| November 15, 2027 | @ Illinois Fighting Illini | L 66-83 | 0-1 | C. Xavier 22 | C. Xavier 5 | M. Chavis 7 |
| November 19, 2027 | @ Pacific Tigers | L 63-81 | 0-2 | R. Claxton 17 | D. Randolph 3 | J. Jenkins 7 |
| November 21, 2027 | @ Alabama A&M Bulldogs | L 70-83 | 0-3 | C. Xavier 20 | D. Randolph 7 | N. Lofton 7 |
| November 30, 2027 | SANTA CLARA BRONCOS | W 105-83 | 1-3 | C. Xavier 23 | R. Claxton 6 | M. Chavis 7 |
| December 3, 2027 | @ Lehigh Mountain Hawks | L 72-85 | 1-4 | N. Lofton 18 | J. Jenkins 4 | J. Jenkins 8 |
| December 7, 2027 | JACKSONVILLE STATE GAMECOCKS | W 79-72 | 2-4 | C. Xavier 24 | D. Randolph 5 | J. Jenkins 7 |
| December 10, 2027 | DRAKE BULLDOGS | W 91-65 | 3-4 | D. Randolph 20 | R. Claxton 6 | M. Chavis 11 |
| December 12, 2027 | LITTLE ROCK TROJANS | W 87-78 | 4-4 | C. Xavier 29 | M. Chavis 5 | M. Chavis 7 |
| December 16, 2027 | ST. THOMAS TOMMIES | W 84-71 | 5-4 | D. Randolph 19 | J. Jenkins 5 | J. Jenkins 10 |
| December 19, 2027 | NORTHERN KENTUCKY NORSE (2-6, 1-3 Away) | - | | | | |
| December 24, 2027 | @ Elon Phoenix (2-7, 1-1 Home) | - | | | | |
| December 28, 2027 | ERIE FREIGHTERS (4-5, 0-5 Away) | - | | | | |
| December 31, 2027 | ALBANY GREAT DANES (2-8, 0-7 Away) | - | | | | |
| January 7, 2028 | @ Jacksonville Dolphins (3-7, 0-0, 3-1 Home)* | - | | | | |
| January 11, 2028 | AUSTIN PEAY GOVERNORS (2-8, 0-0, 1-6 Away)* | - | | | | |
| January 14, 2028 | @ West Georgia Wolfpack (3-7, 0-0, 2-1 Home)* | - | | | | |
| January 18, 2028 | EASTERN KENTUCKY COLONELS (5-5, 0-0, 2-4 Away)* | - | | | | |
| January 21, 2028 | LIPSCOMB BISONS (4-6, 0-0, 2-3 Away)* | - | | | | |
| January 25, 2028 | NORTH ALABAMA LIONS (2-8, 0-0, 0-5 Away)* | - | | | | |
| January 28, 2028 | BELLARMINE KNIGHTS (5-5, 0-0, 1-5 Away)* | - | | | | |
| February 1, 2028 | @ Florida Gulf Coast Eagles (4-6, 0-0, 3-3 Home)* | - | | | | |
| February 4, 2028 | STETSON HATTERS (7-3, 0-0, 5-2 Away)* | - | | | | |
| February 8, 2028 | @ Central Arkansas Bears (3-7, 0-0, 1-3 Home)* | - | | | | |
| February 11, 2028 | @ North Florida Osprey (4-6, 0-0, 3-1 Home)* | - | | | | |
| February 15, 2028 | JACKSONVILLE DOLPHINS (3-7, 0-0, 0-6 Away)* | - | | | | |
| February 18, 2028 | @ Austin Peay Governors (2-8, 0-0, 1-2 Home)* | - | | | | |
| February 22, 2028 | WEST GEORGIA WOLFPACK (3-7, 0-0, 1-6 Away)* | - | | | | |
| February 25, 2028 | @ Eastern Kentucky Colonels (5-5, 0-0, 3-1 Home)* | - | | | | |
| March 4, 2028 | @ Lipscomb Bisons (4-6, 0-0, 2-3 Home)* | - | | | | |
