| November 14, 2027 | @ Army Black Knights | L 75-82 | 0-1 | L. Adams 26 | M. Thornton 6 | M. Driesell 9 |
| November 17, 2027 | @ Citadel Bulldogs | L 71-80 | 0-2 | L. Adams 21 | M. Thornton 5 | V. Xavier 10 |
| November 22, 2027 | @ Southern Mississippi Golden Eagles | W 88-82 | 1-2 | W. Kickert 17 | L. Adams 6 | M. Driesell 7 |
| November 24, 2027 | WESTERN MICHIGAN BRONCOS | W 79-57 | 2-2 | L. Adams 22 | M. Deane 6 | V. Xavier 7 |
| November 28, 2027 | @ Nebraska Cornhuskers | L 75-80 | 2-3 | M. Driesell 19 | L. Adams 5 | V. Xavier 9 |
| December 1, 2027 | @ Kent State Golden Flashes | L 66-74 | 2-4 | L. Adams 16 | M. Thornton 2 | L. Adams 9 |
| December 5, 2027 | @ UC-Riverside Highlanders | L 58-72 | 2-5 | L. Adams 20 | M. Thornton 7 | V. Xavier 10 |
| December 8, 2027 | NJIT HIGHLANDERS | W 92-78 | 3-5 | L. Adams 18 | M. Thornton 6 | M. Driesell 10 |
| December 12, 2027 | @ Lehigh Mountain Hawks | L 74-75 | 3-6 | L. Adams 27 | M. Thornton 6 | M. Deane 9 |
| December 15, 2027 | WRIGHT STATE RAIDERS | W 92-69 | 4-6 | M. Driesell 22 | B. Sarpy 4 | M. Driesell 8 |
| December 19, 2027 | HARVARD CRIMSON | L 81-89 | 4-7 | L. Adams 18 | M. Deane 5 | V. Xavier 11 |
| December 22, 2027 | @ Bryant Bulldogs | L 81-85 | 4-8 | L. Adams 17 | M. Driesell 4 | M. Driesell 12 |
| December 26, 2027 | BELLARMINE KNIGHTS | W 83-76 | 5-8 | M. Thornton 23 | M. Thornton 8 | M. Driesell 9 |
| January 2, 2028 | SO. CAROLINA UPSTATE SPARTANS* | W 66-55 | 6-8 | L. Adams 17 | B. Sarpy 6 | V. Xavier 8 |
| January 5, 2028 | @ High Point Panthers* | W 66-51 | 7-8 | M. Driesell 14 | B. Sarpy 3 | M. Deane 11 |
| January 9, 2028 | NC-ASHEVILLE BULLDOGS* | W 92-67 | 8-8 | B. Sarpy 17 | M. Driesell 5 | M. Driesell 7 |
| January 12, 2028 | @ Longwood Lancers* | L 76-90 | 8-9 | L. Adams 16 | L. Adams 5 | V. Xavier 8 |
| January 16, 2028 | GARDNER-WEBB RUNNIN' BULLDOGS* | W 81-62 | 9-9 | L. Adams 18 | L. Adams 4 | W. Kickert 9 |
| January 23, 2028 | @ Winthrop Eagles* | L 74-75 | 9-10 | V. Xavier 12 | B. Sarpy 7 | V. Xavier 13 |
| January 26, 2028 | CHARLESTON SOUTHERN BUCCANEERS* | W 63-55 | 10-10 | L. Adams 27 | M. Driesell 4 | M. Deane 10 |
| January 30, 2028 | @ Presbyterian Blue Hose* | W 77-59 | 11-10 | L. Adams 18 | M. Thornton 4 | V. Xavier 14 |
| February 2, 2028 | @ So. Carolina Upstate Spartans* | L 65-73 | 11-11 | L. Adams 11 | L. Adams 4 | M. Driesell 7 |
| February 6, 2028 | HIGH POINT PANTHERS* | W 77-64 | 12-11 | L. Adams 20 | M. Thornton 10 | M. Deane 12 |
| February 9, 2028 | @ NC-Asheville Bulldogs* | W 89-84 | 13-11 | L. Adams 20 | L. Adams 5 | V. Xavier 8 |
| February 13, 2028 | LONGWOOD LANCERS* | L 82-86 | 13-12 | L. Adams 27 | M. Thornton 8 | V. Xavier 8 |
| February 16, 2028 | @ Gardner-Webb Runnin' Bulldogs* | L 62-82 | 13-13 | M. Driesell 18 | M. Thornton 4 | M. Driesell 12 |
| February 23, 2028 | WINTHROP EAGLES* | W 75-66 | 14-13 | M. Thornton 24 | M. Thornton 5 | V. Xavier 13 |
| February 27, 2028 | @ Charleston Southern Buccaneers* | W 89-79 | 15-13 | L. Adams 24 | M. Thornton 6 | L. Adams 7 |
| March 2, 2028 | PRESBYTERIAN BLUE HOSE* | W 75-65 | 16-13 | V. Xavier 22 | M. Deane 6 | V. Xavier 15 |
| March 6, 2028 | NC-ASHEVILLE BULLDOGS Big South Tournament | W 67-61 | 17-13 | W. Kickert 19 | L. Adams 4 | M. Driesell 8 |
| March 7, 2028 | LONGWOOD LANCERS Big South Tournament | W 74-64 | 18-13 | M. Thornton 19 | B. Sarpy 3 | L. Adams 6 |
| March 8, 2028 | SO. CAROLINA UPSTATE SPARTANS Big South Tournament | L 67-89 | 18-14 | V. Xavier 18 | L. Adams 4 | M. Driesell 8 |
