| November 18, 2027 | CENTRAL MICHIGAN CHIPPEWAS | W 73-69 | 1-0 | J. Armstrong 21 | L. Brady 4 | J. Armstrong 8 |
| November 21, 2027 | @ Baylor Bears WSSN Classic | W 83-71 | 2-0 | J. Armstrong 20 | L. Brady 10 | L. Brady 6 |
| November 22, 2027 | @ #11 Connecticut Huskies WSSN Classic | L 73-96 | 2-1 | J. Armstrong 31 | L. Brady 5 | R. Brady 9 |
| November 25, 2027 | SO. CAROLINA UPSTATE SPARTANS | L 60-66 | 2-2 | L. Brady 13 | L. Brady 7 | J. Armstrong 11 |
| November 29, 2027 | VALPARAISO BEACONS | L 60-67 | 2-3 | R. Brady 18 | B. Burrough 3 | L. Brady 7 |
| December 1, 2027 | #9 IOWA STATE CYCLONES | L 92-111 | 2-4 | J. Armstrong 21 | B. Burrough 4 | R. Brady 12 |
| December 6, 2027 | NJIT HIGHLANDERS | W 81-74 | 3-4 | R. Brady 25 | K. Sessoms 5 | R. Brady 11 |
| December 10, 2027 | PENN STATE NITTANY LIONS | W 75-64 | 4-4 | L. Brady 15 | J. Armstrong 4 | K. Sessoms 11 |
| December 21, 2027 | COASTAL CAROLINA CHANTICLEERS | L 61-69 | 4-5 | J. Armstrong 15 | R. Brady 4 | R. Brady 9 |
| December 24, 2027 | TOWSON TIGERS | W 71-60 | 5-5 | J. Armstrong 17 | B. Burrough 3 | L. Brady 10 |
| December 26, 2027 | @ Wake Forest Demon Deacons* | L 81-95 | 5-6 | J. Armstrong 22 | L. Brady 6 | R. Brady 11 |
| December 28, 2027 | @ Syracuse Orange* | L 70-83 | 5-7 | J. Armstrong 18 | L. Brady 5 | K. Sessoms 7 |
| January 2, 2028 | FLORIDA STATE SEMINOLES* | L 74-75 | 5-8 | L. Brady 15 | L. Brady 4 | R. Brady 13 |
| January 4, 2028 | #12 VIRGINIA CAVALIERS* | L 101-106 OT | 5-9 | I. Humphrey 22 | R. Brady 5 | J. Armstrong 11 |
| January 9, 2028 | #7 LOUISVILLE CARDINALS* | L 84-98 | 5-10 | J. Armstrong 23 | L. Brady 5 | J. Armstrong 9 |
| January 11, 2028 | BOSTON COLLEGE EAGLES* | L 82-90 | 5-11 | R. Brady 20 | L. Brady 3 | I. Humphrey 10 |
| January 16, 2028 | @ NC-State Wolfpack* | L 53-71 | 5-12 | J. Armstrong 11 | L. Brady 2 | R. Brady 10 |
| January 18, 2028 | SOUTHERN METHODIST MUSTANGS* | W 100-76 | 6-12 | J. Armstrong 22 | L. Brady 5 | R. Brady 14 |
| January 23, 2028 | GEORGIA TECH YELLOW JACKETS* | W 92-75 | 7-12 | R. Brady 22 | L. Brady 5 | R. Brady 11 |
| January 25, 2028 | #1 DUKE BLUE DEVILS* | L 76-83 | 7-13 | L. Brady 14 | L. Brady 6 | R. Brady 8 |
| January 30, 2028 | @ Clemson Tigers* | L 58-75 | 7-14 | J. Armstrong 20 | L. Brady 4 | L. Brady 7 |
| February 1, 2028 | @ Pittsburgh Panthers* | W 81-79 | 8-14 | R. Brady 17 | L. Brady 6 | R. Brady 12 |
| February 6, 2028 | NOTRE DAME FIGHTING IRISH* | W 80-70 | 9-14 | J. Armstrong 29 | L. Brady 6 | I. Humphrey 11 |
| February 8, 2028 | @ North Carolina Tar Heels* | L 62-78 | 9-15 | J. Armstrong 16 | B. Burrough 3 | T. Larson 14 |
| February 13, 2028 | @ Virginia Tech Hokies* | W 84-75 | 10-15 | J. Armstrong 22 | L. Brady 4 | I. Humphrey 8 |
| February 15, 2028 | MIAMI (FL) HURRICANES* | L 87-97 | 10-16 | L. Brady 23 | L. Brady 9 | K. Sessoms 7 |
| February 20, 2028 | CALIFORNIA GOLDEN BEARS* | L 64-73 | 10-17 | K. Sessoms 12 | K. Sessoms 4 | R. Brady 11 |
| February 22, 2028 | @ Miami (FL) Hurricanes* | L 68-85 | 10-18 | I. Humphrey 14 | L. Brady 4 | R. Brady 8 |
| February 27, 2028 | @ #1 Duke Blue Devils* | L 77-96 | 10-19 | J. Armstrong 23 | B. Burrough 4 | B. Burrough 9 |
| March 1, 2028 | @ #11 Virginia Cavaliers* | L 79-116 | 10-20 | J. Armstrong 21 | B. Burrough 4 | J. Armstrong 8 |
| March 8, 2028 | @ NC-State Wolfpack (17-13, 14-3 Home) ACC Tournament | - | | | | |
