| November 15, 2027 | CAL ST. FULLERTON TITANS | W 71-63 | 1-0 | J. Hendrik 21 | J. Hendrik 6 | J. Edwards 7 |
| November 18, 2027 | MARSHALL THUNDERING HERD | W 81-70 | 2-0 | T. Gaskins 14 | J. Hendrik 7 | J. Edwards 9 |
| November 22, 2027 | PURDUE-FORT WAYNE MASTODONS | W 65-58 | 3-0 | J. Hendrik 22 | J. Hendrik 7 | M. Colbert 8 |
| November 25, 2027 | ILLINOIS-CHICAGO FLAMES | W 72-65 | 4-0 | J. Edwards 14 | J. Hendrik 6 | O. Oliver 8 |
| November 29, 2027 | MONTANA GRIZZLIES | W 84-64 | 5-0 | J. Edwards 16 | J. Hendrik 7 | J. Edwards 9 |
| December 2, 2027 | IDAHO STATE BENGALS | W 83-59 | 6-0 | J. Hendrik 17 | J. Edwards 6 | J. Edwards 7 |
| December 6, 2027 | BETHUNE-COOKMAN WILDCATS | W 94-72 | 7-0 | J. Hendrik 26 | J. Edwards 8 | M. Woodley 7 |
| December 13, 2027 | @ Syracuse Orange | W 80-75 | 8-0 | J. Edwards 17 | J. Hendrik 5 | M. Woodley 11 |
| December 20, 2027 | @ Clemson Tigers | W 73-66 | 9-0 | J. Hendrik 17 | J. Hendrik 8 | M. Woodley 9 |
| December 26, 2027 | @ #21 Villanova Wildcats* | L 52-90 | 9-1 | J. Edwards 9 | J. Hendrik 4 | M. Woodley 6 |
| December 30, 2027 | #2 MARQUETTE GOLDEN EAGLES* | L 61-83 | 9-2 | J. Hendrik 15 | J. Hendrik 2 | O. Oliver 9 |
| January 2, 2028 | @ St. Johns Red Storm* | W 70-67 | 10-2 | J. Edwards 20 | J. Hendrik 6 | M. Colbert 8 |
| January 4, 2028 | DEPAUL BLUE DEMONS* | W 81-74 | 11-2 | A. Leach 17 | J. Edwards 2 | T. Gaskins 5 |
| January 6, 2028 | #24 BUTLER BULLDOGS* | W 73-69 | 12-2 | O. Oliver 14 | J. Edwards 5 | M. Colbert 5 |
| January 11, 2028 | @ Connecticut Huskies* | L 68-73 | 12-3 | J. Hendrik 20 | J. Hendrik 8 | O. Oliver 7 |
| January 13, 2028 | @ Xavier Musketeers* | L 61-65 | 12-4 | J. Edwards 14 | O. Oliver 3 | J. Edwards 8 |
| January 18, 2028 | #18 CREIGHTON BLUE JAYS* | W 80-75 | 13-4 | J. Hendrik 18 | J. Hendrik 6 | M. Colbert 5 |
| January 23, 2028 | @ DePaul Blue Demons* | L 71-78 | 13-5 | J. Hendrik 14 | J. Hendrik 7 | M. Colbert 8 |
| January 27, 2028 | SETON HALL PIRATES* | L 69-79 | 13-6 | M. Colbert 19 | J. Hendrik 4 | M. Colbert 9 |
| January 30, 2028 | PROVIDENCE FRIARS* | W 79-76 | 14-6 | M. Colbert 17 | J. Edwards 6 | J. Edwards 5 |
| February 1, 2028 | @ Butler Bulldogs* | L 61-72 | 14-7 | J. Edwards 19 | J. Hendrik 7 | J. Edwards 8 |
| February 3, 2028 | @ #1 Marquette Golden Eagles* | L 60-87 | 14-8 | O. Oliver 15 | O. Oliver 3 | M. Colbert 12 |
| February 8, 2028 | XAVIER MUSKETEERS* | W 85-67 | 15-8 | J. Hendrik 15 | J. Hendrik 7 | J. Edwards 8 |
| February 10, 2028 | CONNECTICUT HUSKIES* | W 74-56 | 16-8 | J. Hendrik 20 | J. Edwards 5 | O. Oliver 10 |
| February 15, 2028 | @ Seton Hall Pirates* | L 78-84 | 16-9 | J. Hendrik 18 | J. Hendrik 5 | J. Edwards 6 |
| February 17, 2028 | @ Providence Friars* | L 54-75 | 16-10 | J. Hendrik 11 | J. Edwards 4 | J. Edwards 6 |
| February 22, 2028 | ST. JOHNS RED STORM* | L 73-78 OT | 16-11 | T. Gaskins 17 | J. Edwards 6 | O. Oliver 9 |
| February 24, 2028 | VILLANOVA WILDCATS* | W 77-69 | 17-11 | M. Colbert 22 | J. Hendrik 4 | T. Gaskins 9 |
| March 3, 2028 | @ Creighton Blue Jays* | L 58-82 | 17-12 | A. Leach 16 | J. Hendrik 3 | J. Hendrik 9 |
| March 9, 2028 | @ Connecticut Huskies Big East Tournament | L 70-75 | 17-13 | J. Edwards 20 | J. Hendrik 8 | T. Gaskins 7 |
