| November 15, 2027 | NIAGARA PURPLE EAGLES | W 80-76 | 1-0 | T. Leep 14 | J. Dickens 5 | C. Cameron 12 |
| November 18, 2027 | @ UCLA Bruins | L 62-86 | 1-1 | T. Leep 20 | J. Dickens 9 | C. Cameron 8 |
| November 22, 2027 | BELLARMINE KNIGHTS | W 78-76 | 2-1 | D. Pastner 20 | J. Dickens 6 | J. Drayton 10 |
| November 25, 2027 | RIDER BRONCS | W 77-61 | 3-1 | D. Pastner 17 | J. Dickens 6 | C. Cameron 13 |
| November 29, 2027 | @ Richmond Spiders | L 62-87 | 3-2 | D. Pastner 16 | J. Dickens 6 | C. Cameron 9 |
| December 6, 2027 | TEXAS-EL PASO MINERS | W 75-67 | 4-2 | D. Pastner 16 | J. Dickens 5 | C. Cameron 10 |
| December 13, 2027 | SOUTHERN MISSISSIPPI GOLDEN EAGLES | W 88-65 | 5-2 | J. Dickens 25 | J. Dickens 6 | C. Cameron 8 |
| December 20, 2027 | TENNESSEE STATE TIGERS (3-5, 1-2 Away) | - | | | | |
| December 23, 2027 | SOUTHERN MISSISSIPPI GOLDEN EAGLES (3-5, 2-4 Away) Empire Classic | - | | | | |
| December 26, 2027 | @ Louisville Cardinals (8-1, 0-0, 5-1 Home)* | - | | | | |
| December 28, 2027 | @ Stanford Cardinal (6-2, 0-0, 6-1 Home)* | - | | | | |
| January 2, 2028 | @ Georgia Tech Yellow Jackets (8-1, 0-0, 4-0 Home)* | - | | | | |
| January 4, 2028 | WAKE FOREST DEMON DEACONS (6-2, 0-0, 0-1 Away)* | - | | | | |
| January 9, 2028 | PITTSBURGH PANTHERS (9-2, 0-0, 0-1 Away)* | - | | | | |
| January 11, 2028 | @ North Carolina Tar Heels (9-1, 0-0, 6-1 Home)* | - | | | | |
| January 16, 2028 | @ Southern Methodist Mustangs (4-4, 0-0, 3-3 Home)* | - | | | | |
| January 18, 2028 | CALIFORNIA GOLDEN BEARS (5-3, 0-0, 1-0 Away)* | - | | | | |
| January 23, 2028 | VIRGINIA CAVALIERS (9-1, 0-0, 2-1 Away)* | - | | | | |
| January 25, 2028 | @ Virginia Tech Hokies (5-3, 0-0, 5-2 Home)* | - | | | | |
| January 30, 2028 | @ NC-State Wolfpack (5-2, 0-0, 5-2 Home)* | - | | | | |
| February 1, 2028 | DUKE BLUE DEVILS (6-4, 0-0, 0-2 Away)* | - | | | | |
| February 6, 2028 | @ Boston College Eagles (5-4, 0-0, 4-1 Home)* | - | | | | |
| February 8, 2028 | NOTRE DAME FIGHTING IRISH (5-4, 0-0, 0-0 Away)* | - | | | | |
| February 13, 2028 | FLORIDA STATE SEMINOLES (7-3, 0-0, 0-0 Away)* | - | | | | |
| February 15, 2028 | CLEMSON TIGERS (7-2, 0-0, 0-0 Away)* | - | | | | |
| February 20, 2028 | @ Syracuse Orange (3-5, 0-0, 3-4 Home)* | - | | | | |
| February 22, 2028 | @ Wake Forest Demon Deacons (6-2, 0-0, 6-0 Home)* | - | | | | |
| February 27, 2028 | NORTH CAROLINA TAR HEELS (9-1, 0-0, 0-0 Away)* | - | | | | |
| March 1, 2028 | SYRACUSE ORANGE (3-5, 0-0, 0-0 Away)* | - | | | | |
