| November 16, 2027 | @ #1 Duke Blue Devils | W 80-78 | 1-0 | J. Janes 18 | M. Fields 4 | R. Richardson 7 |
| November 22, 2027 | RADFORD HIGHLANDERS | W 76-75 | 2-0 | M. Fields 21 | R. Richardson 3 | K. DeWitt 13 |
| November 25, 2027 | PRESBYTERIAN BLUE HOSE | W 86-76 | 3-0 | T. Pringle 17 | M. Fields 7 | K. DeWitt 10 |
| November 28, 2027 | WYOMING COWBOYS | W 100-66 | 4-0 | T. Pringle 19 | N. Green 7 | M. Bush 11 |
| December 5, 2027 | @ Fresno State Bulldogs | W 93-70 | 5-0 | J. Janes 22 | N. Green 5 | J. Janes 6 |
| December 9, 2027 | BINGHAMTON BEARCATS | L 69-77 | 5-1 | M. Bush 18 | N. Green 3 | M. Bush 10 |
| December 12, 2027 | @ Vanderbilt Commodores | L 60-72 | 5-2 | M. Bush 19 | N. Green 4 | T. Pringle 7 |
| December 16, 2027 | BUFFALO BULLS Diamond Head Classic | W 82-67 | 6-2 | R. Richardson 14 | N. Green 6 | K. DeWitt 12 |
| December 17, 2027 | @ Pittsburgh Panthers Diamond Head Classic | W 91-68 | 7-2 | K. DeWitt 15 | N. Green 7 | R. Richardson 8 |
| December 18, 2027 | @ #16 Kentucky Wildcats Diamond Head Classic | W 66-65 | 8-2 | T. Pringle 19 | N. Green 3 | K. DeWitt 6 |
| December 19, 2027 | @ Louisiana State Fighting Tigers | L 53-72 | 8-3 | M. Bush 13 | J. Janes 4 | J. Janes 6 |
| December 26, 2027 | @ Texas Tech Red Raiders* | L 72-74 | 8-4 | T. Pringle 12 | N. Green 4 | M. Bush 7 |
| December 30, 2027 | WEST VIRGINIA MOUNTAINEERS* | W 86-75 | 9-4 | M. Bush 15 | N. Green 7 | M. Bush 8 |
| January 2, 2028 | #3 KANSAS JAYHAWKS* | L 63-90 | 9-5 | R. Richardson 17 | N. Green 9 | M. Bush 5 |
| January 6, 2028 | @ #10 Iowa State Cyclones* | L 88-106 | 9-6 | T. Pringle 19 | N. Green 4 | M. Bush 7 |
| January 11, 2028 | CENTRAL FLORIDA KNIGHTS* | L 67-79 | 9-7 | M. Bush 15 | N. Green 6 | M. Bush 7 |
| January 13, 2028 | @ Colorado Buffaloes* | L 60-63 | 9-8 | T. Pringle 20 | M. Fields 4 | M. Bush 12 |
| January 18, 2028 | UTAH UTES* | L 67-69 | 9-9 | M. Bush 15 | M. Bush 3 | T. Pringle 8 |
| January 20, 2028 | @ Cincinnati Bearcats* | L 78-91 | 9-10 | J. Janes 15 | N. Green 6 | M. Bush 8 |
| January 25, 2028 | @ Central Florida Knights* | L 66-84 | 9-11 | M. Fields 17 | N. Green 5 | T. Pringle 3 |
| January 27, 2028 | ARIZONA STATE SUN DEVILS* | W 91-73 | 10-11 | T. Pringle 14 | J. Janes 4 | R. Richardson 8 |
| February 1, 2028 | TEXAS TECH RED RAIDERS* | W 79-74 | 11-11 | K. DeWitt 14 | J. Janes 4 | M. Bush 9 |
| February 3, 2028 | @ Oklahoma State Cowboys* | L 79-99 | 11-12 | J. Janes 14 | T. Pringle 6 | T. Pringle 5 |
| February 6, 2028 | BAYLOR BEARS* | W 83-65 | 12-12 | M. Bush 19 | N. Green 4 | M. Bush 12 |
| February 10, 2028 | @ #16 Arizona Wildcats* | L 62-82 | 12-13 | J. Janes 17 | M. Fields 3 | K. DeWitt 9 |
| February 15, 2028 | @ #2 Brigham Young Cougars* | L 59-80 | 12-14 | T. Pringle 12 | N. Green 3 | M. Bush 6 |
| February 17, 2028 | HOUSTON COUGARS* | W 89-79 | 13-14 | M. Bush 24 | M. Fields 5 | M. Bush 10 |
| February 20, 2028 | @ Arizona State Sun Devils* | W 74-70 | 14-14 | T. Pringle 14 | N. Green 5 | M. Bush 12 |
| February 24, 2028 | KANSAS STATE WILDCATS* | W 92-81 | 15-14 | M. Fields 21 | N. Green 5 | K. DeWitt 9 |
| February 27, 2028 | CINCINNATI BEARCATS* | W 92-89 | 16-14 | J. Janes 20 | B. Bass 4 | T. Pringle 4 |
| March 3, 2028 | @ Baylor Bears* | L 78-88 | 16-15 | M. Bush 28 | N. Green 6 | K. DeWitt 6 |
| March 8, 2028 | CENTRAL FLORIDA KNIGHTS (14-16, 2-10 Away) Big 12 Tournament | - | | | | |
