| November 15, 2027 | JACKSON STATE TIGERS | W 77-76 | 1-0 | C. Shepard 24 | R. Blossom 5 | C. Shepard 11 |
| November 18, 2027 | FAIRLEIGH DICKINSON KNIGHTS | W 92-73 | 2-0 | C. Shepard 29 | R. Sharpe 6 | C. Shepard 18 |
| November 22, 2027 | PRAIRIE VIEW PANTHERS | W 62-55 | 3-0 | C. Shepard 14 | R. Blossom 7 | C. Shepard 16 |
| November 25, 2027 | @ Kansas State Wildcats Myrtle Beach Invitational | W 73-64 | 4-0 | C. Shepard 24 | R. Blossom 5 | C. Shepard 10 |
| November 26, 2027 | @ Notre Dame Fighting Irish Myrtle Beach Invitational | W 84-76 | 5-0 | R. Sharpe 20 | R. Blossom 6 | C. Shepard 9 |
| November 27, 2027 | @ #14 VA Commonwealth Rams Myrtle Beach Invitational | W 90-54 | 6-0 | R. Sharpe 21 | R. Sharpe 4 | C. Shepard 9 |
| November 29, 2027 | #6 WEST VIRGINIA MOUNTAINEERS | L 67-84 | 6-1 | R. Sharpe 16 | R. Sharpe 2 | C. Shepard 12 |
| December 2, 2027 | #4 VIRGINIA CAVALIERS | L 60-86 | 6-2 | M. Woods 16 | R. Sharpe 4 | R. Sharpe 6 |
| December 6, 2027 | LOUISIANA-MONROE WARHAWKS | L 75-80 | 6-3 | R. Blossom 18 | R. Blossom 8 | C. Shepard 16 |
| December 13, 2027 | @ Rhode Island Rams | W 84-72 | 7-3 | R. Sharpe 24 | R. Sharpe 9 | I. Goode 9 |
| December 20, 2027 | GEORGIA TECH YELLOW JACKETS | W 65-58 | 8-3 | R. Blossom 18 | R. Blossom 5 | C. Shepard 8 |
| December 26, 2027 | @ Butler Bulldogs* | L 60-71 | 8-4 | C. Shepard 13 | R. Blossom 6 | C. Shepard 9 |
| December 28, 2027 | #16 CREIGHTON BLUE JAYS* | W 49-47 | 9-4 | C. Shepard 12 | R. Blossom 3 | C. Shepard 11 |
| January 2, 2028 | @ #2 Marquette Golden Eagles* | L 74-95 | 9-5 | R. Sharpe 22 | R. Blossom 9 | R. Sharpe 4 |
| January 4, 2028 | ST. JOHNS RED STORM* | W 75-74 | 10-5 | C. Shepard 22 | R. Blossom 5 | C. Shepard 16 |
| January 11, 2028 | SETON HALL PIRATES* | W 69-64 | 11-5 | R. Sharpe 16 | R. Blossom 5 | G. Howell 6 |
| January 13, 2028 | @ #19 Villanova Wildcats* | L 68-76 | 11-6 | R. Sharpe 12 | R. Blossom 8 | C. Shepard 8 |
| January 20, 2028 | CONNECTICUT HUSKIES* | L 70-73 | 11-7 | C. Shepard 22 | R. Blossom 7 | C. Shepard 7 |
| January 23, 2028 | XAVIER MUSKETEERS* | W 71-59 | 12-7 | C. Shepard 21 | R. Blossom 6 | C. Shepard 12 |
| January 27, 2028 | @ DePaul Blue Demons* | L 63-73 | 12-8 | C. Shepard 17 | I. Goode 3 | C. Shepard 13 |
| January 30, 2028 | @ Georgetown Hoyas* | L 76-79 | 12-9 | C. Shepard 31 | R. Blossom 7 | C. Shepard 11 |
| February 1, 2028 | @ St. Johns Red Storm* | L 73-75 OT | 12-10 | C. Shepard 18 | R. Robisch 3 | C. Shepard 15 |
| February 3, 2028 | #22 VILLANOVA WILDCATS* | W 91-66 | 13-10 | M. Woods 28 | R. Blossom 8 | C. Shepard 10 |
| February 8, 2028 | @ Seton Hall Pirates* | W 65-51 | 14-10 | R. Sharpe 16 | R. Blossom 6 | C. Shepard 16 |
| February 13, 2028 | @ Creighton Blue Jays* | W 90-70 | 15-10 | R. Sharpe 21 | R. Sharpe 5 | C. Shepard 18 |
| February 15, 2028 | DEPAUL BLUE DEMONS* | W 99-93 OT | 16-10 | G. Howell 21 | R. Blossom 4 | C. Shepard 12 |
| February 17, 2028 | GEORGETOWN HOYAS* | W 75-54 | 17-10 | C. Shepard 23 | R. Blossom 4 | C. Shepard 11 |
| February 22, 2028 | @ Connecticut Huskies* | W 63-57 | 18-10 | R. Blossom 18 | R. Blossom 4 | C. Shepard 13 |
| February 24, 2028 | @ Xavier Musketeers* | L 48-68 | 18-11 | R. Sharpe 12 | R. Blossom 3 | C. Shepard 7 |
| March 1, 2028 | #23 BUTLER BULLDOGS* | W 86-80 | 19-11 | R. Sharpe 22 | C. Shepard 4 | I. Goode 5 |
| March 3, 2028 | #1 MARQUETTE GOLDEN EAGLES* | L 71-77 | 19-12 | G. Howell 15 | R. Mann 5 | C. Shepard 7 |
| March 10, 2028 | CREIGHTON BLUE JAYS Big East Tournament | W 72-64 | 20-12 | R. Blossom 19 | R. Blossom 3 | C. Shepard 18 |
| March 11, 2028 | @ Xavier Musketeers Big East Tournament | W 69-58 | 21-12 | I. Goode 17 | R. Blossom 8 | C. Shepard 10 |
| March 12, 2028 | @ #1 Marquette Golden Eagles Big East Tournament | L 58-78 | 21-13 | C. Shepard 13 | R. Sharpe 5 | C. Shepard 14 |
