| November 16, 2027 | TEXAS A&M-CC ISLANDERS | W 97-83 | 1-0 | L. Jameson 18 | L. Jameson 8 | D. McRae 9 |
| November 18, 2027 | VERMONT CATAMOUNTS | W 101-88 | 2-0 | L. Jameson 23 | L. Jameson 9 | D. Kante 11 |
| November 23, 2027 | STEPHEN F. AUSTIN LUMBERJACKS | W 104-77 | 3-0 | D. Kante 20 | L. Jameson 10 | D. Kante 7 |
| November 24, 2027 | MONTANA GRIZZLIES | W 106-78 | 4-0 | L. Jameson 23 | L. Jameson 7 | C. Richards 11 |
| November 30, 2027 | MEMPHIS TIGERS | L 84-103 | 4-1 | D. McRae 21 | L. Jameson 5 | C. Richards 5 |
| December 3, 2027 | @ Auburn Tigers | W 86-74 | 5-1 | D. Kante 21 | L. Jameson 8 | C. Richards 11 |
| December 13, 2027 | MISSOURI TIGERS | W 89-75 | 6-1 | E. Pack 16 | E. Pack 7 | L. Jameson 11 |
| December 19, 2027 | WEST GEORGIA WOLFPACK | W 85-78 | 7-1 | L. Jameson 17 | L. Jameson 5 | C. Richards 8 |
| December 22, 2027 | STETSON HATTERS | W 82-64 | 8-1 | N. Ross 12 | L. Jameson 3 | C. Richards 8 |
| December 26, 2027 | @ #19 Oregon Ducks* | L 85-89 | 8-2 | E. Pack 17 | L. Jameson 10 | D. Kante 8 |
| December 28, 2027 | #9 WISCONSIN BADGERS* | L 76-91 | 8-3 | D. Kante 21 | L. Jameson 6 | D. Kante 7 |
| January 2, 2028 | @ Southern California Trojans* | L 93-107 | 8-4 | D. Kante 18 | L. Jameson 4 | D. Kante 10 |
| January 4, 2028 | @ Northwestern Wildcats* | W 92-76 | 9-4 | C. Richards 22 | L. Jameson 10 | D. Kante 6 |
| January 9, 2028 | @ Ohio State Buckeyes* | L 72-90 | 9-5 | D. Kante 20 | E. Pack 6 | C. Richards 4 |
| January 11, 2028 | @ #2 Michigan State Spartans* | W 97-79 | 10-5 | E. Pack 22 | L. Jameson 11 | C. Richards 8 |
| January 16, 2028 | MINNESOTA GOLDEN GOPHERS* | W 99-86 | 11-5 | L. Jameson 17 | L. Jameson 5 | L. Blackwell 9 |
| January 18, 2028 | @ Maryland Terrapins* | L 81-86 | 11-6 | C. Richards 17 | L. Jameson 4 | C. Richards 9 |
| January 23, 2028 | @ Iowa Hawkeyes* | L 72-85 | 11-7 | L. Jameson 16 | L. Jameson 6 | C. Richards 8 |
| January 25, 2028 | INDIANA HOOSIERS* | L 62-71 | 11-8 | L. Jameson 16 | E. Pack 4 | D. Kante 11 |
| January 30, 2028 | PENN STATE NITTANY LIONS* | W 76-74 | 12-8 | N. Ross 23 | L. Jameson 7 | K. Lockhart 10 |
| February 1, 2028 | WASHINGTON HUSKIES* | W 93-84 | 13-8 | L. Jameson 24 | L. Jameson 6 | L. Blackwell 8 |
| February 6, 2028 | @ #14 Purdue Boilermakers* | L 75-89 | 13-9 | L. Jameson 15 | L. Jameson 4 | C. Richards 11 |
| February 8, 2028 | NEBRASKA CORNHUSKERS* | W 90-69 | 14-9 | C. Richards 18 | L. Jameson 13 | D. Kante 10 |
| February 13, 2028 | MICHIGAN WOLVERINES* | L 83-84 | 14-10 | L. Jameson 21 | E. Pack 6 | L. Jameson 7 |
| February 15, 2028 | @ UCLA Bruins* | W 87-83 | 15-10 | L. Jameson 21 | L. Jameson 4 | C. Richards 14 |
| February 20, 2028 | RUTGERS SCARLET KNIGHTS* | L 85-99 | 15-11 | L. Jameson 20 | L. Jameson 5 | C. Richards 8 |
| February 22, 2028 | @ Rutgers Scarlet Knights* | L 100-106 | 15-12 | L. Jameson 18 | L. Jameson 7 | C. Richards 9 |
| February 27, 2028 | NORTHWESTERN WILDCATS* | W 104-85 | 16-12 | D. Kante 19 | E. Pack 4 | D. Kante 10 |
| March 1, 2028 | SOUTHERN CALIFORNIA TROJANS* | W 96-89 | 17-12 | C. Richards 22 | L. Jameson 8 | D. Kante 12 |
| March 8, 2028 | MARYLAND TERRAPINS (15-16, 1-10 Away) Big 10 Tournament | - | | | | |
