| November 13, 2027 | NORFOLK STATE SPARTANS | W 83-54 | 1-0 | E. Boythe 34 | T. Chouest 7 | E. Boythe 11 |
| November 16, 2027 | @ #17 North Carolina Tar Heels | W 75-68 | 2-0 | K. Strohm 17 | T. Chouest 6 | T. Cotton 12 |
| November 21, 2027 | RUTGERS SCARLET KNIGHTS Charleston Classic | W 84-68 | 3-0 | E. Boythe 25 | T. Cotton 4 | E. Boythe 9 |
| November 22, 2027 | @ Marquette Golden Eagles Charleston Classic | L 59-64 | 3-1 | E. Boythe 26 | J. Carney 3 | E. Boythe 21 |
| November 25, 2027 | @ Tennessee Volunteers | L 73-91 | 3-2 | T. Cotton 17 | J. Carney 5 | E. Boythe 5 |
| December 2, 2027 | BALL STATE CARDINALS | W 83-60 | 4-2 | T. Chouest 18 | T. Chouest 4 | T. Tennell 9 |
| December 7, 2027 | COASTAL CAROLINA CHANTICLEERS | W 85-66 | 5-2 | E. Boythe 47 | T. Chouest 5 | E. Boythe 12 |
| December 9, 2027 | DAVIDSON WILDCATS | W 79-65 | 6-2 | J. Carney 26 | E. Boythe 3 | K. Strohm 8 |
| December 16, 2027 | HIGH POINT PANTHERS | W 75-64 | 7-2 | E. Boythe 17 | T. Chouest 13 | E. Boythe 10 |
| December 19, 2027 | LE MOYNE DOLPHINS | W 85-74 | 8-2 | E. Boythe 33 | T. Chouest 8 | E. Boythe 18 |
| December 28, 2027 | @ Cincinnati Bearcats* | L 66-71 | 8-3 | E. Boythe 25 | T. Chouest 3 | E. Boythe 19 |
| December 30, 2027 | TEXAS TECH RED RAIDERS* | W 95-83 | 9-3 | T. Chouest 26 | T. Chouest 5 | E. Boythe 9 |
| January 4, 2028 | ARIZONA WILDCATS* | L 75-84 | 9-4 | J. Carney 20 | T. Chouest 5 | T. Chouest 6 |
| January 9, 2028 | @ Oklahoma State Cowboys* | L 47-69 | 9-5 | E. Boythe 17 | T. Chouest 5 | E. Boythe 21 |
| January 11, 2028 | @ Texas Christian Horned Frogs* | W 79-67 | 10-5 | E. Boythe 20 | T. Chouest 14 | E. Boythe 11 |
| January 13, 2028 | #19 HOUSTON COUGARS* | L 76-89 | 10-6 | E. Boythe 17 | E. Boythe 5 | E. Boythe 16 |
| January 18, 2028 | #3 BRIGHAM YOUNG COUGARS* | L 61-78 | 10-7 | E. Boythe 19 | J. Carney 4 | E. Boythe 8 |
| January 20, 2028 | @ #11 Iowa State Cyclones* | L 79-92 | 10-8 | E. Boythe 18 | T. Chouest 8 | E. Boythe 17 |
| January 25, 2028 | TEXAS CHRISTIAN HORNED FROGS* | W 84-66 | 11-8 | J. Carney 19 | T. Chouest 7 | E. Boythe 14 |
| January 30, 2028 | @ Kansas State Wildcats* | L 65-79 | 11-9 | E. Boythe 18 | T. Chouest 8 | E. Boythe 12 |
| February 1, 2028 | @ #3 Kansas Jayhawks* | L 71-89 | 11-10 | E. Boythe 22 | T. Chouest 7 | T. Tennell 5 |
| February 3, 2028 | UTAH UTES* | W 75-68 | 12-10 | T. Chouest 25 | T. Chouest 6 | T. Chouest 10 |
| February 8, 2028 | WEST VIRGINIA MOUNTAINEERS* | L 87-101 | 12-11 | J. Carney 16 | T. Chouest 6 | E. Boythe 7 |
| February 10, 2028 | @ Baylor Bears* | L 59-84 | 12-12 | E. Boythe 16 | T. Chouest 4 | E. Boythe 8 |
| February 15, 2028 | KANSAS STATE WILDCATS* | L 69-75 | 12-13 | K. Strohm 19 | T. Chouest 7 | E. Boythe 10 |
| February 17, 2028 | @ Arizona State Sun Devils* | L 68-78 | 12-14 | E. Boythe 20 | J. Carney 5 | E. Boythe 10 |
| February 22, 2028 | #5 KANSAS JAYHAWKS* | W 90-88 OT | 13-14 | E. Boythe 39 | T. Chouest 4 | E. Boythe 20 |
| February 24, 2028 | @ West Virginia Mountaineers* | L 74-99 | 13-15 | E. Boythe 23 | T. Cotton 3 | E. Boythe 9 |
| March 1, 2028 | @ Utah Utes* | L 74-81 | 13-16 | E. Boythe 18 | T. Chouest 6 | E. Boythe 10 |
| March 3, 2028 | COLORADO BUFFALOES* | W 87-81 | 14-16 | E. Boythe 22 | T. Chouest 6 | E. Boythe 11 |
| March 8, 2028 | @ Texas Christian Horned Frogs (16-15, 10-4 Home) Big 12 Tournament | - | | | | |
