| November 16, 2027 | @ #9 Florida Gators | L 77-88 | 0-1 | N. Vickers 14 | N. Vickers 5 | C. Rivera 13 |
| November 19, 2027 | EASTERN ILLINOIS PANTHERS | W 86-64 | 1-1 | N. Vickers 21 | J. Williams 8 | N. Vickers 11 |
| November 22, 2027 | BINGHAMTON BEARCATS | W 95-79 | 2-1 | J. Williams 20 | C. Hale 3 | C. Rivera 8 |
| November 30, 2027 | SOUTHERN UTAH THUNDERBIRDS | W 74-72 | 3-1 | A. Ray 14 | P. Tracy 4 | N. Vickers 7 |
| December 3, 2027 | SOUTHERN ILLINOIS SALUKIS | L 63-81 | 3-2 | J. Williams 12 | J. Williams 3 | N. Vickers 10 |
| December 7, 2027 | UTAH TECH TRAILBLAZERS | W 74-69 | 4-2 | C. Rivera 16 | C. Rivera 4 | C. Rivera 10 |
| December 9, 2027 | WINTHROP EAGLES Nassau Championship | W 77-60 | 5-2 | N. Vickers 18 | J. Williams 5 | C. Rivera 7 |
| December 10, 2027 | SETON HALL PIRATES Nassau Championship | W 69-66 | 6-2 | N. Vickers 12 | J. Williams 4 | C. Rivera 7 |
| December 11, 2027 | @ #23 Michigan Wolverines Nassau Championship | L 65-81 | 6-3 | C. Hale 10 | J. Williams 2 | N. Vickers 7 |
| December 14, 2027 | ALCORN STATE BRAVES | L 76-91 | 6-4 | C. Rivera 14 | J. Williams 5 | N. Vickers 6 |
| December 21, 2027 | MASSACHUSETTS MINUTEMEN | W 88-75 | 7-4 | J. Williams 23 | C. Rivera 6 | C. Rivera 12 |
| December 26, 2027 | NC-STATE WOLFPACK* | W 74-58 | 8-4 | N. Vickers 28 | J. Williams 5 | C. Rivera 10 |
| December 28, 2027 | #22 CLEMSON TIGERS* | W 64-59 | 9-4 | C. Rivera 15 | J. Williams 5 | N. Vickers 10 |
| January 2, 2028 | #21 NORTH CAROLINA TAR HEELS* | W 78-70 | 10-4 | J. Blanchard 12 | J. Williams 3 | N. Vickers 10 |
| January 4, 2028 | @ Georgia Tech Yellow Jackets* | W 76-69 | 11-4 | C. Rivera 21 | B. Spence 4 | N. Vickers 7 |
| January 9, 2028 | PITTSBURGH PANTHERS* | W 76-56 | 12-4 | N. Vickers 17 | J. Williams 6 | J. Williams 7 |
| January 11, 2028 | SOUTHERN METHODIST MUSTANGS* | L 75-87 | 12-5 | J. Williams 14 | J. Williams 6 | J. Williams 8 |
| January 16, 2028 | @ California Golden Bears* | L 59-71 | 12-6 | J. Williams 13 | B. Spence 2 | J. Williams 5 |
| January 18, 2028 | FLORIDA STATE SEMINOLES* | W 79-74 | 13-6 | C. Rivera 14 | J. Williams 5 | N. Vickers 7 |
| January 23, 2028 | @ Wake Forest Demon Deacons* | W 82-76 | 14-6 | J. Williams 22 | B. Spence 5 | J. Williams 9 |
| January 25, 2028 | #10 LOUISVILLE CARDINALS* | L 52-66 | 14-7 | J. Blanchard 10 | J. Williams 2 | N. Vickers 11 |
| January 30, 2028 | #18 SYRACUSE ORANGE* | W 71-58 | 15-7 | B. Spence 20 | J. Williams 9 | N. Vickers 10 |
| February 1, 2028 | @ Notre Dame Fighting Irish* | W 71-65 | 16-7 | B. Spence 22 | B. Spence 4 | C. Rivera 7 |
| February 6, 2028 | @ #1 Duke Blue Devils* | L 56-78 | 16-8 | J. Williams 10 | B. Spence 2 | N. Vickers 11 |
| February 8, 2028 | @ Boston College Eagles* | L 72-80 | 16-9 | N. Vickers 17 | B. Spence 5 | C. Rivera 12 |
| February 13, 2028 | @ #12 Virginia Cavaliers* | L 88-97 | 16-10 | J. Williams 19 | B. Spence 6 | J. Williams 5 |
| February 15, 2028 | @ Stanford Cardinal* | W 97-87 | 17-10 | J. Williams 23 | J. Williams 4 | N. Vickers 12 |
| February 20, 2028 | VIRGINIA TECH HOKIES* | W 86-83 OT | 18-10 | N. Vickers 14 | J. Blanchard 5 | C. Rivera 8 |
| February 22, 2028 | STANFORD CARDINAL* | W 85-68 | 19-10 | B. Spence 23 | J. Williams 7 | W. Gomes 8 |
| February 27, 2028 | @ #8 Louisville Cardinals* | L 69-90 | 19-11 | B. Spence 13 | B. Spence 4 | J. Winder 7 |
| March 1, 2028 | @ Virginia Tech Hokies* | W 80-73 | 20-11 | N. Vickers 16 | C. Hale 5 | C. Rivera 9 |
| March 9, 2028 | TBD ACC Tournament | - | | | | |
