| November 14, 2027 | RIDER BRONCS | W 97-64 | 1-0 | D. Debro 20 | D. Miles 9 | D. Debro 9 |
| November 19, 2027 | #13 PURDUE BOILERMAKERS | W 85-79 | 2-0 | D. Miles 13 | D. Miles 5 | C. Nichols 11 |
| November 21, 2027 | BELMONT BRUINS | W 95-68 | 3-0 | M. Washington 20 | D. Miles 10 | C. Nichols 10 |
| November 30, 2027 | @ #7 Wisconsin Badgers | L 70-89 | 3-1 | T. Hjoch 17 | D. Miles 6 | C. Nichols 10 |
| December 1, 2027 | MISSOURI STATE BEARS | L 69-79 | 3-2 | C. Nichols 13 | D. Miles 7 | D. Debro 11 |
| December 5, 2027 | TEXAS STATE BOBCATS | W 74-53 | 4-2 | D. Miles 17 | D. Miles 8 | C. Nichols 12 |
| December 8, 2027 | MONTANA STATE BOBCATS | W 90-68 | 5-2 | D. Debro 16 | D. Miles 12 | C. Nichols 7 |
| December 12, 2027 | VALPARAISO BEACONS | W 90-63 | 6-2 | M. Washington 17 | G. Charbonneau 5 | M. Washington 7 |
| December 19, 2027 | CHICAGO STATE COUGARS | W 98-71 | 7-2 | T. Hjoch 19 | D. Miles 9 | D. Debro 10 |
| December 26, 2027 | @ #8 Iowa State Cyclones* | L 97-103 | 7-3 | D. Debro 24 | T. Hjoch 7 | D. Debro 8 |
| December 30, 2027 | ARIZONA WILDCATS* | W 78-75 | 8-3 | G. Charbonneau 14 | D. Miles 7 | I. Thunell 11 |
| January 4, 2028 | @ Baylor Bears* | L 66-78 | 8-4 | C. Nichols 22 | T. Hjoch 4 | C. Nichols 7 |
| January 6, 2028 | CINCINNATI BEARCATS* | W 104-78 | 9-4 | C. Nichols 22 | T. Hjoch 9 | D. Debro 7 |
| January 11, 2028 | @ Oklahoma State Cowboys* | W 90-85 | 10-4 | G. Charbonneau 20 | D. Miles 7 | C. Nichols 9 |
| January 13, 2028 | #4 BRIGHAM YOUNG COUGARS* | L 83-98 | 10-5 | T. Hjoch 18 | T. Hjoch 5 | D. Debro 7 |
| January 18, 2028 | ARIZONA STATE SUN DEVILS* | W 89-71 | 11-5 | C. Nichols 25 | D. Miles 7 | C. Nichols 14 |
| January 20, 2028 | @ West Virginia Mountaineers* | W 107-101 | 12-5 | D. Miles 23 | D. Miles 11 | C. Nichols 7 |
| January 25, 2028 | @ Utah Utes* | W 75-62 | 13-5 | C. Nichols 18 | B. Carroll 5 | C. Nichols 9 |
| January 30, 2028 | CENTRAL FLORIDA KNIGHTS* | W 79-65 | 14-5 | C. Nichols 18 | D. Miles 6 | C. Nichols 7 |
| February 1, 2028 | @ Colorado Buffaloes* | W 89-78 | 15-5 | C. Nichols 19 | D. Miles 12 | D. Debro 13 |
| February 3, 2028 | WEST VIRGINIA MOUNTAINEERS* | W 114-90 | 16-5 | T. Hjoch 23 | D. Miles 8 | C. Nichols 14 |
| February 8, 2028 | UTAH UTES* | W 95-78 | 17-5 | C. Nichols 17 | D. Miles 13 | G. Charbonneau 9 |
| February 10, 2028 | @ Houston Cougars* | L 74-88 | 17-6 | T. Hjoch 26 | G. Charbonneau 5 | D. Debro 9 |
| February 15, 2028 | @ Central Florida Knights* | W 75-69 | 18-6 | D. Debro 13 | D. Miles 3 | C. Nichols 9 |
| February 17, 2028 | #5 KANSAS JAYHAWKS* | L 75-82 OT | 18-7 | C. Nichols 16 | D. Miles 6 | D. Debro 13 |
| February 22, 2028 | BAYLOR BEARS* | W 90-84 | 19-7 | D. Debro 21 | D. Miles 7 | D. Debro 10 |
| February 24, 2028 | @ Texas Christian Horned Frogs* | L 81-92 | 19-8 | C. Nichols 20 | T. Hjoch 7 | D. Debro 9 |
| March 1, 2028 | #12 IOWA STATE CYCLONES* | L 90-93 | 19-9 | G. Charbonneau 25 | D. Miles 9 | D. Miles 7 |
| March 3, 2028 | @ Texas Tech Red Raiders* | W 80-76 | 20-9 | C. Nichols 17 | D. Miles 7 | D. Debro 6 |
| March 10, 2028 | TBD Big 12 Tournament | - | | | | |
