| November 15, 2027 | AUBURN TIGERS | W 63-60 | 1-0 | T. Butler 12 | M. Page 5 | B. Cromer 9 |
| November 18, 2027 | TEXAS A&M AGGIES | W 96-69 | 2-0 | M. Pinckney 22 | M. Page 10 | M. McCall 10 |
| November 21, 2027 | DREXEL DRAGONS Charleston Classic | W 95-78 | 3-0 | T. Butler 22 | B. Cromer 5 | M. Pinckney 8 |
| November 22, 2027 | LOYOLA MARYMOUNT LIONS Charleston Classic | W 75-62 | 4-0 | M. Pinckney 21 | M. Page 4 | A. Gebbers 17 |
| November 23, 2027 | MINNESOTA GOLDEN GOPHERS Charleston Classic | W 87-70 | 5-0 | M. Page 16 | T. Butler 7 | B. Cromer 16 |
| November 25, 2027 | #7 GONZAGA BULLDOGS | W 76-69 | 6-0 | T. Butler 21 | M. Page 4 | T. Butler 7 |
| November 29, 2027 | DEPAUL BLUE DEMONS | W 76-60 | 7-0 | M. Pinckney 18 | M. Page 4 | M. Pinckney 15 |
| December 2, 2027 | YALE BULLDOGS | W 81-67 | 8-0 | M. Pinckney 20 | M. Page 5 | B. Cromer 12 |
| December 6, 2027 | OHIO STATE BUCKEYES | W 85-60 | 9-0 | M. Page 20 | M. Page 6 | M. Pinckney 8 |
| December 13, 2027 | TEMPLE OWLS | L 63-73 OT | 9-1 | M. Pinckney 20 | M. Ohnstad 6 | M. Pinckney 10 |
| December 20, 2027 | SAN FRANCISCO DONS (2-6, 0-3 Away) | - | | | | |
| December 26, 2027 | FLORIDA STATE SEMINOLES (7-3, 0-0, 0-0 Away)* | - | | | | |
| December 28, 2027 | BOSTON COLLEGE EAGLES (5-4, 0-0, 0-2 Away)* | - | | | | |
| January 2, 2028 | VIRGINIA TECH HOKIES (5-3, 0-0, 0-1 Away)* | - | | | | |
| January 4, 2028 | SOUTHERN METHODIST MUSTANGS (4-4, 0-0, 0-0 Away)* | - | | | | |
| January 9, 2028 | @ Virginia Cavaliers (9-1, 0-0, 4-0 Home)* | - | | | | |
| January 11, 2028 | MIAMI (FL) HURRICANES (5-2, 0-0, 0-2 Away)* | - | | | | |
| January 16, 2028 | @ Georgia Tech Yellow Jackets (8-1, 0-0, 4-0 Home)* | - | | | | |
| January 18, 2028 | @ NC-State Wolfpack (5-2, 0-0, 5-2 Home)* | - | | | | |
| January 23, 2028 | SYRACUSE ORANGE (3-5, 0-0, 0-0 Away)* | - | | | | |
| January 25, 2028 | WAKE FOREST DEMON DEACONS (6-2, 0-0, 0-1 Away)* | - | | | | |
| January 30, 2028 | @ Clemson Tigers (7-2, 0-0, 7-2 Home)* | - | | | | |
| February 1, 2028 | PITTSBURGH PANTHERS (9-2, 0-0, 0-1 Away)* | - | | | | |
| February 6, 2028 | @ Stanford Cardinal (6-2, 0-0, 6-1 Home)* | - | | | | |
| February 8, 2028 | @ Louisville Cardinals (8-1, 0-0, 5-1 Home)* | - | | | | |
| February 13, 2028 | @ Notre Dame Fighting Irish (5-4, 0-0, 4-3 Home)* | - | | | | |
| February 15, 2028 | CALIFORNIA GOLDEN BEARS (5-3, 0-0, 1-0 Away)* | - | | | | |
| February 20, 2028 | @ Duke Blue Devils (6-4, 0-0, 4-1 Home)* | - | | | | |
| February 22, 2028 | LOUISVILLE CARDINALS (8-1, 0-0, 1-0 Away)* | - | | | | |
| February 27, 2028 | @ Miami (FL) Hurricanes (5-2, 0-0, 5-0 Home)* | - | | | | |
| March 1, 2028 | @ Pittsburgh Panthers (9-2, 0-0, 6-0 Home)* | - | | | | |
