| November 15, 2027 | SIENA SAINTS | W 82-65 | 1-0 | R. McLean 21 | T. Ohanlon 5 | J. DeVone 10 |
| November 18, 2027 | BOISE STATE BRONCOS | W 93-88 | 2-0 | T. Ohanlon 28 | B. Woodley 5 | T. Ohanlon 6 |
| November 22, 2027 | COLGATE RAIDERS | L 73-84 | 2-1 | T. Ohanlon 17 | B. Woodley 7 | J. DeVone 8 |
| November 25, 2027 | UTAH TECH TRAILBLAZERS | L 67-73 | 2-2 | B. Walker 14 | B. Woodley 4 | R. McLean 11 |
| November 29, 2027 | EASTERN KENTUCKY COLONELS | W 66-57 | 3-2 | B. Walker 13 | R. McLean 5 | T. Ohanlon 10 |
| December 6, 2027 | JACKSON STATE TIGERS | W 64-59 | 4-2 | T. Ohanlon 14 | B. Woodley 4 | B. Walker 10 |
| December 13, 2027 | UTAH VALLEY WOLVERINES | W 74-65 | 5-2 | J. DeVone 19 | B. Woodley 4 | T. Ohanlon 8 |
| December 20, 2027 | FORDHAM RAMS | L 78-83 | 5-3 | T. Ohanlon 26 | B. Woodley 6 | J. DeVone 8 |
| December 23, 2027 | SAINT LOUIS BILLIKENS Gulf Coast Showcase | L 58-67 | 5-4 | T. Ohanlon 18 | B. Woodley 4 | R. McLean 14 |
| December 26, 2027 | NOTRE DAME FIGHTING IRISH* | L 67-70 | 5-5 | B. Woodley 14 | B. Woodley 5 | R. McLean 7 |
| December 28, 2027 | #12 DUKE BLUE DEVILS* | L 69-93 | 5-6 | T. Ohanlon 22 | B. Woodley 4 | B. Walker 8 |
| January 2, 2028 | @ #6 Virginia Cavaliers* | L 65-77 | 5-7 | R. McLean 14 | B. Woodley 5 | T. Ohanlon 6 |
| January 4, 2028 | @ Florida State Seminoles* | W 73-61 | 6-7 | B. Woodley 17 | B. Woodley 4 | B. Walker 8 |
| January 9, 2028 | CALIFORNIA GOLDEN BEARS* | W 66-55 | 7-7 | R. McLean 15 | B. Woodley 5 | J. DeVone 11 |
| January 11, 2028 | @ Virginia Tech Hokies* | L 62-74 | 7-8 | J. DeVone 14 | T. Ohanlon 3 | T. Ohanlon 8 |
| January 16, 2028 | @ #15 Pittsburgh Panthers* | L 75-88 | 7-9 | R. McLean 20 | B. Woodley 3 | B. Walker 9 |
| January 18, 2028 | #12 NORTH CAROLINA TAR HEELS* | L 52-78 | 7-10 | J. DeVone 15 | T. Ohanlon 3 | J. DeVone 4 |
| January 23, 2028 | @ #9 Louisville Cardinals* | L 59-79 | 7-11 | T. Ohanlon 12 | B. Woodley 5 | T. Ohanlon 7 |
| January 25, 2028 | CLEMSON TIGERS* | L 52-65 | 7-12 | B. Woodley 13 | T. Ohanlon 3 | M. Reid 8 |
| January 30, 2028 | MIAMI (FL) HURRICANES* | L 79-82 OT | 7-13 | T. Ohanlon 31 | B. Woodley 7 | T. Ohanlon 7 |
| February 1, 2028 | @ Georgia Tech Yellow Jackets* | L 46-79 | 7-14 | B. Woodley 7 | L. Shaw 2 | J. DeVone 5 |
| February 6, 2028 | @ Wake Forest Demon Deacons* | W 84-67 | 8-14 | T. Ohanlon 22 | B. Woodley 6 | T. Ohanlon 7 |
| February 8, 2028 | @ Stanford Cardinal* | L 40-66 | 8-15 | T. Ohanlon 10 | B. Woodley 4 | S. Logie 12 |
| February 13, 2028 | SYRACUSE ORANGE* | W 75-72 | 9-15 | B. Walker 17 | B. Woodley 4 | R. McLean 7 |
| February 15, 2028 | BOSTON COLLEGE EAGLES* | W 80-65 | 10-15 | J. DeVone 22 | B. Woodley 5 | R. McLean 14 |
| February 20, 2028 | SOUTHERN METHODIST MUSTANGS* | L 77-84 OT | 10-16 | T. Ohanlon 19 | B. Woodley 4 | R. McLean 7 |
| February 22, 2028 | @ Notre Dame Fighting Irish* | L 66-79 | 10-17 | T. Ohanlon 15 | B. Woodley 4 | J. DeVone 9 |
| February 27, 2028 | @ #9 Duke Blue Devils* | L 61-62 | 10-18 | T. Ohanlon 12 | B. Forrest 4 | L. Shaw 8 |
| March 1, 2028 | FLORIDA STATE SEMINOLES* | W 70-57 | 11-18 | B. Walker 19 | B. Woodley 6 | J. DeVone 7 |
