| November 14, 2027 | @ Southern Methodist Mustangs | L 66-86 | 0-1 | D. Chapman 15 | J. Cobb 4 | D. Chapman 9 |
| November 18, 2027 | @ #7 Louisville Cardinals | L 63-80 | 0-2 | J. Cobb 12 | J. Chatman 7 | E. Hancock 7 |
| November 21, 2027 | @ Missouri Tigers WSSN Classic | L 59-71 | 0-3 | J. Best 14 | J. Chatman 3 | J. Cobb 10 |
| November 24, 2027 | @ Grambling Tigers | W 87-76 | 1-3 | J. Chatman 22 | J. Chatman 8 | J. Best 7 |
| November 29, 2027 | @ Florida State Seminoles | L 68-74 | 1-4 | J. Chatman 13 | J. Chatman 6 | D. Chapman 9 |
| December 1, 2027 | @ California Baptist Lancers | W 85-77 | 2-4 | J. Chatman 18 | J. Cobb 6 | D. Lofton 6 |
| December 5, 2027 | MASSACHUSETTS MINUTEMEN | W 84-72 | 3-4 | E. Hancock 22 | J. Chatman 8 | E. Hancock 10 |
| December 8, 2027 | ORAL ROBERTS GOLDEN EAGLES | W 72-51 | 4-4 | E. Hancock 16 | J. Chatman 5 | E. Hancock 9 |
| December 21, 2027 | SIENA SAINTS (0-7, 0-4 Away) | - | | | | |
| December 26, 2027 | @ Akron Zips (5-2, 0-0, 5-0 Home)* | - | | | | |
| December 29, 2027 | @ Western Michigan Broncos (2-6, 0-0, 2-0 Home)* | - | | | | |
| January 2, 2028 | EASTERN MICHIGAN EAGLES (5-3, 0-0, 2-3 Away)* | - | | | | |
| January 5, 2028 | NORTHERN ILLINOIS HUSKIES (5-2, 0-0, 2-2 Away)* | - | | | | |
| January 9, 2028 | MIAMI (OH) REDHAWKS (4-4, 0-0, 2-4 Away)* | - | | | | |
| January 12, 2028 | @ Buffalo Bulls (1-7, 0-0, 0-1 Home)* | - | | | | |
| January 16, 2028 | @ Central Michigan Chippewas (4-4, 0-0, 2-0 Home)* | - | | | | |
| January 19, 2028 | TOLEDO ROCKETS (5-4, 0-0, 3-3 Away)* | - | | | | |
| January 23, 2028 | KENT STATE GOLDEN FLASHES (6-3, 0-0, 0-2 Away)* | - | | | | |
| January 26, 2028 | @ Ball State Cardinals (2-5, 0-0, 1-1 Home)* | - | | | | |
| January 30, 2028 | @ Toledo Rockets (5-4, 0-0, 1-0 Home)* | - | | | | |
| February 2, 2028 | @ Kent State Golden Flashes (6-3, 0-0, 5-0 Home)* | - | | | | |
| February 6, 2028 | BUFFALO BULLS (1-7, 0-0, 1-5 Away)* | - | | | | |
| February 9, 2028 | CENTRAL MICHIGAN CHIPPEWAS (4-4, 0-0, 2-4 Away)* | - | | | | |
| February 13, 2028 | @ Eastern Michigan Eagles (5-3, 0-0, 3-0 Home)* | - | | | | |
| February 16, 2028 | @ Northern Illinois Huskies (5-2, 0-0, 3-0 Home)* | - | | | | |
| February 20, 2028 | AKRON ZIPS (5-2, 0-0, 0-1 Away)* | - | | | | |
| February 23, 2028 | WESTERN MICHIGAN BRONCOS (2-6, 0-0, 0-5 Away)* | - | | | | |
| February 27, 2028 | BALL STATE CARDINALS (2-5, 0-0, 1-4 Away)* | - | | | | |
| March 2, 2028 | @ Bowling Green State Falcons (4-4, 0-0, 3-0 Home)* | - | | | | |
