| November 14, 2027 | IONA GAELS | W 82-64 | 1-0 | R. Jamison 16 | M. Price 4 | D. Harmon 13 |
| November 17, 2027 | OHIO BOBCATS | W 92-59 | 2-0 | R. Jamison 23 | M. Price 8 | T. Dilligard 10 |
| November 21, 2027 | WOFFORD TERRIERS | W 89-69 | 3-0 | R. Jamison 23 | M. Price 5 | R. Abrams 8 |
| November 26, 2027 | #17 NC-STATE WOLFPACK | W 76-64 | 4-0 | R. Jamison 16 | N. Beshara 4 | T. Dilligard 12 |
| November 28, 2027 | @ UCLA Bruins | W 75-72 | 5-0 | J. Cleveland 20 | M. Price 8 | D. Harmon 11 |
| December 1, 2027 | @ Stanford Cardinal | W 111-92 | 6-0 | M. Price 22 | M. Price 4 | D. Harmon 10 |
| December 5, 2027 | SOUTH FLORIDA BULLS | W 96-56 | 7-0 | N. Beshara 17 | M. Price 5 | T. Dilligard 9 |
| December 13, 2027 | @ Iowa Hawkeyes | W 86-80 | 8-0 | V. Raif 22 | M. Price 6 | D. Harmon 9 |
| December 19, 2027 | BUFFALO BULLS | W 82-65 | 9-0 | J. Cleveland 19 | T. Dilligard 5 | T. Dilligard 6 |
| December 26, 2027 | KANSAS STATE WILDCATS* | W 103-97 | 10-0 | J. Cleveland 25 | M. Price 7 | D. Harmon 8 |
| December 30, 2027 | @ #4 Kansas Jayhawks* | L 73-84 | 10-1 | M. Price 19 | M. Price 6 | D. Harmon 13 |
| January 4, 2028 | @ Texas Tech Red Raiders* | W 93-83 | 11-1 | J. Cleveland 25 | S. Levi 4 | J. Cleveland 5 |
| January 6, 2028 | TEXAS CHRISTIAN HORNED FROGS* | W 106-88 | 12-1 | R. Jamison 18 | M. Price 8 | T. Dilligard 10 |
| January 9, 2028 | ARIZONA STATE SUN DEVILS* | W 99-91 | 13-1 | J. Cleveland 22 | M. Price 5 | D. Harmon 10 |
| January 13, 2028 | @ Cincinnati Bearcats* | W 115-99 | 14-1 | T. Dilligard 24 | M. Price 4 | T. Dilligard 11 |
| January 18, 2028 | @ Baylor Bears* | W 95-84 | 15-1 | J. Cleveland 24 | S. Levi 6 | T. Dilligard 12 |
| January 20, 2028 | CENTRAL FLORIDA KNIGHTS* | W 92-79 | 16-1 | J. Cleveland 30 | M. Price 3 | R. Jamison 8 |
| January 25, 2028 | TEXAS TECH RED RAIDERS* | W 99-55 | 17-1 | J. Cleveland 30 | M. Price 13 | J. Cleveland 8 |
| January 27, 2028 | @ #17 Houston Cougars* | W 85-80 | 18-1 | J. Cleveland 28 | M. Price 10 | T. Dilligard 9 |
| February 1, 2028 | @ #4 Brigham Young Cougars* | L 83-96 | 18-2 | R. Jamison 24 | M. Price 9 | T. Dilligard 7 |
| February 3, 2028 | CINCINNATI BEARCATS* | W 102-89 | 19-2 | R. Jamison 22 | J. Cleveland 5 | D. Harmon 8 |
| February 8, 2028 | #16 ARIZONA WILDCATS* | W 98-77 | 20-2 | R. Jamison 26 | M. Price 7 | T. Dilligard 12 |
| February 10, 2028 | @ West Virginia Mountaineers* | L 107-108 | 20-3 | R. Jamison 19 | M. Price 8 | T. Dilligard 9 |
| February 13, 2028 | @ Utah Utes* | L 78-88 | 20-4 | J. Cleveland 19 | M. Price 4 | D. Harmon 9 |
| February 20, 2028 | #2 BRIGHAM YOUNG COUGARS* | W 96-86 | 21-4 | M. Price 30 | M. Price 6 | D. Harmon 12 |
| February 22, 2028 | @ Colorado Buffaloes* | W 102-101 | 22-4 | T. Dilligard 29 | M. Price 8 | T. Dilligard 9 |
| February 27, 2028 | OKLAHOMA STATE COWBOYS* | W 89-70 | 23-4 | M. Price 21 | M. Price 11 | T. Dilligard 10 |
| March 1, 2028 | @ Kansas State Wildcats* | W 93-90 | 24-4 | J. Cleveland 21 | M. Price 6 | D. Harmon 9 |
| March 3, 2028 | HOUSTON COUGARS* | W 91-86 | 25-4 | J. Cleveland 23 | M. Price 6 | D. Harmon 11 |
| March 10, 2028 | TBD Big 12 Tournament | - | | | | |
