| November 15, 2027 | SAN FRANCISCO DONS | W 92-81 | 1-0 | G. Murphy 28 | G. Murphy 6 | P. Fitz 14 |
| November 18, 2027 | OHIO BOBCATS | W 80-63 | 2-0 | G. Murphy 21 | G. Murphy 5 | P. Fitz 9 |
| November 22, 2027 | @ #19 Creighton Blue Jays | W 97-86 | 3-0 | P. Fitz 23 | G. Murphy 4 | P. Fitz 13 |
| November 25, 2027 | GEORGE WASHINGTON REVOLUTIONARIES | W 90-64 | 4-0 | P. Fitz 31 | G. Murphy 8 | P. Fitz 12 |
| November 29, 2027 | #23 SETON HALL PIRATES | L 88-94 | 4-1 | P. Fitz 24 | G. Murphy 6 | P. Fitz 11 |
| December 6, 2027 | SAINT JOSEPHS HAWKS | W 85-70 | 5-1 | P. Fitz 30 | C. Rose 4 | P. Fitz 12 |
| December 13, 2027 | KENTUCKY WILDCATS | W 88-70 | 6-1 | C. Rose 21 | G. Murphy 3 | P. Fitz 11 |
| December 16, 2027 | EAST TENNESSEE STATE BUCCANEERS Battle 4 Atlantis | W 91-62 | 7-1 | C. Rose 24 | G. Murphy 6 | P. Fitz 21 |
| December 17, 2027 | COLORADO BUFFALOES Battle 4 Atlantis | W 79-63 | 8-1 | C. Rose 21 | G. Murphy 7 | J. Oliver 11 |
| December 18, 2027 | WISCONSIN BADGERS (6-2, 1-1 Away) Battle 4 Atlantis | - | | | | |
| December 20, 2027 | CHARLESTON COUGARS (5-4, 1-3 Away) | - | | | | |
| December 26, 2027 | MIAMI (FL) HURRICANES (5-2, 0-0, 0-2 Away)* | - | | | | |
| December 28, 2027 | @ Southern Methodist Mustangs (4-4, 0-0, 3-3 Home)* | - | | | | |
| January 2, 2028 | CALIFORNIA GOLDEN BEARS (5-3, 0-0, 1-0 Away)* | - | | | | |
| January 4, 2028 | NOTRE DAME FIGHTING IRISH (5-4, 0-0, 0-0 Away)* | - | | | | |
| January 9, 2028 | @ Boston College Eagles (5-4, 0-0, 4-1 Home)* | - | | | | |
| January 11, 2028 | @ Virginia Cavaliers (9-1, 0-0, 4-0 Home)* | - | | | | |
| January 16, 2028 | SYRACUSE ORANGE (3-5, 0-0, 0-0 Away)* | - | | | | |
| January 18, 2028 | @ Virginia Tech Hokies (5-3, 0-0, 5-2 Home)* | - | | | | |
| January 23, 2028 | NC-STATE WOLFPACK (5-2, 0-0, 0-0 Away)* | - | | | | |
| January 25, 2028 | @ Pittsburgh Panthers (9-2, 0-0, 6-0 Home)* | - | | | | |
| January 30, 2028 | GEORGIA TECH YELLOW JACKETS (8-1, 0-0, 1-1 Away)* | - | | | | |
| February 1, 2028 | WAKE FOREST DEMON DEACONS (6-2, 0-0, 0-1 Away)* | - | | | | |
| February 6, 2028 | @ Clemson Tigers (7-2, 0-0, 7-2 Home)* | - | | | | |
| February 8, 2028 | NORTH CAROLINA TAR HEELS (9-1, 0-0, 0-0 Away)* | - | | | | |
| February 13, 2028 | @ Stanford Cardinal (6-2, 0-0, 6-1 Home)* | - | | | | |
| February 15, 2028 | DUKE BLUE DEVILS (6-4, 0-0, 0-2 Away)* | - | | | | |
| February 20, 2028 | @ Florida State Seminoles (7-3, 0-0, 5-2 Home)* | - | | | | |
| February 22, 2028 | @ North Carolina Tar Heels (9-1, 0-0, 6-1 Home)* | - | | | | |
| February 27, 2028 | PITTSBURGH PANTHERS (9-2, 0-0, 0-1 Away)* | - | | | | |
| March 1, 2028 | @ California Golden Bears (5-3, 0-0, 4-2 Home)* | - | | | | |
