| November 15, 2027 | #16 VILLANOVA WILDCATS | L 79-82 | 0-1 | N. Kennedy 24 | N. Kennedy 5 | J. Wright 6 |
| November 18, 2027 | SOUTH FLORIDA BULLS | W 74-60 | 1-1 | N. Kennedy 22 | C. Jefferson 5 | C. Watson 9 |
| November 20, 2027 | DARTMOUTH BIG GREEN | W 70-60 | 2-1 | C. Watson 16 | C. Jefferson 6 | C. Respert 10 |
| November 22, 2027 | PRINCETON TIGERS | L 85-92 OT | 2-2 | N. Kennedy 24 | C. Jefferson 13 | J. Wright 9 |
| November 25, 2027 | TULSA GOLDEN HURRICANES | W 65-56 | 3-2 | N. Kennedy 24 | C. Jefferson 7 | I. West 9 |
| November 30, 2027 | MARIST RED FOXES | W 79-70 | 4-2 | N. Kennedy 28 | C. Jefferson 5 | C. Watson 9 |
| December 6, 2027 | ARMY BLACK KNIGHTS | W 73-53 | 5-2 | N. Kennedy 28 | R. Rose 6 | C. Respert 7 |
| December 13, 2027 | BUTLER BULLDOGS | L 86-92 | 5-3 | J. Wright 23 | C. Jefferson 7 | C. Watson 9 |
| December 19, 2027 | SO. CAROLINA UPSTATE SPARTANS | W 89-76 | 6-3 | C. Watson 20 | C. Jefferson 12 | C. Watson 12 |
| December 26, 2027 | IOWA HAWKEYES* | W 71-60 | 7-3 | C. Watson 20 | C. Jefferson 6 | J. Wright 9 |
| December 28, 2027 | #18 MARYLAND TERRAPINS* | W 87-85 | 8-3 | N. Kennedy 25 | C. Jefferson 8 | N. Kennedy 6 |
| January 2, 2028 | @ Illinois Fighting Illini* | W 97-85 | 9-3 | N. Kennedy 22 | C. Jefferson 7 | C. Respert 6 |
| January 4, 2028 | @ #3 Michigan Wolverines* | L 57-96 | 9-4 | N. Kennedy 20 | N. Kennedy 3 | C. Watson 9 |
| January 9, 2028 | #22 MICHIGAN STATE SPARTANS* | W 77-69 | 10-4 | C. Watson 22 | C. Jefferson 4 | C. Watson 10 |
| January 11, 2028 | PENN STATE NITTANY LIONS* | W 87-70 | 11-4 | J. Wright 22 | C. Watson 5 | C. Watson 9 |
| January 16, 2028 | @ UCLA Bruins* | L 57-78 | 11-5 | N. Kennedy 18 | C. Jefferson 5 | C. Respert 7 |
| January 18, 2028 | RUTGERS SCARLET KNIGHTS* | W 77-52 | 12-5 | C. Watson 18 | N. Kennedy 5 | C. Watson 10 |
| January 23, 2028 | @ Minnesota Golden Gophers* | L 84-98 OT | 12-6 | N. Kennedy 23 | C. Jefferson 5 | C. Respert 9 |
| January 25, 2028 | @ Northwestern Wildcats* | W 88-70 | 13-6 | N. Kennedy 25 | C. Jefferson 8 | C. Watson 5 |
| January 30, 2028 | @ Oregon Ducks* | L 70-84 | 13-7 | N. Kennedy 24 | C. Jefferson 6 | C. Watson 18 |
| February 1, 2028 | @ Ohio State Buckeyes* | W 89-74 | 14-7 | C. Watson 15 | C. Jefferson 4 | C. Respert 10 |
| February 6, 2028 | INDIANA HOOSIERS* | W 82-59 | 15-7 | C. Watson 17 | C. Jefferson 7 | C. Watson 7 |
| February 8, 2028 | #20 PURDUE BOILERMAKERS* | W 93-84 | 16-7 | N. Kennedy 35 | C. Jefferson 9 | I. West 8 |
| February 13, 2028 | @ Washington Huskies* | W 91-80 | 17-7 | J. Wright 23 | C. Jefferson 6 | S. Allison 7 |
| February 15, 2028 | @ #21 Wisconsin Badgers* | L 64-73 | 17-8 | N. Kennedy 27 | C. Jefferson 6 | C. Watson 9 |
| February 20, 2028 | NEBRASKA CORNHUSKERS* | W 85-65 | 18-8 | N. Kennedy 29 | C. Jefferson 8 | C. Watson 13 |
| February 22, 2028 | #3 MICHIGAN WOLVERINES* | W 86-82 | 19-8 | C. Watson 19 | C. Jefferson 5 | C. Respert 7 |
| February 27, 2028 | @ Iowa Hawkeyes* | W 78-67 | 20-8 | J. Wright 16 | C. Jefferson 4 | C. Watson 13 |
| March 1, 2028 | ILLINOIS FIGHTING ILLINI* | W 80-65 | 21-8 | N. Kennedy 25 | C. Jefferson 4 | C. Watson 13 |
| March 10, 2028 | NEBRASKA CORNHUSKERS Big 10 Tournament | W 88-63 | 22-8 | N. Kennedy 19 | C. Jefferson 10 | C. Watson 8 |
| March 11, 2028 | #11 MARYLAND TERRAPINS Big 10 Tournament | L 70-88 | 22-9 | C. Watson 17 | C. Jefferson 6 | C. Watson 6 |
