| November 16, 2027 | @ #14 Michigan Wolverines | L 69-90 | 0-1 | N. Louis 17 | J. Tanner 5 | N. Louis 4 |
| November 22, 2027 | LOUISIANA-LAFAYETTE RAGIN' CAJUNS | W 99-73 | 1-1 | N. Louis 17 | J. Tanner 11 | N. Louis 8 |
| November 29, 2027 | LONGWOOD LANCERS | L 76-85 | 1-2 | J. Tanner 14 | J. Tanner 6 | G. Brown 9 |
| December 2, 2027 | @ Eastern Illinois Panthers | L 101-111 OT | 1-3 | N. Louis 28 | J. Tanner 9 | J. Butler 8 |
| December 6, 2027 | @ Oregon State Beavers | L 80-88 | 1-4 | S. Cox 28 | J. Tanner 4 | G. Brown 13 |
| December 8, 2027 | FLORIDA GULF COAST EAGLES | W 103-87 | 2-4 | S. Cox 30 | J. Tanner 5 | G. Brown 7 |
| December 13, 2027 | @ Holy Cross Crusaders | L 75-87 OT | 2-5 | S. Cox 21 | J. Tanner 7 | S. Cox 10 |
| December 16, 2027 | @ North Dakota St. Bison Battle 4 Atlantis | L 70-75 | 2-6 | N. Louis 22 | J. Tanner 6 | G. Brown 8 |
| December 20, 2027 | @ Belmont Bruins | W 78-70 | 3-6 | N. Louis 21 | J. Tanner 7 | G. Brown 12 |
| December 23, 2027 | @ Incarnate Word Cardinals | L 71-78 | 3-7 | N. Louis 17 | J. Tanner 6 | J. Clyburn 10 |
| December 27, 2027 | @ Mississippi Valley Delta Devils | L 64-75 | 3-8 | J. Butler 13 | J. Tanner 10 | N. Louis 5 |
| January 2, 2028 | MIAMI (OH) REDHAWKS* | W 86-75 | 4-8 | N. Louis 19 | J. Tanner 8 | J. Clyburn 8 |
| January 5, 2028 | MASSACHUSETTS MINUTEMEN* | W 79-75 | 5-8 | N. Louis 18 | J. Tanner 6 | G. Brown 9 |
| January 9, 2028 | @ Akron Zips* | L 72-88 | 5-9 | J. Tanner 19 | J. Tanner 5 | J. Clyburn 8 |
| January 12, 2028 | @ Kent State Golden Flashes* | L 67-79 | 5-10 | N. Louis 16 | J. Tanner 7 | J. Butler 8 |
| January 14, 2028 | @ Northern Illinois Huskies* | W 96-80 | 6-10 | J. Clyburn 17 | J. Tanner 10 | G. Brown 9 |
| January 16, 2028 | BUFFALO BULLS* | L 73-74 | 6-11 | J. Butler 20 | G. Brown 4 | G. Brown 5 |
| January 19, 2028 | @ Bowling Green State Falcons* | W 89-79 | 7-11 | G. Brown 21 | J. Tanner 4 | G. Brown 7 |
| January 23, 2028 | NORTHERN ILLINOIS HUSKIES* | W 91-72 | 8-11 | J. Butler 21 | G. Brown 4 | G. Brown 8 |
| January 26, 2028 | @ Miami (OH) RedHawks* | L 70-81 | 8-12 | T. Carlisle 13 | J. Tanner 9 | T. Carlisle 9 |
| January 30, 2028 | @ Central Michigan Chippewas* | W 77-70 | 9-12 | J. Tanner 18 | J. Butler 3 | J. Butler 8 |
| February 6, 2028 | BALL STATE CARDINALS* | W 78-70 | 10-12 | N. Louis 16 | J. Tanner 7 | G. Brown 6 |
| February 9, 2028 | @ Eastern Michigan Eagles* | W 85-72 | 11-12 | G. Brown 17 | J. Tanner 7 | G. Brown 7 |
| February 13, 2028 | @ Western Michigan Broncos* | W 83-69 | 12-12 | N. Louis 16 | J. Tanner 8 | G. Brown 9 |
| February 16, 2028 | OHIO BOBCATS* | W 74-71 | 13-12 | J. Tanner 21 | J. Tanner 5 | T. Carlisle 9 |
| February 20, 2028 | KENT STATE GOLDEN FLASHES* | L 76-78 | 13-13 | N. Louis 22 | G. Brown 4 | G. Brown 8 |
| February 23, 2028 | BOWLING GREEN STATE FALCONS* | W 85-75 | 14-13 | H. Deeter 17 | N. Louis 3 | G. Brown 6 |
| February 27, 2028 | AKRON ZIPS* | W 96-87 OT | 15-13 | N. Louis 18 | N. Louis 3 | J. Butler 7 |
| March 2, 2028 | @ Buffalo Bulls* | L 56-72 | 15-14 | J. Clyburn 12 | N. Louis 3 | J. Butler 7 |
| March 6, 2028 | OHIO BOBCATS (14-15, 8-9 Away) MAC Tournament | - | | | | |
