| November 16, 2027 | NEW HAVEN CHARGERS | W 63-58 | 1-0 | T. Freymond 17 | T. Freymond 3 | J. Martin 11 |
| November 19, 2027 | EAST TENNESSEE STATE BUCCANEERS | W 71-61 | 2-0 | T. Freymond 18 | B. Chambers 2 | J. Martin 8 |
| November 23, 2027 | @ Vanderbilt Commodores | L 44-60 | 2-1 | J. Martin 9 | E. Samuel 3 | J. Martin 9 |
| November 25, 2027 | SOUTHERN ILLINOIS SALUKIS Paradise Jam | W 75-68 | 3-1 | J. Martin 23 | H. Duncan 5 | B. Chambers 9 |
| November 26, 2027 | @ Milwaukee Panthers Paradise Jam | W 74-70 | 4-1 | T. Freymond 17 | H. Duncan 7 | T. Freymond 7 |
| November 27, 2027 | @ St. Thomas Tommies Paradise Jam | W 130-124 OT | 5-1 | A. Moore 25 | H. Duncan 4 | B. Chambers 7 |
| November 30, 2027 | TEXAS-SAN ANTONIO ROADRUNNERS | L 64-87 | 5-2 | J. Martin 15 | A. Moore 6 | T. Freymond 7 |
| December 2, 2027 | MASSACHUSETTS MINUTEMEN | W 82-74 | 6-2 | E. Samuel 15 | H. Duncan 3 | H. Duncan 8 |
| December 7, 2027 | LINDENWOOD LIONS | W 82-66 | 7-2 | B. Chambers 18 | T. Freymond 8 | J. Martin 9 |
| December 14, 2027 | BUCKNELL BISON | W 65-54 | 8-2 | E. Samuel 14 | H. Duncan 5 | H. Duncan 8 |
| December 21, 2027 | WAKE FOREST DEMON DEACONS | L 74-75 | 8-3 | T. Freymond 13 | T. Freymond 4 | T. Freymond 10 |
| December 26, 2027 | @ Georgetown Hoyas* | L 63-69 | 8-4 | J. Martin 15 | H. Duncan 6 | J. Martin 9 |
| December 30, 2027 | SETON HALL PIRATES* | W 75-55 | 9-4 | A. Moore 12 | T. Cornell 3 | E. Samuel 7 |
| January 2, 2028 | @ Villanova Wildcats* | L 46-71 | 9-5 | T. Freymond 11 | B. Chambers 5 | J. Martin 7 |
| January 4, 2028 | #25 MARQUETTE GOLDEN EAGLES* | L 76-83 | 9-6 | T. Freymond 16 | H. Duncan 4 | E. Samuel 8 |
| January 6, 2028 | #16 CREIGHTON BLUE JAYS* | L 68-74 | 9-7 | T. Freymond 22 | H. Duncan 4 | J. Martin 9 |
| January 11, 2028 | @ #9 Connecticut Huskies* | L 74-91 | 9-8 | B. Chambers 13 | H. Duncan 5 | J. Martin 10 |
| January 13, 2028 | @ DePaul Blue Demons* | L 71-95 | 9-9 | H. Duncan 14 | H. Duncan 3 | T. Freymond 5 |
| January 18, 2028 | PROVIDENCE FRIARS* | L 69-76 | 9-10 | T. Freymond 18 | T. Freymond 3 | T. Freymond 11 |
| January 23, 2028 | @ Marquette Golden Eagles* | L 71-92 | 9-11 | T. Freymond 12 | K. Garner 4 | N. Stringer 5 |
| January 27, 2028 | XAVIER MUSKETEERS* | L 76-85 | 9-12 | T. Freymond 17 | J. Martin 3 | J. Martin 5 |
| January 30, 2028 | BUTLER BULLDOGS* | W 64-60 | 10-12 | T. Freymond 17 | B. Chambers 5 | T. Freymond 9 |
| February 1, 2028 | @ #13 Creighton Blue Jays* | L 70-79 | 10-13 | T. Freymond 17 | H. Duncan 5 | E. Samuel 10 |
| February 3, 2028 | @ Seton Hall Pirates* | L 62-85 | 10-14 | T. Freymond 15 | A. Moore 5 | T. Freymond 6 |
| February 8, 2028 | DEPAUL BLUE DEMONS* | W 93-83 | 11-14 | E. Samuel 24 | H. Duncan 6 | H. Duncan 8 |
| February 10, 2028 | #9 CONNECTICUT HUSKIES* | L 69-95 | 11-15 | H. Duncan 17 | H. Duncan 2 | E. Samuel 9 |
| February 15, 2028 | @ Xavier Musketeers* | L 70-83 | 11-16 | T. Freymond 18 | H. Duncan 3 | T. Freymond 10 |
| February 17, 2028 | @ Butler Bulldogs* | W 59-48 | 12-16 | H. Duncan 13 | T. Freymond 4 | J. Martin 9 |
| February 22, 2028 | VILLANOVA WILDCATS* | W 87-79 OT | 13-16 | T. Freymond 22 | E. Samuel 5 | T. Freymond 9 |
| February 24, 2028 | GEORGETOWN HOYAS* | W 90-79 | 14-16 | T. Freymond 29 | H. Duncan 8 | T. Freymond 9 |
| March 3, 2028 | @ Providence Friars* | L 67-76 | 14-17 | T. Freymond 14 | H. Duncan 4 | E. Samuel 13 |
| March 9, 2028 | @ Seton Hall Pirates (11-19, 8-6 Home) Big East Tournament | - | | | | |
