| November 15, 2027 | AUBURN TIGERS | W 63-60 | 1-0 | T. Butler 12 | M. Page 5 | B. Cromer 9 |
| November 18, 2027 | TEXAS A&M AGGIES | W 96-69 | 2-0 | M. Pinckney 22 | M. Page 10 | M. McCall 10 |
| November 21, 2027 | DREXEL DRAGONS Charleston Classic | W 95-78 | 3-0 | T. Butler 22 | B. Cromer 5 | M. Pinckney 8 |
| November 22, 2027 | LOYOLA MARYMOUNT LIONS Charleston Classic | W 75-62 | 4-0 | M. Pinckney 21 | M. Page 4 | A. Gebbers 17 |
| November 23, 2027 | MINNESOTA GOLDEN GOPHERS Charleston Classic | W 87-70 | 5-0 | M. Page 16 | T. Butler 7 | B. Cromer 16 |
| November 25, 2027 | #7 GONZAGA BULLDOGS | W 76-69 | 6-0 | T. Butler 21 | M. Page 4 | T. Butler 7 |
| November 29, 2027 | DEPAUL BLUE DEMONS | W 76-60 | 7-0 | M. Pinckney 18 | M. Page 4 | M. Pinckney 15 |
| December 2, 2027 | YALE BULLDOGS | W 81-67 | 8-0 | M. Pinckney 20 | M. Page 5 | B. Cromer 12 |
| December 6, 2027 | OHIO STATE BUCKEYES | W 85-60 | 9-0 | M. Page 20 | M. Page 6 | M. Pinckney 8 |
| December 13, 2027 | TEMPLE OWLS | L 63-73 OT | 9-1 | M. Pinckney 20 | M. Ohnstad 6 | M. Pinckney 10 |
| December 20, 2027 | SAN FRANCISCO DONS | L 56-63 | 9-2 | T. Butler 17 | M. Page 4 | A. Gebbers 10 |
| December 26, 2027 | FLORIDA STATE SEMINOLES* | W 73-47 | 10-2 | T. Butler 16 | M. McCall 5 | M. Pinckney 9 |
| December 28, 2027 | BOSTON COLLEGE EAGLES* | W 70-60 | 11-2 | M. Page 24 | T. Butler 5 | A. Gebbers 9 |
| January 2, 2028 | VIRGINIA TECH HOKIES* | W 72-55 | 12-2 | M. Page 16 | M. Ohnstad 5 | M. Pinckney 11 |
| January 4, 2028 | SOUTHERN METHODIST MUSTANGS* | W 70-54 | 13-2 | B. Cromer 13 | M. Page 4 | M. Pinckney 9 |
| January 9, 2028 | @ #6 Virginia Cavaliers* | L 58-69 | 13-3 | T. Butler 19 | M. Page 5 | A. Gebbers 9 |
| January 11, 2028 | MIAMI (FL) HURRICANES* | W 76-73 | 14-3 | M. Page 20 | M. Page 4 | M. Pinckney 9 |
| January 16, 2028 | @ Georgia Tech Yellow Jackets* | L 63-78 | 14-4 | M. Page 15 | T. Butler 3 | M. Pinckney 12 |
| January 18, 2028 | @ NC-State Wolfpack* | W 78-52 | 15-4 | M. Pinckney 23 | M. Page 6 | B. Cromer 9 |
| January 23, 2028 | SYRACUSE ORANGE* | W 69-51 | 16-4 | B. Cromer 16 | T. Butler 4 | A. Gebbers 10 |
| January 25, 2028 | WAKE FOREST DEMON DEACONS* | W 68-61 | 17-4 | T. Butler 11 | M. Page 6 | M. Pinckney 10 |
| January 30, 2028 | @ Clemson Tigers* | W 74-73 | 18-4 | T. Butler 22 | M. Page 6 | M. Pinckney 10 |
| February 1, 2028 | #15 PITTSBURGH PANTHERS* | W 71-62 | 19-4 | M. Page 16 | B. Cromer 4 | A. Gebbers 13 |
| February 6, 2028 | @ Stanford Cardinal* | L 59-65 | 19-5 | T. Butler 11 | T. Butler 5 | B. Cromer 7 |
| February 8, 2028 | @ #8 Louisville Cardinals* | W 65-61 | 20-5 | T. Butler 18 | M. Page 2 | M. Pinckney 16 |
| February 13, 2028 | @ Notre Dame Fighting Irish* | W 68-65 | 21-5 | A. Gebbers 17 | B. Cromer 4 | M. Pinckney 10 |
| February 15, 2028 | CALIFORNIA GOLDEN BEARS* | W 51-37 | 22-5 | A. Gebbers 11 | M. Page 4 | A. Gebbers 11 |
| February 20, 2028 | @ #7 Duke Blue Devils* | W 78-62 | 23-5 | T. Butler 28 | M. Page 6 | A. Gebbers 10 |
| February 22, 2028 | #13 LOUISVILLE CARDINALS* | W 80-73 | 24-5 | M. Pinckney 19 | M. Page 11 | A. Gebbers 12 |
| February 27, 2028 | @ Miami (FL) Hurricanes* | W 75-66 | 25-5 | M. Page 16 | A. Gebbers 4 | M. Pinckney 9 |
| March 1, 2028 | @ #14 Pittsburgh Panthers* | W 74-64 | 26-5 | A. Gebbers 16 | T. Butler 8 | M. Pinckney 7 |
| March 10, 2028 | STANFORD CARDINAL ACC Tournament | W 70-56 | 27-5 | M. Pinckney 20 | M. Page 4 | B. Cromer 10 |
| March 11, 2028 | #9 VIRGINIA CAVALIERS ACC Tournament | L 52-68 | 27-6 | T. Butler 13 | M. Page 3 | B. Cromer 9 |
