| November 16, 2025 | @ Brigham Young Cougars | L 60-83 | 0-1 | C. James 14 | D. Bibby 3 | J. Palmer 9 |
| November 23, 2025 | MANHATTAN JASPERS | L 55-76 | 0-2 | D. Bibby 12 | L. Angner 3 | J. Palmer 10 |
| November 26, 2025 | WICHITA STATE SHOCKERS | W 69-65 OT | 1-2 | C. James 15 | B. Davis 3 | C. James 11 |
| November 30, 2025 | MARIST RED FOXES | W 76-71 | 2-2 | A. Xavier 14 | D. Bibby 3 | A. Xavier 6 |
| December 3, 2025 | AUSTIN PEAY GOVERNORS | W 76-67 | 3-2 | C. James 17 | C. James 3 | J. Palmer 6 |
| December 7, 2025 | COASTAL CAROLINA CHANTICLEERS | L 58-66 | 3-3 | C. James 12 | J. Palmer 5 | J. Palmer 6 |
| December 13, 2025 | #9 MISSOURI TIGERS | L 72-78 | 3-4 | D. Bibby 19 | A. Xavier 6 | D. Bibby 5 |
| December 20, 2025 | GARDNER-WEBB RUNNIN' BULLDOGS | W 77-62 | 4-4 | C. James 29 | D. Bibby 3 | B. Jackson 6 |
| December 23, 2025 | CENTRAL FLORIDA KNIGHTS Empire Classic | L 59-76 | 4-5 | D. Bibby 14 | J. Palmer 3 | J. Palmer 8 |
| December 26, 2025 | @ #13 UCLA Bruins* | W 59-56 | 5-5 | C. James 16 | D. Bibby 4 | A. Xavier 9 |
| December 28, 2025 | OREGON DUCKS* | L 66-84 | 5-6 | D. Bibby 17 | D. Bibby 3 | A. Xavier 7 |
| January 2, 2026 | @ Iowa Hawkeyes* | L 66-76 | 5-7 | D. Bibby 13 | D. Bibby 5 | A. Xavier 5 |
| January 4, 2026 | @ #8 Michigan State Spartans* | W 61-58 | 6-7 | C. James 15 | D. Bibby 4 | A. Xavier 6 |
| January 9, 2026 | @ Ohio State Buckeyes* | L 60-71 | 6-8 | D. Bibby 13 | D. Bibby 3 | A. Xavier 6 |
| January 11, 2026 | @ #13 Southern California Trojans* | W 85-74 | 7-8 | D. Bibby 16 | D. Bibby 5 | D. Bibby 6 |
| January 16, 2026 | WASHINGTON HUSKIES* | L 79-91 | 7-9 | L. Angner 15 | B. Davis 4 | L. Angner 4 |
| January 18, 2026 | @ Purdue Boilermakers* | L 73-91 | 7-10 | C. James 19 | D. Bibby 5 | B. Jackson 6 |
| January 23, 2026 | @ Minnesota Golden Gophers* | L 52-79 | 7-11 | C. James 11 | C. James 2 | L. Angner 6 |
| January 25, 2026 | WISCONSIN BADGERS* | L 75-82 | 7-12 | A. Xavier 16 | D. Bibby 4 | A. Xavier 7 |
| January 30, 2026 | NORTHWESTERN WILDCATS* | W 72-60 | 8-12 | D. Bibby 13 | D. Bibby 5 | A. Xavier 5 |
| February 1, 2026 | NEBRASKA CORNHUSKERS* | L 56-68 | 8-13 | C. James 10 | J. Palmer 3 | L. Angner 5 |
| February 6, 2026 | @ Rutgers Scarlet Knights* | L 56-86 | 8-14 | A. Xavier 10 | D. Bibby 4 | A. Xavier 5 |
| February 8, 2026 | MICHIGAN WOLVERINES* | L 58-66 | 8-15 | D. Bibby 19 | J. Palmer 5 | C. James 4 |
| February 13, 2026 | INDIANA HOOSIERS* | W 75-64 | 9-15 | D. Bibby 29 | D. Bibby 5 | A. Xavier 6 |
| February 15, 2026 | @ #21 Maryland Terrapins* | L 54-77 | 9-16 | C. James 14 | C. James 5 | J. Palmer 8 |
| February 20, 2026 | PENN STATE NITTANY LIONS* | L 62-75 | 9-17 | C. James 17 | D. Bibby 3 | J. Palmer 7 |
| February 22, 2026 | @ Penn State Nittany Lions* | L 51-67 | 9-18 | C. James 11 | A. Xavier 4 | J. Palmer 10 |
| February 27, 2026 | #7 MICHIGAN STATE SPARTANS* | L 54-68 | 9-19 | L. Angner 10 | D. Bibby 4 | J. Palmer 6 |
| March 1, 2026 | IOWA HAWKEYES* | W 72-61 | 10-19 | A. Xavier 13 | L. Angner 3 | A. Xavier 10 |
