| November 14, 2027 | @ Richmond Spiders | L 74-85 | 0-1 | J. Clyburn 20 | L. Stanley 7 | J. Curry 7 |
| November 17, 2027 | PRESBYTERIAN BLUE HOSE | W 96-76 | 1-1 | J. Curry 20 | L. Stanley 9 | J. Clyburn 11 |
| November 21, 2027 | GEORGE MASON PATRIOTS WSSN Classic | L 60-72 | 1-2 | J. Clyburn 15 | L. Stanley 3 | L. Stanley 12 |
| November 29, 2027 | @ #1 Marquette Golden Eagles | L 90-104 | 1-3 | J. Curry 22 | L. Evans 3 | L. Stanley 5 |
| December 1, 2027 | ALBANY GREAT DANES | W 72-69 | 2-3 | J. Hogue 16 | J. Hogue 5 | J. Clyburn 7 |
| December 7, 2027 | LIBERTY FLAMES | W 86-79 | 3-3 | L. Stanley 17 | J. Hogue 3 | L. Evans 9 |
| December 13, 2027 | #16 IOWA STATE CYCLONES | L 73-76 | 3-4 | J. Clyburn 17 | L. Stanley 5 | L. Evans 8 |
| December 16, 2027 | MISSISSIPPI STATE BULLDOGS | L 62-66 | 3-5 | J. Curry 12 | J. Clyburn 3 | J. Curry 8 |
| December 21, 2027 | NORTH FLORIDA OSPREY (4-6, 1-5 Away) | - | | | | |
| December 26, 2027 | @ Southern California Trojans (5-3, 0-0, 5-3 Home)* | - | | | | |
| December 28, 2027 | UCLA BRUINS (8-2, 0-0, 1-0 Away)* | - | | | | |
| January 2, 2028 | @ Northwestern Wildcats (5-3, 0-0, 5-1 Home)* | - | | | | |
| January 4, 2028 | OREGON DUCKS (4-5, 0-0, 0-1 Away)* | - | | | | |
| January 9, 2028 | @ Washington Huskies (5-3, 0-0, 5-2 Home)* | - | | | | |
| January 11, 2028 | INDIANA HOOSIERS (4-4, 0-0, 1-2 Away)* | - | | | | |
| January 16, 2028 | MICHIGAN STATE SPARTANS (6-1, 0-0, 1-1 Away)* | - | | | | |
| January 18, 2028 | OHIO STATE BUCKEYES (6-3, 0-0, 1-2 Away)* | - | | | | |
| January 23, 2028 | @ Maryland Terrapins (6-2, 0-0, 5-0 Home)* | - | | | | |
| January 25, 2028 | MICHIGAN WOLVERINES (10-0, 0-0, 0-0 Away)* | - | | | | |
| January 30, 2028 | @ Purdue Boilermakers (6-3, 0-0, 5-2 Home)* | - | | | | |
| February 1, 2028 | @ Illinois Fighting Illini (6-3, 0-0, 6-1 Home)* | - | | | | |
| February 6, 2028 | @ Nebraska Cornhuskers (4-4, 0-0, 4-2 Home)* | - | | | | |
| February 8, 2028 | @ Penn State Nittany Lions (3-4, 0-0, 3-3 Home)* | - | | | | |
| February 13, 2028 | WISCONSIN BADGERS (6-2, 0-0, 1-1 Away)* | - | | | | |
| February 15, 2028 | RUTGERS SCARLET KNIGHTS (5-4, 0-0, 0-1 Away)* | - | | | | |
| February 20, 2028 | MINNESOTA GOLDEN GOPHERS (7-3, 0-0, 0-2 Away)* | - | | | | |
| February 22, 2028 | @ Michigan State Spartans (6-1, 0-0, 5-0 Home)* | - | | | | |
| February 27, 2028 | SOUTHERN CALIFORNIA TROJANS (5-3, 0-0, 0-0 Away)* | - | | | | |
| March 1, 2028 | @ Wisconsin Badgers (6-2, 0-0, 3-1 Home)* | - | | | | |
