| November 15, 2027 | @ Clemson Tigers | W 96-90 OT | 1-0 | D. Hamilton 27 | T. Hobbs 8 | D. Hamilton 8 |
| November 19, 2027 | @ Portland State Vikings | W 91-79 | 2-0 | D. Hamilton 31 | T. Neterville 9 | K. Martinez 7 |
| November 22, 2027 | @ DePaul Blue Demons | L 60-78 | 2-1 | D. Hamilton 14 | T. Neterville 4 | B. Smith 8 |
| November 25, 2027 | @ Louisiana State Fighting Tigers ESPN Events Invitational | W 80-60 | 3-1 | B. Smith 20 | T. Neterville 8 | B. Smith 9 |
| November 26, 2027 | @ #19 Creighton Blue Jays ESPN Events Invitational | L 74-78 | 3-2 | T. Neterville 19 | L. Williams 4 | K. Martinez 8 |
| November 30, 2027 | @ Oklahoma State Cowboys | L 61-78 | 3-3 | M. Lewis 11 | T. Hobbs 4 | B. Smith 7 |
| December 6, 2027 | @ North Dakota Fighting Hawks | W 79-65 | 4-3 | T. Neterville 17 | T. Neterville 3 | B. Smith 8 |
| December 9, 2027 | COLUMBIA LIONS | W 90-77 | 5-3 | B. Smith 19 | D. Hamilton 4 | B. Smith 6 |
| December 14, 2027 | @ Montana State Bobcats | L 74-87 | 5-4 | T. Neterville 17 | T. Neterville 7 | K. Martinez 5 |
| December 20, 2027 | @ Wisconsin Badgers | L 56-71 | 5-5 | D. Hamilton 11 | M. Mixson 3 | K. Martinez 8 |
| December 26, 2027 | @ Eastern Michigan Eagles* | W 78-72 | 6-5 | B. Smith 19 | T. Neterville 3 | K. Martinez 14 |
| December 29, 2027 | @ Northern Illinois Huskies* | L 69-80 | 6-6 | T. Neterville 17 | T. Hobbs 4 | B. Smith 8 |
| January 2, 2028 | BUFFALO BULLS* | W 77-76 | 7-6 | D. Hamilton 17 | D. Hamilton 7 | K. Martinez 9 |
| January 5, 2028 | CENTRAL MICHIGAN CHIPPEWAS* | L 62-72 | 7-7 | L. Williams 13 | T. Neterville 6 | L. Williams 5 |
| January 9, 2028 | AKRON ZIPS* | W 67-58 | 8-7 | D. Hamilton 13 | T. Neterville 6 | K. Martinez 9 |
| January 12, 2028 | @ Miami (OH) RedHawks* | W 75-66 | 9-7 | K. Martinez 14 | T. Hobbs 5 | B. Smith 7 |
| January 16, 2028 | BOWLING GREEN STATE FALCONS* | L 72-87 | 9-8 | L. Williams 15 | T. Neterville 7 | L. Williams 6 |
| January 19, 2028 | @ Ohio Bobcats* | L 75-88 | 9-9 | B. Smith 10 | T. Darden 4 | K. Martinez 8 |
| January 23, 2028 | @ Ball State Cardinals* | W 83-70 | 10-9 | T. Neterville 21 | T. Neterville 7 | M. Lewis 8 |
| January 26, 2028 | @ Bowling Green State Falcons* | L 76-88 | 10-10 | D. Hamilton 13 | T. Neterville 5 | D. Hamilton 6 |
| January 30, 2028 | OHIO BOBCATS* | L 63-71 | 10-11 | T. Neterville 9 | K. Martinez 3 | K. Martinez 9 |
| February 2, 2028 | BALL STATE CARDINALS* | W 80-78 | 11-11 | T. Darden 18 | T. Neterville 4 | K. Martinez 11 |
| February 6, 2028 | MIAMI (OH) REDHAWKS* | W 68-58 | 12-11 | K. Martinez 15 | T. Neterville 4 | L. Williams 10 |
| February 9, 2028 | @ Kent State Golden Flashes* | W 68-61 | 13-11 | K. Martinez 14 | T. Neterville 4 | K. Martinez 9 |
| February 13, 2028 | @ Buffalo Bulls* | L 63-69 | 13-12 | T. Darden 22 | T. Neterville 5 | K. Martinez 13 |
| February 16, 2028 | @ Central Michigan Chippewas* | L 77-93 | 13-13 | D. Hamilton 22 | T. Hobbs 6 | K. Martinez 7 |
| February 20, 2028 | EASTERN MICHIGAN EAGLES* | L 73-80 | 13-14 | T. Darden 16 | M. Mixson 4 | L. Williams 8 |
| February 23, 2028 | NORTHERN ILLINOIS HUSKIES* | L 67-78 | 13-15 | T. Darden 20 | T. Neterville 2 | T. Neterville 6 |
| February 27, 2028 | KENT STATE GOLDEN FLASHES* | L 59-69 | 13-16 | D. Hamilton 16 | T. Neterville 5 | D. Hamilton 7 |
| March 2, 2028 | @ Western Michigan Broncos* | W 74-61 | 14-16 | D. Hamilton 11 | T. Neterville 5 | K. Martinez 8 |
| March 7, 2028 | @ Western Michigan Broncos MAC Tournament | W 81-71 | 15-16 | L. Williams 17 | T. Neterville 3 | K. Martinez 8 |
| March 8, 2028 | @ Bowling Green State Falcons MAC Tournament | L 72-88 | 15-17 | T. Darden 13 | L. Williams 4 | K. Martinez 7 |
