| November 14, 2027 | @ Washington Huskies | W 69-67 | 1-0 | B. Claxton 18 | A. Prince 3 | C. Vines 11 |
| November 18, 2027 | @ Harvard Crimson | L 75-100 | 1-1 | B. Claxton 14 | A. Prince 6 | J. Hannah 10 |
| November 21, 2027 | @ Minnesota Golden Gophers Charleston Classic | L 76-89 | 1-2 | B. Claxton 18 | C. Wheat 7 | C. Vines 10 |
| November 28, 2027 | @ Arkansas Razorbacks | W 81-69 | 2-2 | C. Vines 18 | C. Wheat 6 | C. Vines 13 |
| December 2, 2027 | FLORIDA ATLANTIC OWLS | L 73-74 | 2-3 | C. Vines 20 | A. Prince 4 | C. Vines 8 |
| December 6, 2027 | @ DePaul Blue Demons | L 61-86 | 2-4 | C. Wheat 16 | A. Prince 5 | J. Hannah 12 |
| December 14, 2027 | NORTH FLORIDA OSPREY | L 74-82 | 2-5 | C. Wheat 19 | A. Prince 6 | J. Hannah 8 |
| December 15, 2027 | @ Charleston Southern Buccaneers | L 80-82 | 2-6 | B. Claxton 17 | B. Claxton 3 | B. Claxton 9 |
| December 19, 2027 | @ Erie Freighters | L 66-78 | 2-7 | A. Prince 15 | A. Shepard 3 | C. Vines 8 |
| December 26, 2027 | @ Northern Iowa Panthers* | L 60-80 | 2-8 | A. Prince 17 | A. Prince 3 | C. Vines 11 |
| December 29, 2027 | @ Belmont Bruins* | L 73-91 | 2-9 | B. Claxton 15 | B. Claxton 6 | J. Hannah 8 |
| January 2, 2028 | MISSOURI STATE BEARS* | W 70-58 | 3-9 | A. Prince 11 | A. Prince 6 | C. Murphy 8 |
| January 5, 2028 | EVANSVILLE PURPLE ACES* | W 66-48 | 4-9 | A. Prince 14 | A. Prince 4 | C. Vines 14 |
| January 9, 2028 | MURRAY STATE RACERS* | L 78-91 | 4-10 | B. Claxton 18 | A. Prince 10 | C. Vines 6 |
| January 12, 2028 | @ Drake Bulldogs* | W 83-76 | 5-10 | B. Claxton 23 | A. Prince 6 | A. Prince 6 |
| January 16, 2028 | SOUTHERN ILLINOIS SALUKIS* | W 72-56 | 6-10 | J. Hannah 18 | A. Prince 8 | J. Hannah 15 |
| January 19, 2028 | @ Bradley Braves* | L 74-95 | 6-11 | J. Hannah 17 | E. Dunkley 4 | J. Hannah 9 |
| January 23, 2028 | @ Valparaiso Beacons* | L 83-93 | 6-12 | B. Claxton 22 | C. Wheat 5 | J. Hannah 9 |
| January 26, 2028 | @ Southern Illinois Salukis* | L 61-75 | 6-13 | B. Claxton 13 | A. Prince 4 | J. Hannah 8 |
| January 30, 2028 | BRADLEY BRAVES* | W 68-67 | 7-13 | A. Prince 15 | C. Wheat 10 | J. Hannah 10 |
| February 2, 2028 | VALPARAISO BEACONS* | W 77-67 | 8-13 | C. Wheat 20 | A. Prince 8 | J. Hannah 7 |
| February 6, 2028 | DRAKE BULLDOGS* | W 67-58 | 9-13 | J. Hannah 15 | A. Prince 8 | J. Hannah 13 |
| February 9, 2028 | ILLINOIS-CHICAGO FLAMES* | W 86-74 | 10-13 | C. Wheat 17 | A. Prince 8 | J. Hannah 8 |
| February 13, 2028 | @ Missouri State Bears* | L 77-89 | 10-14 | C. Vines 11 | A. Prince 3 | B. Claxton 7 |
| February 16, 2028 | @ Evansville Purple Aces* | L 55-73 | 10-15 | C. Murphy 11 | A. Prince 2 | C. Vines 10 |
| February 20, 2028 | NORTHERN IOWA PANTHERS* | L 63-76 | 10-16 | J. Hannah 14 | A. Prince 4 | C. Vines 13 |
| February 23, 2028 | BELMONT BRUINS* | L 72-87 | 10-17 | A. Prince 16 | A. Prince 3 | J. Hannah 11 |
| February 27, 2028 | @ Illinois-Chicago Flames* | L 71-80 | 10-18 | A. Prince 16 | B. Claxton 5 | C. Vines 11 |
| March 2, 2028 | @ Illinois State Redbirds* | L 60-86 | 10-19 | B. Claxton 17 | A. Prince 5 | C. Vines 10 |
| March 7, 2028 | @ Valparaiso Beacons MVC Tournament | L 69-90 | 10-20 | J. Hannah 22 | E. Dunkley 5 | J. Hannah 11 |
