| November 16, 2027 | JACKSONVILLE DOLPHINS | W 74-61 | 1-0 | P. Althoff 18 | J. Wrenn 8 | R. Perry 9 |
| November 18, 2027 | #22 XAVIER MUSKETEERS | W 90-83 | 2-0 | A. Johnson 30 | J. Wrenn 9 | P. Althoff 13 |
| November 21, 2027 | INDIANA STATE SYCAMORES Charleston Classic | W 89-76 | 3-0 | A. Johnson 33 | J. Wrenn 3 | P. Althoff 7 |
| November 22, 2027 | TEXAS TECH RED RAIDERS Charleston Classic | W 84-69 | 4-0 | P. Althoff 18 | A. Johnson 5 | E. Clark 12 |
| November 23, 2027 | @ #12 North Carolina Tar Heels Charleston Classic | L 70-87 | 4-1 | A. Johnson 15 | E. Clark 3 | E. Clark 9 |
| November 26, 2027 | WEST GEORGIA WOLFPACK | W 86-67 | 5-1 | P. Althoff 29 | A. Johnson 6 | E. Clark 10 |
| November 28, 2027 | @ St. Bonaventure Bonnies | L 69-80 | 5-2 | P. Althoff 20 | E. Clark 3 | E. Clark 9 |
| December 2, 2027 | WAGNER SEAHAWKS | W 76-58 | 6-2 | P. Althoff 18 | J. Wrenn 4 | E. Clark 15 |
| December 6, 2027 | @ Butler Bulldogs | L 67-77 | 6-3 | B. Hill 16 | R. Perry 7 | R. Perry 6 |
| December 14, 2027 | LIBERTY FLAMES | W 94-74 | 7-3 | A. Johnson 22 | J. Wrenn 8 | E. Clark 10 |
| December 20, 2027 | ILLINOIS STATE REDBIRDS | L 82-85 | 7-4 | J. Thompson 15 | R. Perry 4 | R. Perry 13 |
| December 26, 2027 | PENN STATE NITTANY LIONS* | W 91-71 | 8-4 | J. Wrenn 18 | J. Wrenn 6 | E. Clark 10 |
| December 28, 2027 | #3 MICHIGAN WOLVERINES* | W 85-73 | 9-4 | A. Johnson 28 | J. Wrenn 5 | R. Perry 8 |
| January 2, 2028 | @ #19 Wisconsin Badgers* | L 57-79 | 9-5 | A. Johnson 13 | J. Wrenn 5 | E. Clark 7 |
| January 4, 2028 | PURDUE BOILERMAKERS* | L 65-72 | 9-6 | A. Johnson 14 | A. Johnson 4 | P. Althoff 7 |
| January 9, 2028 | @ #13 Maryland Terrapins* | L 70-96 | 9-7 | B. Hill 18 | R. Perry 5 | E. Clark 9 |
| January 11, 2028 | @ #22 Michigan State Spartans* | L 67-73 | 9-8 | J. Wrenn 18 | J. Wrenn 4 | P. Althoff 9 |
| January 16, 2028 | @ Illinois Fighting Illini* | L 72-81 | 9-9 | P. Althoff 18 | J. Wrenn 5 | R. Perry 8 |
| January 18, 2028 | WASHINGTON HUSKIES* | W 70-63 | 10-9 | J. Thompson 16 | J. Thompson 4 | R. Perry 9 |
| January 23, 2028 | SOUTHERN CALIFORNIA TROJANS* | W 98-84 OT | 11-9 | J. Wrenn 22 | J. Thompson 5 | D. Hunter 14 |
| January 25, 2028 | @ Oregon Ducks* | L 76-92 | 11-10 | J. Thompson 22 | J. Thompson 6 | P. Althoff 8 |
| January 30, 2028 | @ Rutgers Scarlet Knights* | W 81-74 | 12-10 | A. Johnson 29 | J. Wrenn 10 | E. Clark 9 |
| February 1, 2028 | UCLA BRUINS* | W 72-64 | 13-10 | A. Johnson 19 | R. Perry 4 | E. Clark 7 |
| February 6, 2028 | NORTHWESTERN WILDCATS* | L 61-67 | 13-11 | P. Althoff 20 | J. Wrenn 4 | E. Clark 10 |
| February 8, 2028 | INDIANA HOOSIERS* | W 79-55 | 14-11 | A. Johnson 24 | J. Wrenn 6 | E. Clark 17 |
| February 13, 2028 | OHIO STATE BUCKEYES* | L 78-86 | 14-12 | A. Johnson 21 | J. Wrenn 3 | D. Hunter 7 |
| February 15, 2028 | @ Nebraska Cornhuskers* | L 83-84 | 14-13 | P. Althoff 15 | J. Wrenn 4 | E. Clark 10 |
| February 20, 2028 | @ Iowa Hawkeyes* | W 82-78 | 15-13 | A. Johnson 27 | J. Wrenn 5 | E. Clark 12 |
| February 22, 2028 | @ Purdue Boilermakers* | W 81-68 | 16-13 | P. Althoff 24 | J. Wrenn 6 | P. Althoff 9 |
| February 27, 2028 | OREGON DUCKS* | W 84-72 | 17-13 | J. Wrenn 20 | J. Wrenn 5 | E. Clark 8 |
| March 1, 2028 | @ UCLA Bruins* | W 69-61 | 18-13 | A. Johnson 19 | A. Johnson 4 | R. Perry 11 |
| March 9, 2028 | NEBRASKA CORNHUSKERS Big 10 Tournament | L 77-86 | 18-14 | A. Johnson 14 | J. Wrenn 6 | P. Althoff 9 |
