| November 16, 2027 | EVANSVILLE PURPLE ACES | W 71-69 | 1-0 | M. Bailey 21 | C. Duncan 6 | M. Bailey 9 |
| November 19, 2027 | CHATTANOOGA MOCS | W 75-72 | 2-0 | K. Stewart 13 | C. Duncan 5 | M. Bailey 7 |
| November 23, 2027 | LOUISIANA-MONROE WARHAWKS | L 69-77 | 2-1 | M. Bailey 21 | C. Duncan 8 | N. Brinker 7 |
| November 30, 2027 | VMI KEYDETS | L 72-81 | 2-2 | K. Stewart 16 | E. Nolan 4 | K. Stewart 8 |
| December 2, 2027 | GARDNER-WEBB RUNNIN' BULLDOGS | L 77-91 | 2-3 | M. Bailey 15 | C. Duncan 3 | N. Brinker 5 |
| December 7, 2027 | @ Arizona Wildcats | L 74-93 | 2-4 | C. Duncan 15 | C. Duncan 2 | E. Nolan 5 |
| December 10, 2027 | @ Stanford Cardinal | L 64-75 | 2-5 | P. Welch 15 | N. Brinker 4 | P. Welch 7 |
| December 14, 2027 | LONG ISLAND SHARKS | W 97-73 | 3-5 | P. Welch 18 | N. Brinker 4 | K. Stewart 5 |
| December 21, 2027 | WESTERN ILLINOIS LEATHERNECKS | W 58-48 | 4-5 | E. Nolan 12 | C. Duncan 4 | P. Welch 6 |
| December 26, 2027 | @ Northwestern Wildcats* | W 77-65 | 5-5 | M. Bailey 15 | C. Duncan 4 | S. Pack 7 |
| December 28, 2027 | @ UCLA Bruins* | L 64-82 | 5-6 | N. Brinker 17 | C. Duncan 7 | M. Bailey 6 |
| January 2, 2028 | #2 MICHIGAN STATE SPARTANS* | L 60-77 | 5-7 | P. Welch 15 | C. Duncan 4 | N. Brinker 6 |
| January 4, 2028 | @ Rutgers Scarlet Knights* | L 82-94 | 5-8 | P. Welch 18 | C. Duncan 4 | S. Pack 5 |
| January 9, 2028 | SOUTHERN CALIFORNIA TROJANS* | L 73-78 | 5-9 | S. Pack 14 | E. Nolan 4 | M. Bailey 8 |
| January 11, 2028 | @ Washington Huskies* | W 86-79 | 6-9 | P. Welch 23 | C. Duncan 6 | M. Bailey 11 |
| January 16, 2028 | #14 OREGON DUCKS* | L 75-95 | 6-10 | P. Welch 13 | C. Duncan 3 | M. Bailey 8 |
| January 18, 2028 | @ #15 Purdue Boilermakers* | W 72-65 | 7-10 | S. Pack 13 | E. Nolan 6 | P. Welch 5 |
| January 23, 2028 | MINNESOTA GOLDEN GOPHERS* | L 73-84 | 7-11 | P. Welch 20 | E. Nolan 4 | M. Bailey 7 |
| January 25, 2028 | MICHIGAN WOLVERINES* | W 76-65 | 8-11 | N. Brinker 15 | E. Nolan 7 | M. Bailey 8 |
| January 30, 2028 | @ Illinois Fighting Illini* | L 74-76 | 8-12 | P. Welch 14 | P. Welch 3 | M. Bailey 8 |
| February 1, 2028 | NEBRASKA CORNHUSKERS* | W 80-69 | 9-12 | P. Welch 18 | C. Duncan 5 | K. Stewart 8 |
| February 6, 2028 | MARYLAND TERRAPINS* | W 80-76 | 10-12 | P. Welch 16 | C. Duncan 5 | S. Pack 8 |
| February 8, 2028 | @ Iowa Hawkeyes* | L 68-87 | 10-13 | P. Welch 10 | C. Duncan 2 | N. Brinker 9 |
| February 13, 2028 | INDIANA HOOSIERS* | W 78-48 | 11-13 | P. Welch 15 | C. Duncan 5 | N. Brinker 9 |
| February 15, 2028 | @ Ohio State Buckeyes* | L 65-78 | 11-14 | P. Welch 19 | C. Duncan 5 | P. Welch 5 |
| February 20, 2028 | #3 WISCONSIN BADGERS* | L 54-89 | 11-15 | P. Havens 14 | S. Pack 2 | K. Stewart 3 |
| February 22, 2028 | IOWA HAWKEYES* | W 103-95 | 12-15 | P. Welch 18 | P. Welch 5 | M. Bailey 7 |
| February 27, 2028 | @ Indiana Hoosiers* | L 60-72 | 12-16 | C. Duncan 11 | C. Duncan 5 | M. Bailey 8 |
| March 1, 2028 | @ #4 Michigan State Spartans* | L 72-84 | 12-17 | M. Bailey 14 | C. Duncan 3 | M. Bailey 6 |
| March 8, 2028 | NEBRASKA CORNHUSKERS (15-15, 3-9 Away) Big 10 Tournament | - | | | | |
