| November 16, 2027 | SETON HALL PIRATES | W 77-50 | 1-0 | R. Boone 15 | L. Johnson 5 | J. Sykes 7 |
| November 19, 2027 | LONG BEACH STATE SHARKS | W 81-45 | 2-0 | J. Sykes 19 | L. Johnson 3 | J. Sykes 9 |
| November 21, 2027 | IONA GAELS Charleston Classic | W 77-49 | 3-0 | J. Sykes 27 | L. Johnson 11 | J. Sykes 7 |
| November 22, 2027 | RHODE ISLAND RAMS Charleston Classic | W 78-74 OT | 4-0 | L. Johnson 15 | C. Daniels 6 | R. Boone 8 |
| November 23, 2027 | @ Marquette Golden Eagles Charleston Classic | W 78-61 | 5-0 | J. Sykes 17 | L. Johnson 8 | J. Sykes 8 |
| November 26, 2027 | @ #3 Brigham Young Cougars | L 76-79 | 5-1 | R. Boone 15 | L. Johnson 8 | J. Sykes 8 |
| November 30, 2027 | BUFFALO BULLS | W 83-45 | 6-1 | J. Sykes 16 | L. Johnson 4 | R. Boone 11 |
| December 3, 2027 | LAFAYETTE LEOPARDS | W 96-80 | 7-1 | T. Degala 23 | B. Stuart 6 | T. Degala 6 |
| December 7, 2027 | AUBURN TIGERS | L 62-71 | 7-2 | J. Sykes 15 | L. Johnson 5 | T. Degala 8 |
| December 13, 2027 | GEORGETOWN HOYAS | W 82-73 | 8-2 | T. Mance 20 | T. Degala 3 | T. Mance 11 |
| December 21, 2027 | CENTRAL MICHIGAN CHIPPEWAS | W 90-69 | 9-2 | J. Sykes 18 | L. Johnson 6 | J. Sykes 8 |
| December 26, 2027 | GEORGIA TECH YELLOW JACKETS* | W 82-65 | 10-2 | T. Mance 21 | L. Johnson 8 | T. Degala 8 |
| December 28, 2027 | STANFORD CARDINAL* | W 83-70 | 11-2 | J. Sykes 22 | L. Johnson 8 | T. Mance 8 |
| January 2, 2028 | @ Southern Methodist Mustangs* | W 95-85 | 12-2 | J. Sykes 23 | T. Degala 5 | T. Mance 6 |
| January 4, 2028 | @ Virginia Tech Hokies* | W 81-58 | 13-2 | T. Mance 19 | L. Johnson 4 | R. Boone 12 |
| January 9, 2028 | NORTH CAROLINA TAR HEELS* | L 76-77 | 13-3 | L. Johnson 22 | T. Degala 5 | J. Sykes 10 |
| January 11, 2028 | NOTRE DAME FIGHTING IRISH* | W 71-57 | 14-3 | T. Mance 27 | L. Johnson 8 | R. Boone 10 |
| January 16, 2028 | @ Florida State Seminoles* | W 88-86 | 15-3 | T. Mance 18 | T. Mance 5 | T. Mance 12 |
| January 18, 2028 | BOSTON COLLEGE EAGLES* | W 89-84 OT | 16-3 | J. Sykes 22 | B. Stuart 7 | T. Mance 9 |
| January 23, 2028 | @ #10 Louisville Cardinals* | L 67-89 | 16-4 | R. Boone 15 | T. Mance 4 | T. Mance 10 |
| January 25, 2028 | @ Wake Forest Demon Deacons* | W 85-79 | 17-4 | T. Degala 23 | L. Johnson 7 | R. Boone 10 |
| January 30, 2028 | @ Miami (FL) Hurricanes* | L 58-71 | 17-5 | T. Mance 19 | J. Sykes 4 | J. Sykes 7 |
| February 1, 2028 | @ California Golden Bears* | W 77-65 | 18-5 | T. Degala 18 | L. Johnson 6 | R. Boone 7 |
| February 6, 2028 | #10 VIRGINIA CAVALIERS* | L 80-95 | 18-6 | T. Degala 23 | B. Stuart 6 | J. Sykes 11 |
| February 8, 2028 | NC-STATE WOLFPACK* | W 82-63 | 19-6 | T. Degala 24 | L. Johnson 13 | J. Sykes 7 |
| February 13, 2028 | @ #1 Duke Blue Devils* | L 54-80 | 19-7 | J. Sykes 10 | L. Johnson 4 | R. Boone 6 |
| February 15, 2028 | @ Pittsburgh Panthers* | W 78-68 | 20-7 | T. Mance 25 | L. Johnson 8 | J. Sykes 9 |
| February 20, 2028 | CLEMSON TIGERS* | W 80-59 | 21-7 | T. Mance 20 | L. Johnson 10 | T. Mance 7 |
| February 22, 2028 | VIRGINIA TECH HOKIES* | W 79-60 | 22-7 | T. Mance 19 | L. Johnson 5 | T. Mance 9 |
| February 27, 2028 | @ Georgia Tech Yellow Jackets* | W 74-69 | 23-7 | T. Degala 16 | T. Degala 3 | J. Sykes 8 |
| March 1, 2028 | SOUTHERN METHODIST MUSTANGS* | W 91-65 | 24-7 | J. Sykes 18 | L. Johnson 6 | T. Mance 13 |
| March 10, 2028 | TBD ACC Tournament | - | | | | |
