| November 14, 2027 | NC-WILMINGTON SEAHAWKS | W 76-58 | 1-0 | B. Rein 20 | C. Tackett 4 | B. Rein 15 |
| November 17, 2027 | NORTH ALABAMA LIONS | W 60-50 | 2-0 | D. Andersen 16 | T. Kernan 6 | D. Bishop 10 |
| November 21, 2027 | @ Wichita State Shockers | L 57-81 | 2-1 | D. Bishop 14 | B. Rein 2 | J. Robinson 7 |
| November 24, 2027 | ROBERT MORRIS COLONIALS | W 92-65 | 3-1 | J. Robinson 16 | J. Robinson 5 | J. Robinson 7 |
| November 28, 2027 | @ Tennessee Volunteers | L 52-70 | 3-2 | J. Robinson 11 | T. Kernan 3 | H. Riddick 6 |
| December 5, 2027 | OLD DOMINION MONARCHS | L 63-66 OT | 3-3 | B. Rein 14 | D. Vidoni 4 | D. Bishop 18 |
| December 9, 2027 | CHATTANOOGA MOCS Cayman Islands Classic | W 86-62 | 4-3 | J. Robinson 17 | T. Kernan 5 | D. Bishop 9 |
| December 10, 2027 | EASTERN KENTUCKY COLONELS Cayman Islands Classic | W 83-74 | 5-3 | B. Rein 14 | D. Vidoni 5 | D. Bishop 9 |
| December 11, 2027 | @ Tulsa Golden Hurricanes Cayman Islands Classic | W 93-81 OT | 6-3 | J. Robinson 21 | H. Riddick 4 | D. Bishop 12 |
| December 12, 2027 | #25 GEORGIA BULLDOGS | W 70-57 | 7-3 | D. Vidoni 16 | T. Kernan 4 | J. Robinson 8 |
| December 19, 2027 | NC-GREENSBORO SPARTANS | W 79-66 | 8-3 | B. Rein 16 | D. Vidoni 4 | D. Bishop 11 |
| December 26, 2027 | #16 HOUSTON COUGARS* | L 68-82 | 8-4 | J. Robinson 18 | T. Kernan 5 | D. Bishop 10 |
| December 30, 2027 | @ #3 Brigham Young Cougars* | L 69-81 | 8-5 | J. Robinson 12 | C. Tackett 4 | D. Bishop 7 |
| January 4, 2028 | @ Colorado Buffaloes* | W 65-62 | 9-5 | J. Robinson 11 | T. Kernan 4 | D. Bishop 9 |
| January 9, 2028 | CENTRAL FLORIDA KNIGHTS* | W 69-47 | 10-5 | J. Robinson 20 | T. Kernan 8 | D. Bishop 12 |
| January 11, 2028 | KANSAS STATE WILDCATS* | L 85-90 | 10-6 | D. Vidoni 17 | T. Kernan 10 | B. Rein 8 |
| January 13, 2028 | @ Texas Tech Red Raiders* | L 60-66 | 10-7 | D. Bishop 19 | T. Kernan 4 | D. Bishop 7 |
| January 18, 2028 | WEST VIRGINIA MOUNTAINEERS* | W 74-55 | 11-7 | D. Vidoni 14 | D. Vidoni 4 | D. Bishop 12 |
| January 20, 2028 | @ #21 Arizona Wildcats* | W 74-68 | 12-7 | D. Vidoni 20 | T. Kernan 5 | J. Robinson 6 |
| January 25, 2028 | #4 BRIGHAM YOUNG COUGARS* | L 81-93 | 12-8 | D. Bishop 12 | J. Robinson 3 | D. Bishop 8 |
| January 30, 2028 | @ #3 Kansas Jayhawks* | L 66-76 | 12-9 | B. Rein 12 | T. Kernan 5 | D. Bishop 7 |
| February 1, 2028 | @ Utah Utes* | W 67-60 | 13-9 | J. Robinson 17 | T. Kernan 4 | D. Bishop 11 |
| February 3, 2028 | TEXAS CHRISTIAN HORNED FROGS* | W 99-79 | 14-9 | D. Bishop 20 | C. Tackett 4 | J. Robinson 8 |
| February 8, 2028 | @ Cincinnati Bearcats* | L 58-83 | 14-10 | D. Vidoni 10 | T. Kernan 3 | D. Bishop 5 |
| February 10, 2028 | COLORADO BUFFALOES* | W 77-76 | 15-10 | B. Rein 14 | J. Robinson 6 | D. Bishop 8 |
| February 15, 2028 | @ Houston Cougars* | W 80-76 OT | 16-10 | D. Bishop 21 | D. Vidoni 3 | D. Bishop 17 |
| February 17, 2028 | BAYLOR BEARS* | L 78-91 | 16-11 | C. Tackett 16 | C. Tackett 4 | J. Robinson 6 |
| February 20, 2028 | CINCINNATI BEARCATS* | L 82-89 | 16-12 | B. Rein 17 | T. Kernan 7 | J. Robinson 6 |
| February 27, 2028 | @ #12 Iowa State Cyclones* | L 70-89 | 16-13 | D. Bishop 12 | D. Bishop 4 | D. Bishop 9 |
| March 1, 2028 | @ Arizona State Sun Devils* | L 65-79 | 16-14 | D. Vidoni 14 | T. Kernan 8 | D. Bishop 7 |
| March 3, 2028 | #6 KANSAS JAYHAWKS* | L 93-97 | 16-15 | D. Vidoni 15 | T. Kernan 11 | B. Ramsey 7 |
| March 8, 2028 | COLORADO BUFFALOES (9-20, 2-10 Away) Big 12 Tournament | - | | | | |
