| November 15, 2027 | @ Illinois Fighting Illini | L 66-83 | 0-1 | C. Xavier 22 | C. Xavier 5 | M. Chavis 7 |
| November 19, 2027 | @ Pacific Tigers | L 63-81 | 0-2 | R. Claxton 17 | D. Randolph 3 | J. Jenkins 7 |
| November 21, 2027 | @ Alabama A&M Bulldogs | L 70-83 | 0-3 | C. Xavier 20 | D. Randolph 7 | N. Lofton 7 |
| November 30, 2027 | SANTA CLARA BRONCOS | W 105-83 | 1-3 | C. Xavier 23 | R. Claxton 6 | M. Chavis 7 |
| December 3, 2027 | @ Lehigh Mountain Hawks | L 72-85 | 1-4 | N. Lofton 18 | J. Jenkins 4 | J. Jenkins 8 |
| December 7, 2027 | JACKSONVILLE STATE GAMECOCKS | W 79-72 | 2-4 | C. Xavier 24 | D. Randolph 5 | J. Jenkins 7 |
| December 10, 2027 | DRAKE BULLDOGS | W 91-65 | 3-4 | D. Randolph 20 | R. Claxton 6 | M. Chavis 11 |
| December 12, 2027 | LITTLE ROCK TROJANS | W 87-78 | 4-4 | C. Xavier 29 | M. Chavis 5 | M. Chavis 7 |
| December 16, 2027 | ST. THOMAS TOMMIES | W 84-71 | 5-4 | D. Randolph 19 | J. Jenkins 5 | J. Jenkins 10 |
| December 19, 2027 | NORTHERN KENTUCKY NORSE | L 84-94 | 5-5 | M. Chavis 15 | C. Xavier 5 | M. Chavis 7 |
| December 24, 2027 | @ Elon Phoenix | W 94-91 OT | 6-5 | C. Xavier 21 | D. Randolph 5 | D. Freeman 9 |
| December 28, 2027 | ERIE FREIGHTERS | W 81-76 | 7-5 | C. Xavier 16 | D. Randolph 4 | M. Chavis 5 |
| December 31, 2027 | ALBANY GREAT DANES | L 74-87 | 7-6 | C. Xavier 18 | D. Randolph 6 | M. Chavis 6 |
| January 7, 2028 | @ Jacksonville Dolphins* | L 75-88 | 7-7 | R. Claxton 17 | M. Chavis 3 | J. Jenkins 8 |
| January 11, 2028 | AUSTIN PEAY GOVERNORS* | W 82-56 | 8-7 | C. Xavier 17 | D. Randolph 5 | M. Chavis 6 |
| January 14, 2028 | @ West Georgia Wolfpack* | W 85-72 | 9-7 | M. Chavis 17 | D. Randolph 3 | J. Jenkins 8 |
| January 18, 2028 | EASTERN KENTUCKY COLONELS* | W 92-74 | 10-7 | D. Randolph 22 | D. Randolph 7 | D. Freeman 7 |
| January 21, 2028 | LIPSCOMB BISONS* | L 78-92 | 10-8 | R. Claxton 16 | D. Randolph 4 | M. Chavis 6 |
| January 25, 2028 | NORTH ALABAMA LIONS* | W 86-68 | 11-8 | D. Randolph 17 | D. Randolph 3 | N. Lofton 8 |
| January 28, 2028 | BELLARMINE KNIGHTS* | L 76-84 | 11-9 | C. Xavier 22 | D. Randolph 6 | J. Jenkins 8 |
| February 1, 2028 | @ Florida Gulf Coast Eagles* | W 80-77 | 12-9 | D. Randolph 24 | R. Claxton 4 | J. Jenkins 7 |
| February 4, 2028 | STETSON HATTERS* | L 84-94 OT | 12-10 | M. Chavis 19 | D. Randolph 5 | M. Chavis 7 |
| February 8, 2028 | @ Central Arkansas Bears* | L 57-71 | 12-11 | M. Chavis 11 | J. Havens 3 | J. Jenkins 10 |
| February 11, 2028 | @ North Florida Osprey* | L 86-96 | 12-12 | C. Xavier 19 | D. Randolph 9 | D. Freeman 5 |
| February 15, 2028 | JACKSONVILLE DOLPHINS* | L 74-85 | 12-13 | C. Xavier 17 | D. Randolph 3 | M. Chavis 9 |
| February 18, 2028 | @ Austin Peay Governors* | W 77-59 | 13-13 | C. Xavier 20 | J. Jenkins 5 | J. Jenkins 7 |
| February 22, 2028 | WEST GEORGIA WOLFPACK* | L 82-84 | 13-14 | R. Claxton 15 | C. Xavier 5 | D. Freeman 6 |
| February 25, 2028 | @ Eastern Kentucky Colonels* | L 84-86 | 13-15 | C. Xavier 24 | D. Randolph 3 | M. Chavis 8 |
| March 4, 2028 | @ Lipscomb Bisons* | L 89-92 | 13-16 | C. Xavier 21 | D. Randolph 8 | J. Havens 4 |
| March 5, 2028 | @ Lipscomb Bisons A-Sun Tournament | L 84-85 | 13-17 | M. Chavis 17 | R. Claxton 6 | R. Hunter 6 |
