| November 15, 2027 | CANISIUS GOLDEN GRIFFINS | W 80-72 OT | 1-0 | W. Hancock 38 | D. Lee 10 | W. Hancock 15 |
| November 22, 2027 | MARIST RED FOXES | W 60-53 | 2-0 | N. Hancock 15 | D. Lee 4 | W. Hancock 10 |
| November 25, 2027 | BOSTON COLLEGE EAGLES ESPN Events Invitational | L 57-71 | 2-1 | W. Hancock 14 | D. Lee 3 | J. Weathers 6 |
| November 29, 2027 | CALIFORNIA BAPTIST LANCERS | W 82-70 | 3-1 | W. Hancock 21 | D. Lee 5 | W. Hancock 7 |
| December 2, 2027 | XAVIER MUSKETEERS | L 46-73 | 3-2 | D. Lee 10 | D. Lee 5 | W. Hancock 10 |
| December 6, 2027 | @ Houston Cougars | L 48-69 | 3-3 | W. Hancock 15 | D. Lee 2 | C. Dotson 8 |
| December 8, 2027 | DAYTON FLYERS | W 84-69 | 4-3 | D. Lee 19 | D. Lee 3 | J. Weathers 9 |
| December 16, 2027 | SAINT FRANCIS (PA) RED FLASH | W 77-55 | 5-3 | W. Hancock 15 | N. Hancock 4 | W. Hancock 9 |
| December 20, 2027 | @ St. Johns Red Storm | L 76-79 OT | 5-4 | W. Hancock 23 | C. Dotson 4 | J. Weathers 13 |
| December 26, 2027 | #18 MARYLAND TERRAPINS* | L 57-75 | 5-5 | W. Hancock 12 | D. Lee 5 | N. Hancock 5 |
| December 28, 2027 | ILLINOIS FIGHTING ILLINI* | L 59-75 | 5-6 | N. Hancock 18 | D. Lee 8 | C. Dotson 8 |
| January 2, 2028 | IOWA HAWKEYES* | L 66-67 | 5-7 | W. Hancock 25 | D. Lee 7 | J. Weathers 10 |
| January 4, 2028 | #19 WISCONSIN BADGERS* | W 74-67 | 6-7 | N. Hancock 25 | D. Lee 8 | J. Weathers 7 |
| January 9, 2028 | @ Purdue Boilermakers* | L 51-60 | 6-8 | W. Hancock 15 | N. Hancock 3 | W. Hancock 11 |
| January 11, 2028 | #3 MICHIGAN WOLVERINES* | L 59-89 | 6-9 | W. Hancock 20 | D. Lee 5 | W. Hancock 9 |
| January 16, 2028 | @ Washington Huskies* | L 63-83 | 6-10 | N. Hancock 14 | D. Fife 5 | J. Weathers 11 |
| January 18, 2028 | @ Indiana Hoosiers* | L 58-69 | 6-11 | C. Dotson 16 | J. Weathers 6 | J. Weathers 11 |
| January 23, 2028 | OREGON DUCKS* | W 80-69 | 7-11 | W. Hancock 26 | D. Fife 7 | J. Weathers 10 |
| January 25, 2028 | SOUTHERN CALIFORNIA TROJANS* | L 70-88 | 7-12 | W. Hancock 16 | D. Lee 7 | W. Hancock 6 |
| January 30, 2028 | @ UCLA Bruins* | W 59-52 | 8-12 | N. Hancock 25 | W. Hancock 6 | W. Hancock 7 |
| February 1, 2028 | RUTGERS SCARLET KNIGHTS* | W 76-62 | 9-12 | N. Hancock 21 | D. Lee 7 | C. Dotson 7 |
| February 6, 2028 | @ Minnesota Golden Gophers* | W 67-61 | 10-12 | N. Hancock 17 | D. Lee 6 | W. Hancock 8 |
| February 8, 2028 | @ Ohio State Buckeyes* | L 65-86 | 10-13 | W. Hancock 19 | D. Lee 6 | W. Hancock 5 |
| February 13, 2028 | @ Nebraska Cornhuskers* | L 57-78 | 10-14 | W. Hancock 14 | N. Hancock 2 | W. Hancock 11 |
| February 15, 2028 | PENN STATE NITTANY LIONS* | W 63-56 | 11-14 | N. Hancock 15 | D. Lee 5 | J. Weathers 13 |
| February 20, 2028 | @ #21 Michigan State Spartans* | W 61-46 | 12-14 | C. Dotson 15 | D. Lee 3 | J. Weathers 13 |
| February 22, 2028 | OHIO STATE BUCKEYES* | L 49-64 | 12-15 | C. Dotson 15 | D. Lee 4 | C. Dotson 9 |
| February 27, 2028 | @ #3 Michigan Wolverines* | L 46-78 | 12-16 | W. Hancock 14 | D. Fife 2 | J. Weathers 9 |
| March 1, 2028 | @ Rutgers Scarlet Knights* | L 61-73 | 12-17 | N. Hancock 22 | D. Lee 4 | C. Dotson 9 |
| March 8, 2028 | @ Nebraska Cornhuskers Big 10 Tournament | L 60-73 | 12-18 | W. Hancock 16 | D. Lee 10 | J. Weathers 7 |
