| November 15, 2027 | TOWSON TIGERS | L 71-81 | 0-1 | D. Strohm 16 | W. Tann 7 | D. Townes 11 |
| November 18, 2027 | SAINT FRANCIS (PA) RED FLASH | W 84-64 | 1-1 | E. Wilcox 19 | W. Tann 5 | D. Strohm 10 |
| November 21, 2027 | DUQUESNE DUKES Hall of Fame Classic | L 85-90 OT | 1-2 | E. Wilcox 21 | W. Tann 7 | E. Wilcox 9 |
| November 25, 2027 | @ San Diego Toreros | L 82-92 | 1-3 | D. Townes 18 | W. Tann 4 | R. Chenowith 6 |
| November 29, 2027 | MONTANA STATE BOBCATS | W 77-52 | 2-3 | E. Wilcox 18 | W. Tann 6 | E. Wilcox 11 |
| December 2, 2027 | HOFSTRA PRIDE | L 68-75 | 2-4 | E. Wilcox 23 | W. Tann 4 | E. Wilcox 11 |
| December 6, 2027 | MEMPHIS TIGERS | W 82-72 | 3-4 | D. Townes 18 | D. Strohm 5 | D. Townes 8 |
| December 13, 2027 | @ Oregon State Beavers | W 78-60 | 4-4 | D. Townes 21 | W. Tann 9 | E. Wilcox 11 |
| December 20, 2027 | NORTHWESTERN WILDCATS (5-3, 0-1 Away) | - | | | | |
| December 26, 2027 | DEPAUL BLUE DEMONS (6-2, 0-0, 1-2 Away)* | - | | | | |
| December 28, 2027 | @ Connecticut Huskies (2-6, 0-0, 1-4 Home)* | - | | | | |
| December 30, 2027 | @ Xavier Musketeers (5-4, 0-0, 2-2 Home)* | - | | | | |
| January 2, 2028 | GEORGETOWN HOYAS (8-0, 0-0, 1-0 Away)* | - | | | | |
| January 4, 2028 | @ Providence Friars (7-3, 0-0, 3-3 Home)* | - | | | | |
| January 6, 2028 | CREIGHTON BLUE JAYS (8-2, 0-0, 0-0 Away)* | - | | | | |
| January 13, 2028 | SETON HALL PIRATES (9-1, 0-0, 1-0 Away)* | - | | | | |
| January 18, 2028 | @ Butler Bulldogs (6-4, 0-0, 2-1 Home)* | - | | | | |
| January 20, 2028 | @ Marquette Golden Eagles (10-1, 0-0, 5-1 Home)* | - | | | | |
| January 27, 2028 | VILLANOVA WILDCATS (7-0, 0-0, 3-0 Away)* | - | | | | |
| February 1, 2028 | PROVIDENCE FRIARS (7-3, 0-0, 1-0 Away)* | - | | | | |
| February 3, 2028 | @ Seton Hall Pirates (9-1, 0-0, 5-1 Home)* | - | | | | |
| February 8, 2028 | MARQUETTE GOLDEN EAGLES (10-1, 0-0, 1-0 Away)* | - | | | | |
| February 10, 2028 | BUTLER BULLDOGS (6-4, 0-0, 1-3 Away)* | - | | | | |
| February 15, 2028 | @ Creighton Blue Jays (8-2, 0-0, 6-1 Home)* | - | | | | |
| February 17, 2028 | @ Villanova Wildcats (7-0, 0-0, 4-0 Home)* | - | | | | |
| February 22, 2028 | @ Georgetown Hoyas (8-0, 0-0, 7-0 Home)* | - | | | | |
| February 24, 2028 | @ DePaul Blue Demons (6-2, 0-0, 5-0 Home)* | - | | | | |
| March 1, 2028 | XAVIER MUSKETEERS (5-4, 0-0, 2-1 Away)* | - | | | | |
| March 3, 2028 | CONNECTICUT HUSKIES (2-6, 0-0, 0-1 Away)* | - | | | | |
