| November 15, 2027 | NIAGARA PURPLE EAGLES | W 80-76 | 1-0 | T. Leep 14 | J. Dickens 5 | C. Cameron 12 |
| November 18, 2027 | @ UCLA Bruins | L 62-86 | 1-1 | T. Leep 20 | J. Dickens 9 | C. Cameron 8 |
| November 22, 2027 | BELLARMINE KNIGHTS | W 78-76 | 2-1 | D. Pastner 20 | J. Dickens 6 | J. Drayton 10 |
| November 25, 2027 | RIDER BRONCS | W 77-61 | 3-1 | D. Pastner 17 | J. Dickens 6 | C. Cameron 13 |
| November 29, 2027 | @ Richmond Spiders | L 62-87 | 3-2 | D. Pastner 16 | J. Dickens 6 | C. Cameron 9 |
| December 6, 2027 | TEXAS-EL PASO MINERS | W 75-67 | 4-2 | D. Pastner 16 | J. Dickens 5 | C. Cameron 10 |
| December 13, 2027 | SOUTHERN MISSISSIPPI GOLDEN EAGLES | W 88-65 | 5-2 | J. Dickens 25 | J. Dickens 6 | C. Cameron 8 |
| December 20, 2027 | TENNESSEE STATE TIGERS | W 74-69 | 6-2 | T. Leep 18 | J. Dickens 5 | T. Leep 9 |
| December 23, 2027 | SOUTHERN MISSISSIPPI GOLDEN EAGLES Empire Classic | L 59-81 | 6-3 | T. Leep 14 | J. Dickens 5 | C. Cameron 13 |
| December 26, 2027 | @ #14 Louisville Cardinals* | L 50-71 | 6-4 | J. Dickens 11 | D. Pastner 1 | C. Cameron 9 |
| December 28, 2027 | @ Stanford Cardinal* | L 84-89 | 6-5 | W. Hampton 20 | J. Dickens 4 | W. Hampton 7 |
| January 2, 2028 | @ Georgia Tech Yellow Jackets* | L 90-95 | 6-6 | D. Pastner 19 | J. Dickens 3 | C. Cameron 8 |
| January 4, 2028 | WAKE FOREST DEMON DEACONS* | L 66-71 | 6-7 | T. Leep 13 | D. Pastner 3 | T. Leep 10 |
| January 9, 2028 | #16 PITTSBURGH PANTHERS* | L 74-84 | 6-8 | C. Cameron 15 | J. Dickens 7 | C. Cameron 7 |
| January 11, 2028 | @ #10 North Carolina Tar Heels* | L 73-76 | 6-9 | D. Pastner 16 | D. Pastner 7 | T. Leep 6 |
| January 16, 2028 | @ Southern Methodist Mustangs* | L 57-66 | 6-10 | C. Cameron 15 | J. Dickens 4 | J. Drayton 13 |
| January 18, 2028 | CALIFORNIA GOLDEN BEARS* | W 82-72 | 7-10 | D. Pastner 16 | J. Dickens 7 | C. Cameron 10 |
| January 23, 2028 | #6 VIRGINIA CAVALIERS* | W 77-59 | 8-10 | C. Cameron 15 | J. Dickens 4 | C. Cameron 7 |
| January 25, 2028 | @ Virginia Tech Hokies* | L 49-77 | 8-11 | D. Pastner 9 | J. Dickens 3 | T. Leep 7 |
| January 30, 2028 | @ NC-State Wolfpack* | W 82-79 OT | 9-11 | C. Cameron 17 | C. Cameron 4 | J. Drayton 13 |
| February 1, 2028 | #7 DUKE BLUE DEVILS* | W 80-59 | 10-11 | J. Dickens 22 | J. Dickens 4 | C. Cameron 11 |
| February 6, 2028 | @ Boston College Eagles* | L 82-92 | 10-12 | C. Cameron 21 | J. Dickens 8 | C. Cameron 9 |
| February 8, 2028 | NOTRE DAME FIGHTING IRISH* | W 74-59 | 11-12 | J. Drayton 19 | J. Dickens 5 | T. Leep 8 |
| February 13, 2028 | FLORIDA STATE SEMINOLES* | W 78-71 | 12-12 | T. Leep 20 | J. Dickens 8 | C. Cameron 14 |
| February 15, 2028 | CLEMSON TIGERS* | W 88-68 | 13-12 | J. Dickens 17 | B. Reid 10 | C. Cameron 10 |
| February 20, 2028 | @ Syracuse Orange* | L 69-73 | 13-13 | C. Cameron 12 | B. Reid 3 | B. Andrews 7 |
| February 22, 2028 | @ Wake Forest Demon Deacons* | L 72-93 | 13-14 | C. Cameron 20 | J. Dickens 6 | C. Cameron 10 |
| February 27, 2028 | #7 NORTH CAROLINA TAR HEELS* | L 66-75 | 13-15 | J. Dickens 13 | J. Dickens 4 | J. Drayton 5 |
| March 1, 2028 | SYRACUSE ORANGE* | W 88-66 | 14-15 | C. Cameron 20 | J. Dickens 5 | C. Cameron 10 |
| March 8, 2028 | WAKE FOREST DEMON DEACONS ACC Tournament | W 82-79 | 15-15 | J. Dickens 21 | B. Reid 5 | J. Drayton 8 |
| March 9, 2028 | @ #17 Louisville Cardinals ACC Tournament | L 72-88 | 15-16 | J. Dickens 17 | J. Dickens 6 | J. Dickens 6 |
