| November 14, 2027 | LIBERTY FLAMES | L 73-83 | 0-1 | C. Goode 12 | A. Malone 8 | M. Kent 8 |
| November 17, 2027 | WEST GEORGIA WOLFPACK | W 85-74 | 1-1 | B. Rivera 19 | A. Malone 4 | B. Rivera 12 |
| November 21, 2027 | @ Central Florida Knights Charleston Classic | L 68-84 | 1-2 | M. Kent 23 | A. Malone 6 | B. Rivera 5 |
| November 26, 2027 | STONY BROOK SEAWOLVES | W 78-67 | 2-2 | B. Rivera 15 | B. Rivera 4 | B. Rivera 9 |
| November 30, 2027 | TENNESSEE STATE TIGERS | L 88-90 | 2-3 | B. Rivera 19 | G. Stevens 4 | B. Rivera 8 |
| December 2, 2027 | DUQUESNE DUKES | W 74-68 | 3-3 | A. Malone 16 | M. Kent 4 | M. Kent 10 |
| December 6, 2027 | @ La Salle Explorers | L 86-95 OT | 3-4 | B. Davis 19 | A. Malone 8 | B. Davis 9 |
| December 10, 2027 | NOTRE DAME FIGHTING IRISH | L 69-81 | 3-5 | M. Kent 26 | A. Malone 5 | M. Kent 9 |
| December 14, 2027 | NEW HAVEN CHARGERS | W 81-70 | 4-5 | B. Rivera 21 | C. Goode 4 | B. Rivera 10 |
| December 26, 2027 | @ #25 Michigan Wolverines* | L 68-93 | 4-6 | C. Goode 14 | T. Howe 3 | B. Rivera 11 |
| December 28, 2027 | INDIANA HOOSIERS* | W 76-69 | 5-6 | M. Kent 17 | A. Malone 3 | B. Rivera 9 |
| January 2, 2028 | @ Minnesota Golden Gophers* | L 68-73 | 5-7 | M. Kent 18 | C. Goode 3 | A. Malone 6 |
| January 4, 2028 | PENN STATE NITTANY LIONS* | W 94-82 | 6-7 | T. Howe 20 | C. Goode 6 | M. Kent 10 |
| January 9, 2028 | @ Maryland Terrapins* | L 76-103 | 6-8 | C. Goode 19 | A. Malone 6 | B. Rivera 11 |
| January 11, 2028 | @ #17 Purdue Boilermakers* | L 76-95 | 6-9 | A. Babcock 16 | A. Malone 4 | B. Davis 7 |
| January 16, 2028 | OHIO STATE BUCKEYES* | W 79-61 | 7-9 | B. Davis 15 | C. Goode 4 | B. Davis 10 |
| January 18, 2028 | @ #2 Michigan State Spartans* | L 67-88 | 7-10 | M. Kent 11 | G. Stevens 3 | A. Babcock 7 |
| January 23, 2028 | #5 WISCONSIN BADGERS* | L 84-101 | 7-11 | R. Nee 16 | A. Malone 5 | B. Rivera 4 |
| January 25, 2028 | SOUTHERN CALIFORNIA TROJANS* | W 82-73 | 8-11 | B. Rivera 14 | G. Stevens 6 | B. Rivera 6 |
| January 30, 2028 | #20 OREGON DUCKS* | W 90-79 | 9-11 | B. Rivera 21 | C. Goode 6 | B. Rivera 18 |
| February 1, 2028 | @ UCLA Bruins* | L 67-71 | 9-12 | B. Davis 13 | A. Malone 4 | B. Rivera 12 |
| February 6, 2028 | @ Iowa Hawkeyes* | L 70-82 | 9-13 | M. Kent 12 | A. Malone 5 | B. Rivera 12 |
| February 8, 2028 | WASHINGTON HUSKIES* | L 74-92 | 9-14 | B. Rivera 19 | A. Malone 3 | B. Rivera 10 |
| February 13, 2028 | NORTHWESTERN WILDCATS* | W 103-97 | 10-14 | B. Rivera 32 | G. Stevens 6 | B. Rivera 8 |
| February 15, 2028 | @ Nebraska Cornhuskers* | L 94-109 | 10-15 | M. Kent 23 | A. Malone 7 | A. Babcock 8 |
| February 20, 2028 | @ Illinois Fighting Illini* | W 99-85 | 11-15 | M. Kent 30 | A. Malone 5 | B. Davis 9 |
| February 22, 2028 | ILLINOIS FIGHTING ILLINI* | W 106-100 | 12-15 | T. Howe 23 | A. Babcock 4 | B. Davis 9 |
| February 27, 2028 | @ Southern California Trojans* | W 86-73 | 13-15 | T. Howe 21 | A. Malone 5 | M. Kent 12 |
| March 1, 2028 | UCLA BRUINS* | W 90-77 | 14-15 | A. Babcock 15 | A. Malone 6 | M. Kent 8 |
| March 9, 2028 | @ Oregon Ducks (21-10, 15-3 Home) Big 10 Tournament | - | | | | |
