| November 16, 2027 | @ Pittsburgh Panthers | W 80-67 | 1-0 | K. Kittles 22 | K. Kittles 5 | K. Kittles 11 |
| November 18, 2027 | PORTLAND STATE VIKINGS Sunshine Slam | W 81-50 | 2-0 | D. Mann 22 | B. Reeder 3 | A. Simpson 13 |
| November 19, 2027 | GEORGIA BULLDOGS Sunshine Slam | W 83-57 | 3-0 | A. Simpson 20 | B. Reeder 5 | D. Mann 9 |
| November 20, 2027 | #13 NOTRE DAME FIGHTING IRISH Sunshine Slam | W 72-44 | 4-0 | A. Simpson 20 | D. Mann 6 | A. Simpson 14 |
| November 23, 2027 | CLEMSON TIGERS | W 67-54 | 5-0 | A. Simpson 30 | C. Gunder 8 | D. Mann 11 |
| November 24, 2027 | #20 UC-SAN DIEGO TRITONS | W 75-57 | 6-0 | K. Kittles 18 | K. Kittles 4 | A. Simpson 15 |
| November 28, 2027 | NEVADA-LAS VEGAS RUNNIN' REBELS | W 72-64 | 7-0 | A. Simpson 23 | D. Mann 3 | A. Simpson 17 |
| December 1, 2027 | @ Memphis Tigers | L 87-102 | 7-1 | D. Mann 24 | C. Gunder 8 | A. Simpson 8 |
| December 5, 2027 | WASHINGTON HUSKIES | W 65-51 | 8-1 | A. Simpson 25 | D. Mann 5 | D. Mann 11 |
| December 12, 2027 | @ Wichita State Shockers | L 70-72 | 8-2 | K. Kittles 21 | C. Gunder 5 | D. Mann 8 |
| December 21, 2027 | OHIO STATE BUCKEYES | W 74-55 | 9-2 | A. Simpson 22 | A. Simpson 4 | A. Simpson 12 |
| December 26, 2027 | @ Arizona Wildcats* | W 89-72 | 10-2 | B. Reeder 24 | C. Gunder 5 | D. Mann 9 |
| December 30, 2027 | #8 IOWA STATE CYCLONES* | W 84-73 | 11-2 | C. Gunder 24 | A. Simpson 4 | B. Reeder 8 |
| January 2, 2028 | @ Texas Christian Horned Frogs* | W 90-63 | 12-2 | A. Simpson 20 | C. Gunder 9 | A. Simpson 17 |
| January 6, 2028 | WEST VIRGINIA MOUNTAINEERS* | W 95-60 | 13-2 | K. Kittles 29 | C. Gunder 5 | D. Mann 10 |
| January 11, 2028 | UTAH UTES* | W 94-58 | 14-2 | A. Simpson 26 | B. Reeder 7 | A. Simpson 11 |
| January 16, 2028 | @ Baylor Bears* | W 79-74 | 15-2 | K. Kittles 22 | B. Darden 4 | A. Simpson 9 |
| January 18, 2028 | CINCINNATI BEARCATS* | W 80-68 | 16-2 | A. Simpson 21 | C. Gunder 6 | D. Mann 11 |
| January 20, 2028 | @ Colorado Buffaloes* | W 75-66 | 17-2 | C. Gunder 14 | B. Reeder 3 | D. Mann 14 |
| January 25, 2028 | @ Arizona State Sun Devils* | W 71-70 | 18-2 | K. Kittles 17 | D. Mann 6 | A. Simpson 15 |
| January 30, 2028 | OKLAHOMA STATE COWBOYS* | W 76-66 | 19-2 | D. Mann 17 | C. Gunder 7 | A. Simpson 10 |
| February 1, 2028 | CENTRAL FLORIDA KNIGHTS* | W 89-71 | 20-2 | D. Mann 27 | B. Reeder 5 | D. Mann 9 |
| February 3, 2028 | @ #19 Houston Cougars* | W 76-66 | 21-2 | D. Mann 25 | C. Gunder 4 | D. Mann 10 |
| February 8, 2028 | TEXAS TECH RED RAIDERS* | W 77-71 | 22-2 | B. Reeder 18 | B. Reeder 8 | D. Mann 7 |
| February 10, 2028 | @ #3 Brigham Young Cougars* | L 71-88 | 22-3 | D. Mann 23 | C. Gunder 4 | B. Reeder 7 |
| February 15, 2028 | ARIZONA STATE SUN DEVILS* | W 84-57 | 23-3 | K. Kittles 20 | D. Mann 6 | D. Mann 8 |
| February 17, 2028 | @ Kansas State Wildcats* | W 82-75 OT | 24-3 | K. Kittles 22 | C. Gunder 4 | D. Mann 8 |
| February 22, 2028 | @ Central Florida Knights* | L 88-90 OT | 24-4 | K. Kittles 28 | D. Mann 7 | W. Bonner 10 |
| February 24, 2028 | COLORADO BUFFALOES* | W 77-60 | 25-4 | D. Mann 20 | D. Mann 5 | D. Mann 13 |
| March 1, 2028 | BAYLOR BEARS* | W 69-52 | 26-4 | A. Simpson 24 | C. Gunder 5 | C. Gunder 11 |
| March 3, 2028 | @ Oklahoma State Cowboys* | W 97-93 | 27-4 | C. Gunder 23 | I. Ivey 5 | A. Simpson 7 |
| March 10, 2028 | TBD Big 12 Tournament | - | | | | |
