| November 14, 2027 | HAWAII RAINBOW WARRIORS NIT Preseason Tip Off | W 90-63 | 1-0 | A. Moss 21 | D. Austin 5 | C. Gaines 13 |
| November 16, 2027 | WICHITA STATE SHOCKERS NIT Preseason Tip Off | W 91-75 | 2-0 | C. Gaines 23 | D. Austin 5 | C. Gaines 12 |
| November 18, 2027 | #8 LOUISVILLE CARDINALS NIT Preseason Tip Off | W 102-92 | 3-0 | D. Austin 22 | D. Austin 6 | J. Ausler 6 |
| November 20, 2027 | #5 HOUSTON COUGARS NIT Preseason Tip Off | W 93-82 | 4-0 | C. Gaines 19 | D. Austin 4 | C. Gaines 14 |
| November 23, 2027 | KENT STATE GOLDEN FLASHES | W 78-52 | 5-0 | C. Gaines 15 | D. Austin 9 | C. Gaines 13 |
| November 26, 2027 | @ #8 Kentucky Wildcats | W 100-76 | 6-0 | J. Ausler 24 | D. Austin 6 | C. Gaines 9 |
| November 30, 2027 | @ #15 Alabama Crimson Tide | L 51-78 | 6-1 | A. Moss 13 | D. Austin 4 | J. Broussard 10 |
| December 3, 2027 | NEVADA-LAS VEGAS RUNNIN' REBELS | W 89-80 | 7-1 | A. Moss 20 | D. Austin 4 | J. Ausler 12 |
| December 7, 2027 | WASHINGTON STATE COUGARS | W 96-64 | 8-1 | J. Ausler 24 | D. Austin 3 | C. Gaines 14 |
| December 14, 2027 | YALE BULLDOGS | W 87-57 | 9-1 | A. Moss 26 | D. Austin 4 | C. Gaines 13 |
| December 21, 2027 | UC-SANTA BARBARA GAUCHOS | W 100-81 | 10-1 | D. Austin 24 | D. Austin 9 | C. Gaines 12 |
| December 24, 2027 | @ #23 Vanderbilt Commodores | L 75-80 | 10-2 | J. Ausler 28 | A. Moss 5 | B. Jenkins 9 |
| December 26, 2027 | NEBRASKA CORNHUSKERS* | W 74-70 | 11-2 | J. Ausler 17 | D. Austin 5 | C. Gaines 12 |
| December 28, 2027 | #13 PURDUE BOILERMAKERS* | W 95-82 | 12-2 | A. Moss 23 | J. Ausler 5 | J. Broussard 9 |
| January 2, 2028 | @ Penn State Nittany Lions* | W 77-60 | 13-2 | J. Ausler 27 | D. Austin 8 | C. Gaines 13 |
| January 4, 2028 | @ Maryland Terrapins* | W 89-70 | 14-2 | A. Moss 24 | J. Ausler 5 | D. Austin 7 |
| January 9, 2028 | #20 MICHIGAN WOLVERINES* | W 99-95 | 15-2 | D. Austin 30 | D. Austin 5 | J. Broussard 15 |
| January 11, 2028 | ILLINOIS FIGHTING ILLINI* | L 79-97 | 15-3 | A. Moss 19 | D. Austin 6 | C. Gaines 14 |
| January 16, 2028 | @ Northwestern Wildcats* | W 94-80 | 16-3 | A. Moss 27 | D. Austin 11 | C. Gaines 9 |
| January 18, 2028 | RUTGERS SCARLET KNIGHTS* | W 88-67 | 17-3 | A. Moss 25 | D. Austin 7 | C. Gaines 12 |
| January 23, 2028 | @ #15 Oregon Ducks* | W 100-98 | 18-3 | J. Ausler 26 | D. Austin 8 | C. Gaines 11 |
| January 25, 2028 | @ UCLA Bruins* | W 100-90 | 19-3 | J. Ausler 31 | H. East 4 | C. Gaines 9 |
| January 30, 2028 | @ Washington Huskies* | W 105-74 | 20-3 | A. Moss 24 | J. Ausler 6 | C. Gaines 16 |
| February 1, 2028 | @ Southern California Trojans* | W 84-82 OT | 21-3 | A. Moss 29 | D. Austin 5 | C. Gaines 12 |
| February 6, 2028 | OHIO STATE BUCKEYES* | W 105-91 | 22-3 | A. Moss 24 | D. Austin 5 | C. Gaines 18 |
| February 8, 2028 | INDIANA HOOSIERS* | W 91-64 | 23-3 | A. Moss 21 | A. Moss 5 | C. Gaines 10 |
| February 13, 2028 | @ #4 Wisconsin Badgers* | L 70-86 | 23-4 | A. Moss 20 | D. Austin 5 | C. Gaines 11 |
| February 15, 2028 | @ Iowa Hawkeyes* | W 87-76 | 24-4 | H. East 20 | J. Lane 4 | J. Broussard 11 |
| February 20, 2028 | MINNESOTA GOLDEN GOPHERS* | W 98-85 | 25-4 | J. Ausler 26 | D. Austin 9 | C. Gaines 15 |
| February 22, 2028 | MARYLAND TERRAPINS* | W 75-61 | 26-4 | J. Ausler 23 | D. Austin 4 | C. Gaines 12 |
| February 27, 2028 | @ Nebraska Cornhuskers* | W 92-82 | 27-4 | J. Ausler 20 | D. Austin 5 | C. Gaines 10 |
| March 1, 2028 | PENN STATE NITTANY LIONS* | W 84-72 | 28-4 | A. Moss 17 | D. Austin 7 | C. Gaines 17 |
| March 10, 2028 | TBD Big 10 Tournament | - | | | | |
