 | @ Providence Friars | W 85-65 | 2-1 | D. Hunter 15 | E. Diggs 7 | R. Kolder 8 |
| November 30, 2027 | @ #14 Purdue Boilermakers | L 88-101 | 2-2 | M. Jeter 25 | X. Dampier 3 | A. Jackson 5 |
| December 3, 2027 | ARKANSAS STATE RED WOLVES | W 82-63 | 3-2 | J. Parmer 22 | M. Jeter 6 | J. Parmer 7 |
| December 7, 2027 | MINNESOTA GOLDEN GOPHERS | W 93-88 | 4-2 | M. Jeter 32 | M. Jeter 5 | A. Jackson 6 |
| December 14, 2027 | MERCER BEARS | W 91-77 | 5-2 | M. Jeter 24 | M. Jeter 8 | M. Jeter 7 |
| December 21, 2027 | #11 HOUSTON COUGARS | W 97-94 | 6-2 | M. Jeter 27 | M. Jeter 7 | X. Dampier 8 |
| December 23, 2027 | CLEVELAND STATE VIKINGS Empire Classic | W 93-84 | 7-2 | M. Jeter 34 | M. Jeter 5 | D. Hunter 9 |
| December 24, 2027 | GRAND CANYON ANTELOPES Empire Classic | W 84-68 | 8-2 | M. Jeter 29 | M. Jeter 4 | D. Hunter 5 |
| December 25, 2027 | MCNEESE STATE COWBOYS Empire Classic | W 74-47 | 9-2 | R. Kolder 15 | M. Jeter 3 | X. Dampier 10 |
| December 26, 2027 | BOSTON COLLEGE EAGLES* | W 77-56 | 10-2 | M. Jeter 25 | M. Jeter 5 | M. Jeter 8 |
| December 28, 2027 | @ #14 Virginia Cavaliers* | L 97-109 | 10-3 | M. Jeter 21 | M. Jeter 7 | A. Jackson 7 |
| January 2, 2028 | @ Miami (FL) Hurricanes* | L 70-78 | 10-4 | D. Hunter 16 | M. Jeter 3 | D. Hunter 7 |
| January 4, 2028 | #1 DUKE BLUE DEVILS* | L 84-95 | 10-5 | M. Jeter 27 | M. Jeter 5 | X. Dampier 7 |
| January 9, 2028 | @ #21 Syracuse Orange* | W 77-76 | 11-5 | M. Jeter 26 | A. Jackson 4 | A. Jackson 6 |
| January 11, 2028 | #7 LOUISVILLE CARDINALS* | L 66-83 | 11-6 | M. Jeter 16 | M. Jeter 6 | J. Parmer 5 |
| January 16, 2028 | @ Georgia Tech Yellow Jackets* | W 79-65 | 12-6 | M. Jeter 35 | M. Jeter 5 | D. Hunter 7 |
| January 18, 2028 | CLEMSON TIGERS* | W 92-74 | 13-6 | M. Jeter 21 | M. Jeter 8 | M. Jeter 5 |
| January 23, 2028 | @ Florida State Seminoles* | W 89-86 | 14-6 | M. Jeter 17 | M. Jeter 5 | D. Hunter 9 |
| January 25, 2028 | @ Southern Methodist Mustangs* | L 79-84 | 14-7 | D. Hunter 14 | M. Jeter 7 | J. Parmer 5 |
| January 30, 2028 | PITTSBURGH PANTHERS* | W 96-75 | 15-7 | M. Jeter 17 | M. Jeter 7 | E. Diggs 6 |
| February 1, 2028 | @ Virginia Tech Hokies* | L 69-70 | 15-8 | M. Jeter 17 | J. Parmer 6 | D. Hunter 6 |
| February 6, 2028 | NC-STATE WOLFPACK* | W 72-59 | 16-8 | M. Jeter 16 | M. Jeter 3 | A. Jackson 7 |
| February 8, 2028 | STANFORD CARDINAL* | W 78-62 | 17-8 | M. Jeter 30 | E. Diggs 5 | D. Hunter 7 |
| February 13, 2028 | @ Notre Dame Fighting Irish* | L 65-81 | 17-9 | M. Jeter 27 | M. Jeter 3 | A. Jackson 6 |
| February 15, 2028 | @ California Golden Bears* | W 78-67 | 18-9 | M. Jeter 23 | M. Jeter 3 | X. Dampier 8 |
| February 20, 2028 | WAKE FOREST DEMON DEACONS* | W 77-65 | 19-9 | M. Jeter 30 | J. Parmer 4 | J. Parmer 8 |
| February 22, 2028 | GEORGIA TECH YELLOW JACKETS* | W 99-83 | 20-9 | M. Jeter 32 | M. Jeter 6 | A. Jackson 10 |
| February 27, 2028 | #11 VIRGINIA CAVALIERS* | L 89-92 | 20-10 | M. Jeter 26 | M. Jeter 7 | X. Dampier 10 |
| March 1, 2028 | @ Clemson Tigers* | L 66-71 | 20-11 | M. Jeter 13 | A. Jackson 3 | D. Hunter 7 |
| March 9, 2028 | TBD ACC Tournament | - | | | | |
