| November 13, 2027 | #20 ALABAMA CRIMSON TIDE | L 85-96 | 0-1 | L. Towns 19 | D. Blackman 8 | B. Burton 8 |
| November 14, 2027 | @ Delaware Fightin' Blue Hens | L 70-76 | 0-2 | L. Towns 18 | D. Blackman 5 | D. Autry 10 |
| November 19, 2027 | MONMOUTH HAWKS | L 60-77 | 0-3 | J. Nilson 12 | D. Blackman 3 | B. Burton 9 |
| November 23, 2027 | #23 CREIGHTON BLUE JAYS | L 74-84 | 0-4 | M. Akins 16 | D. Blackman 7 | L. Towns 6 |
| November 25, 2027 | @ Illinois State Redbirds | L 66-74 | 0-5 | L. Towns 17 | D. Blackman 5 | L. Towns 8 |
| November 29, 2027 | SOUTH CAROLINA GAMECOCKS | L 85-96 | 0-6 | L. Towns 30 | D. Blackman 6 | D. Autry 6 |
| December 6, 2027 | MOREHEAD STATE EAGLES | L 80-82 | 0-7 | L. Towns 21 | D. Blackman 9 | D. Autry 7 |
| December 14, 2027 | @ Princeton Tigers | L 66-74 | 0-8 | L. Towns 17 | D. Blackman 6 | B. Burton 9 |
| December 16, 2027 | WESTERN ILLINOIS LEATHERNECKS | W 74-62 | 1-8 | L. Towns 26 | D. Blackman 10 | B. Burton 7 |
| December 19, 2027 | FAIRLEIGH DICKINSON KNIGHTS | W 92-76 | 2-8 | L. Towns 22 | M. Akins 5 | J. Nilson 7 |
| December 24, 2027 | @ Dartmouth Big Green | W 81-68 | 3-8 | L. Towns 20 | D. Blackman 5 | B. Burton 9 |
| January 2, 2028 | @ Alabama-Birmingham Blazers* | L 60-89 | 3-9 | L. Towns 21 | L. Towns 2 | L. Towns 5 |
| January 9, 2028 | @ Rice Owls* | L 67-77 | 3-10 | L. Towns 19 | L. Towns 6 | J. Nilson 7 |
| January 12, 2028 | MEMPHIS TIGERS* | L 59-79 | 3-11 | B. Burton 11 | J. Nilson 4 | J. Nilson 9 |
| January 14, 2028 | @ East Carolina Pirates* | W 73-65 | 4-11 | D. Blackman 13 | K. Hatcher 4 | J. Nilson 8 |
| January 16, 2028 | @ Tulsa Golden Hurricanes* | L 65-88 | 4-12 | J. Nilson 13 | D. Blackman 7 | J. Nilson 5 |
| January 19, 2028 | CHARLOTTE 49ERS* | W 74-66 | 5-12 | J. Nilson 19 | D. Blackman 5 | J. Nilson 8 |
| January 23, 2028 | EAST CAROLINA PIRATES* | W 77-59 | 6-12 | L. Towns 17 | D. Blackman 7 | L. Towns 7 |
| January 26, 2028 | @ Texas-San Antonio Roadrunners* | L 98-104 | 6-13 | L. Towns 22 | D. Blackman 6 | J. Nilson 8 |
| January 28, 2028 | @ Charlotte 49ers* | L 72-93 | 6-14 | L. Towns 18 | D. Blackman 4 | D. Autry 6 |
| January 30, 2028 | NORTH TEXAS MEAN GREEN* | L 91-96 | 6-15 | L. Towns 30 | D. Blackman 7 | D. Autry 13 |
| February 2, 2028 | @ Wichita State Shockers* | L 60-77 | 6-16 | L. Towns 16 | D. Blackman 4 | D. Autry 9 |
| February 6, 2028 | @ #18 Memphis Tigers* | L 63-89 | 6-17 | L. Towns 24 | D. Blackman 5 | B. Burton 5 |
| February 9, 2028 | FLORIDA ATLANTIC OWLS* | L 58-79 | 6-18 | L. Towns 25 | D. Blackman 6 | B. Burton 6 |
| February 13, 2028 | TULANE GREEN WAVE* | W 94-88 | 7-18 | M. Akins 22 | D. Blackman 10 | D. Blackman 7 |
| February 16, 2028 | @ South Florida Bulls* | W 76-69 | 8-18 | L. Towns 27 | D. Blackman 7 | B. Burton 11 |
| February 20, 2028 | ALABAMA-BIRMINGHAM BLAZERS* | L 80-87 | 8-19 | L. Towns 20 | D. Blackman 9 | K. Hatcher 5 |
| February 27, 2028 | RICE OWLS* | W 93-79 | 9-19 | L. Towns 36 | D. Blackman 7 | K. Hatcher 8 |
| March 2, 2028 | TULSA GOLDEN HURRICANES* | W 92-68 | 10-19 | L. Towns 20 | D. Blackman 7 | D. Autry 11 |
| March 7, 2028 | TULANE GREEN WAVE (13-16, 2-11 Away) AAC Tournament | - | | | | |
