| November 15, 2027 | @ Arkansas Razorbacks | W 72-61 | 1-0 | E. Beck 24 | C. Hurd 5 | I. Ekpeyong 7 |
| November 18, 2027 | @ Texas Tech Red Raiders | L 69-87 | 1-1 | E. Beck 19 | C. McCarthy 6 | I. Ekpeyong 9 |
| November 22, 2027 | #13 BUTLER BULLDOGS | W 68-61 | 2-1 | C. McCarthy 19 | C. McCarthy 5 | C. Hurd 6 |
| November 29, 2027 | SOUTH CAROLINA GAMECOCKS | W 74-44 | 3-1 | C. McCarthy 13 | C. Hurd 6 | C. Hurd 10 |
| December 6, 2027 | UC-SANTA BARBARA GAUCHOS | W 90-69 | 4-1 | E. Beck 23 | E. Beck 5 | I. Ekpeyong 7 |
| December 9, 2027 | COLORADO STATE RAMS | W 60-54 | 5-1 | C. Hurd 15 | E. Beck 5 | D. Rozier 9 |
| December 13, 2027 | SAN DIEGO STATE AZTECS | W 77-76 OT | 6-1 | D. Rozier 22 | E. Beck 5 | D. Rozier 14 |
| December 20, 2027 | ARIZONA STATE SUN DEVILS | L 71-74 | 6-2 | C. Hurd 18 | C. Hurd 4 | I. Ekpeyong 8 |
| December 23, 2027 | FAIRFIELD STAGS Gulf Coast Showcase | W 59-56 | 7-2 | C. Hurd 16 | E. Beck 3 | I. Ekpeyong 9 |
| December 24, 2027 | SAINT LOUIS BILLIKENS Gulf Coast Showcase | W 73-60 | 8-2 | I. Ekpeyong 15 | C. McCarthy 4 | C. Hurd 7 |
| December 25, 2027 | TEXAS CHRISTIAN HORNED FROGS Gulf Coast Showcase | L 72-80 | 8-3 | E. Beck 23 | C. McCarthy 8 | C. Hurd 11 |
| December 26, 2027 | RUTGERS SCARLET KNIGHTS* | W 71-68 | 9-3 | E. Beck 21 | E. Beck 6 | C. Hurd 6 |
| December 28, 2027 | @ Indiana Hoosiers* | L 59-89 | 9-4 | C. Hurd 15 | R. Renault 4 | D. Rozier 8 |
| January 2, 2028 | @ Oregon Ducks* | W 85-75 | 10-4 | E. Beck 25 | E. Beck 5 | I. Ekpeyong 9 |
| January 4, 2028 | WASHINGTON HUSKIES* | W 61-44 | 11-4 | I. Ekpeyong 17 | C. Hurd 3 | I. Ekpeyong 10 |
| January 9, 2028 | @ Southern California Trojans* | L 69-77 | 11-5 | E. Beck 19 | C. McCarthy 4 | I. Ekpeyong 10 |
| January 11, 2028 | MINNESOTA GOLDEN GOPHERS* | W 73-67 | 12-5 | C. Hurd 19 | E. Beck 6 | C. Hurd 7 |
| January 16, 2028 | @ Iowa Hawkeyes* | L 69-85 | 12-6 | C. McCarthy 19 | E. Beck 3 | C. Hurd 7 |
| January 18, 2028 | NEBRASKA CORNHUSKERS* | W 92-67 | 13-6 | C. Hurd 21 | E. Beck 8 | C. McCarthy 7 |
| January 23, 2028 | @ UCLA Bruins* | L 61-78 | 13-7 | C. McCarthy 19 | E. Beck 7 | C. McCarthy 7 |
| January 25, 2028 | @ Illinois Fighting Illini* | L 55-66 | 13-8 | C. McCarthy 19 | E. Beck 5 | C. McCarthy 8 |
| January 30, 2028 | #23 WISCONSIN BADGERS* | W 80-77 OT | 14-8 | C. Hurd 17 | E. Beck 6 | C. Hurd 7 |
| February 1, 2028 | @ #2 Michigan Wolverines* | L 52-65 | 14-9 | E. Beck 12 | E. Beck 5 | C. McCarthy 7 |
| February 6, 2028 | #20 PURDUE BOILERMAKERS* | W 68-60 | 15-9 | D. Rozier 18 | R. Renault 4 | I. Ekpeyong 9 |
| February 8, 2028 | #12 MARYLAND TERRAPINS* | W 68-64 | 16-9 | C. McCarthy 24 | C. Hurd 4 | C. Hurd 15 |
| February 13, 2028 | @ Penn State Nittany Lions* | W 81-75 OT | 17-9 | E. Beck 19 | E. Beck 6 | I. Ekpeyong 13 |
| February 15, 2028 | @ Ohio State Buckeyes* | W 69-60 | 18-9 | E. Beck 25 | R. Renault 5 | I. Ekpeyong 7 |
| February 20, 2028 | NORTHWESTERN WILDCATS* | L 46-61 | 18-10 | C. Hurd 10 | E. Beck 5 | I. Ekpeyong 9 |
| February 22, 2028 | IOWA HAWKEYES* | W 79-65 | 19-10 | C. Hurd 26 | E. Beck 6 | E. Adams 8 |
| February 27, 2028 | INDIANA HOOSIERS* | W 85-79 | 20-10 | C. Hurd 23 | E. Beck 6 | E. Adams 9 |
| March 1, 2028 | @ Nebraska Cornhuskers* | L 74-79 | 20-11 | C. Hurd 16 | E. Beck 6 | I. Ekpeyong 9 |
| March 9, 2028 | WASHINGTON HUSKIES Big 10 Tournament | L 60-63 | 20-12 | E. Beck 14 | E. Beck 4 | C. McCarthy 9 |
