| November 15, 2027 | SAN FRANCISCO DONS | W 92-81 | 1-0 | G. Murphy 28 | G. Murphy 6 | P. Fitz 14 |
| November 18, 2027 | OHIO BOBCATS | W 80-63 | 2-0 | G. Murphy 21 | G. Murphy 5 | P. Fitz 9 |
| November 22, 2027 | @ #19 Creighton Blue Jays | W 97-86 | 3-0 | P. Fitz 23 | G. Murphy 4 | P. Fitz 13 |
| November 25, 2027 | GEORGE WASHINGTON REVOLUTIONARIES | W 90-64 | 4-0 | P. Fitz 31 | G. Murphy 8 | P. Fitz 12 |
| November 29, 2027 | #23 SETON HALL PIRATES | L 88-94 | 4-1 | P. Fitz 24 | G. Murphy 6 | P. Fitz 11 |
| December 6, 2027 | SAINT JOSEPHS HAWKS | W 85-70 | 5-1 | P. Fitz 30 | C. Rose 4 | P. Fitz 12 |
| December 13, 2027 | KENTUCKY WILDCATS | W 88-70 | 6-1 | C. Rose 21 | G. Murphy 3 | P. Fitz 11 |
| December 16, 2027 | EAST TENNESSEE STATE BUCCANEERS Battle 4 Atlantis | W 91-62 | 7-1 | C. Rose 24 | G. Murphy 6 | P. Fitz 21 |
| December 17, 2027 | COLORADO BUFFALOES Battle 4 Atlantis | W 79-63 | 8-1 | C. Rose 21 | G. Murphy 7 | J. Oliver 11 |
| December 18, 2027 | WISCONSIN BADGERS Battle 4 Atlantis | L 75-85 | 8-2 | G. Murphy 19 | M. Collier 4 | J. Oliver 8 |
| December 20, 2027 | CHARLESTON COUGARS | W 98-80 | 9-2 | P. Fitz 19 | P. Fitz 8 | A. Bayless 8 |
| December 26, 2027 | MIAMI (FL) HURRICANES* | W 71-50 | 10-2 | P. Fitz 25 | G. Murphy 5 | P. Fitz 15 |
| December 28, 2027 | @ Southern Methodist Mustangs* | W 94-75 | 11-2 | G. Murphy 29 | G. Murphy 11 | M. Collier 9 |
| January 2, 2028 | CALIFORNIA GOLDEN BEARS* | W 90-73 | 12-2 | J. Oliver 21 | C. Rose 5 | J. Oliver 11 |
| January 4, 2028 | NOTRE DAME FIGHTING IRISH* | W 83-74 | 13-2 | G. Murphy 22 | G. Murphy 7 | P. Fitz 9 |
| January 9, 2028 | @ Boston College Eagles* | W 82-71 | 14-2 | P. Fitz 33 | G. Murphy 9 | P. Fitz 17 |
| January 11, 2028 | @ #6 Virginia Cavaliers* | L 103-105 OT | 14-3 | G. Murphy 36 | G. Murphy 7 | P. Fitz 14 |
| January 16, 2028 | SYRACUSE ORANGE* | W 99-71 | 15-3 | C. Rose 19 | G. Murphy 4 | J. Oliver 12 |
| January 18, 2028 | @ Virginia Tech Hokies* | W 83-62 | 16-3 | P. Fitz 21 | G. Murphy 6 | P. Fitz 10 |
| January 23, 2028 | NC-STATE WOLFPACK* | W 79-59 | 17-3 | G. Murphy 22 | M. Collier 5 | P. Fitz 13 |
| January 25, 2028 | @ #14 Pittsburgh Panthers* | W 86-82 OT | 18-3 | P. Fitz 20 | G. Murphy 9 | J. Oliver 11 |
| January 30, 2028 | GEORGIA TECH YELLOW JACKETS* | L 64-73 | 18-4 | G. Murphy 20 | G. Murphy 4 | J. Oliver 11 |
| February 1, 2028 | WAKE FOREST DEMON DEACONS* | W 78-62 | 19-4 | C. Rose 21 | G. Murphy 9 | P. Fitz 12 |
| February 6, 2028 | @ Clemson Tigers* | L 68-78 | 19-5 | C. Rose 22 | C. Rose 4 | P. Fitz 9 |
| February 8, 2028 | #11 NORTH CAROLINA TAR HEELS* | L 61-65 | 19-6 | M. Collier 11 | M. Collier 3 | P. Fitz 9 |
| February 13, 2028 | @ Stanford Cardinal* | L 58-71 | 19-7 | C. Rose 27 | G. Murphy 6 | P. Fitz 13 |
| February 15, 2028 | #8 DUKE BLUE DEVILS* | L 83-86 | 19-8 | G. Murphy 26 | G. Murphy 7 | P. Fitz 11 |
| February 20, 2028 | @ Florida State Seminoles* | L 59-71 | 19-9 | C. Rose 17 | G. Murphy 4 | J. Oliver 10 |
| February 22, 2028 | @ #8 North Carolina Tar Heels* | L 73-80 | 19-10 | P. Fitz 21 | G. Murphy 4 | P. Fitz 16 |
| February 27, 2028 | #14 PITTSBURGH PANTHERS* | W 90-68 | 20-10 | P. Fitz 24 | G. Murphy 6 | P. Fitz 14 |
| March 1, 2028 | @ California Golden Bears* | W 54-51 | 21-10 | P. Fitz 12 | M. Collier 5 | P. Fitz 11 |
| March 9, 2028 | MIAMI (FL) HURRICANES ACC Tournament | W 88-72 | 22-10 | P. Fitz 17 | G. Murphy 7 | J. Oliver 10 |
| March 10, 2028 | @ #10 Duke Blue Devils ACC Tournament | L 67-83 | 22-11 | C. Rose 15 | G. Murphy 5 | C. Rose 5 |
