| November 16, 2027 | CAL ST. FULLERTON TITANS | W 74-60 | 1-0 | T. Brinson 15 | R. Hart 4 | B. Goodwyn 7 |
| November 19, 2027 | BROWN BEARS | W 71-49 | 2-0 | J. Ford 14 | R. Hart 5 | J. Ford 10 |
| November 21, 2027 | JACKSONVILLE STATE GAMECOCKS Charleston Classic | W 78-62 | 3-0 | J. Ford 16 | R. Hart 6 | B. Goodwyn 5 |
| November 22, 2027 | CENTRAL FLORIDA KNIGHTS Charleston Classic | W 64-59 | 4-0 | T. Brinson 27 | R. Hart 6 | R. Hart 5 |
| November 23, 2027 | SYRACUSE ORANGE Charleston Classic | L 61-78 | 4-1 | A. Mallet 12 | T. Brinson 3 | A. Mallet 8 |
| November 26, 2027 | SOUTH DAKOTA STATE JACKRABBITS | W 84-71 | 5-1 | A. Mallet 16 | R. Hart 5 | A. Mallet 7 |
| November 29, 2027 | MASSACHUSETTS MINUTEMEN | W 66-59 | 6-1 | J. Ford 12 | R. Hart 4 | A. Mallet 8 |
| December 3, 2027 | LIBERTY FLAMES | W 59-55 | 7-1 | T. Brinson 14 | B. Goodwyn 3 | A. Mallet 12 |
| December 7, 2027 | NORTHERN COLORADO BEARS | W 72-53 | 8-1 | J. Ford 14 | R. Hart 5 | A. Mallet 7 |
| December 13, 2027 | #8 WISCONSIN BADGERS | L 80-92 | 8-2 | J. Ford 18 | R. Hart 8 | A. Mallet 7 |
| December 21, 2027 | @ Utah Utes | W 73-64 | 9-2 | T. Brinson 19 | B. Goodwyn 2 | G. Cunningham 9 |
| December 26, 2027 | @ Villanova Wildcats* | W 70-66 | 10-2 | T. Brinson 10 | R. Hart 6 | J. Ford 11 |
| December 30, 2027 | #20 CREIGHTON BLUE JAYS* | L 81-102 | 10-3 | R. Hart 22 | R. Hart 7 | A. Mallet 11 |
| January 2, 2028 | @ Georgetown Hoyas* | L 74-81 | 10-4 | T. Brinson 16 | R. Hart 6 | J. Ford 12 |
| January 4, 2028 | @ St. Johns Red Storm* | W 83-76 | 11-4 | T. Brinson 15 | D. Harris 4 | A. Mallet 7 |
| January 6, 2028 | SETON HALL PIRATES* | W 73-61 | 12-4 | T. Brinson 15 | T. Brinson 3 | J. Ford 8 |
| January 11, 2028 | @ DePaul Blue Demons* | L 64-72 | 12-5 | T. Brinson 20 | R. Hart 5 | T. Brinson 11 |
| January 13, 2028 | @ #9 Connecticut Huskies* | L 54-71 | 12-6 | B. Goodwyn 9 | T. Brinson 4 | A. Mallet 8 |
| January 20, 2028 | PROVIDENCE FRIARS* | W 84-81 | 13-6 | T. Brinson 22 | R. Hart 4 | B. Goodwyn 5 |
| January 23, 2028 | ST. JOHNS RED STORM* | W 92-71 | 14-6 | T. Brinson 19 | R. Hart 10 | G. Cunningham 6 |
| January 27, 2028 | BUTLER BULLDOGS* | W 74-63 | 15-6 | A. Mallet 22 | T. Brinson 3 | A. Mallet 7 |
| January 30, 2028 | XAVIER MUSKETEERS* | W 82-73 | 16-6 | B. Goodwyn 15 | R. Hart 4 | B. Goodwyn 6 |
| February 1, 2028 | @ Seton Hall Pirates* | W 85-66 | 17-6 | G. Cunningham 21 | R. Hart 5 | J. Ford 9 |
| February 3, 2028 | @ #13 Creighton Blue Jays* | L 65-66 | 17-7 | T. Brinson 14 | R. Hart 4 | J. Ford 11 |
| February 8, 2028 | #9 CONNECTICUT HUSKIES* | W 94-81 | 18-7 | T. Brinson 20 | R. Hart 9 | J. Ford 6 |
| February 10, 2028 | DEPAUL BLUE DEMONS* | W 86-54 | 19-7 | J. Ford 16 | J. Drayton 5 | J. Ford 10 |
| February 15, 2028 | @ Butler Bulldogs* | L 68-77 | 19-8 | T. Brinson 16 | R. Hart 4 | J. Ford 9 |
| February 17, 2028 | @ Xavier Musketeers* | W 72-65 | 20-8 | R. Hart 13 | R. Hart 3 | A. Mallet 10 |
| February 22, 2028 | GEORGETOWN HOYAS* | W 98-83 | 21-8 | T. Brinson 19 | G. Cunningham 5 | A. Mallet 11 |
| February 24, 2028 | VILLANOVA WILDCATS* | W 76-65 | 22-8 | G. Cunningham 17 | R. Hart 4 | B. Goodwyn 5 |
| March 1, 2028 | @ Providence Friars* | W 72-67 | 23-8 | J. Ford 13 | R. Hart 6 | T. Brinson 6 |
| March 10, 2028 | TBD Big East Tournament | - | | | | |
