| November 16, 2027 | COPPIN STATE EAGLES | W 91-74 | 1-0 | M. Kosik 20 | R. Bland 6 | T. Childs 10 |
| November 19, 2027 | NEW HAVEN CHARGERS | L 65-70 | 1-1 | J. Howell 16 | R. Bland 4 | T. Childs 14 |
| November 21, 2027 | VIRGINIA TECH HOKIES Hall of Fame Classic | W 75-72 | 2-1 | J. Fletcher 17 | R. Bland 5 | J. Fletcher 15 |
| November 22, 2027 | @ Oregon Ducks Hall of Fame Classic | L 82-89 | 2-2 | T. Childs 21 | R. Bland 7 | T. Childs 8 |
| November 30, 2027 | ARKANSAS STATE RED WOLVES | W 89-73 | 3-2 | J. Howell 20 | R. Bland 8 | T. Childs 8 |
| December 2, 2027 | ST. BONAVENTURE BONNIES | W 84-69 | 4-2 | J. Howell 21 | R. Bland 9 | T. Childs 7 |
| December 7, 2027 | WILLIAM & MARY TRIBE | W 103-85 | 5-2 | J. Howell 20 | R. Bland 7 | J. Howell 9 |
| December 10, 2027 | @ West Virginia Mountaineers | L 62-87 | 5-3 | J. Howell 14 | R. Bland 8 | T. Childs 10 |
| December 13, 2027 | @ #21 Syracuse Orange | L 73-82 | 5-4 | R. Bland 15 | M. Kosik 9 | J. Fletcher 9 |
| December 21, 2027 | MONMOUTH HAWKS | W 80-73 | 6-4 | R. Bland 13 | R. Bland 6 | R. Bland 8 |
| December 26, 2027 | ST. JOHNS RED STORM* | W 69-63 | 7-4 | M. Kosik 15 | R. Bland 8 | M. Kosik 4 |
| December 28, 2027 | @ DePaul Blue Demons* | L 77-91 | 7-5 | T. Childs 21 | R. Bland 8 | J. Fletcher 10 |
| December 30, 2027 | @ #10 Connecticut Huskies* | L 75-100 | 7-6 | M. Kosik 18 | R. Bland 6 | J. Fletcher 9 |
| January 2, 2028 | #25 MARQUETTE GOLDEN EAGLES* | W 81-74 | 8-6 | M. Kosik 20 | R. Bland 6 | J. Fletcher 10 |
| January 4, 2028 | @ Xavier Musketeers* | W 101-87 | 9-6 | M. Kosik 21 | R. Bland 7 | T. Childs 10 |
| January 9, 2028 | PROVIDENCE FRIARS* | W 103-82 | 10-6 | T. Childs 21 | R. Bland 6 | J. Fletcher 9 |
| January 13, 2028 | BUTLER BULLDOGS* | W 83-54 | 11-6 | M. Kosik 17 | R. Bland 14 | T. Childs 10 |
| January 18, 2028 | @ Seton Hall Pirates* | L 54-71 | 11-7 | J. Howell 12 | R. Bland 4 | J. Howell 8 |
| January 20, 2028 | @ #12 Creighton Blue Jays* | W 76-63 | 12-7 | J. Fletcher 17 | R. Bland 7 | J. Fletcher 14 |
| January 25, 2028 | @ Providence Friars* | W 95-84 | 13-7 | J. Fletcher 17 | R. Bland 6 | T. Childs 11 |
| January 27, 2028 | @ Villanova Wildcats* | L 80-93 | 13-8 | A. Shin 15 | R. Bland 9 | T. Childs 8 |
| February 1, 2028 | XAVIER MUSKETEERS* | W 103-85 | 14-8 | T. Childs 25 | S. Smith 11 | T. Childs 8 |
| February 3, 2028 | @ Butler Bulldogs* | W 77-70 | 15-8 | M. Kosik 17 | R. Bland 4 | J. Fletcher 7 |
| February 8, 2028 | #13 CREIGHTON BLUE JAYS* | L 56-86 | 15-9 | M. Kosik 15 | R. Bland 9 | T. Childs 9 |
| February 10, 2028 | SETON HALL PIRATES* | W 76-73 | 16-9 | M. Kosik 27 | R. Bland 4 | J. Howell 9 |
| February 17, 2028 | VILLANOVA WILDCATS* | W 80-58 | 17-9 | J. Howell 18 | R. Bland 8 | T. Childs 8 |
| February 22, 2028 | @ #21 Marquette Golden Eagles* | L 83-98 | 17-10 | J. Howell 20 | R. Bland 5 | J. Fletcher 8 |
| February 24, 2028 | @ St. Johns Red Storm* | L 79-90 | 17-11 | R. Bland 16 | A. Shin 7 | T. Childs 6 |
| March 1, 2028 | #9 CONNECTICUT HUSKIES* | L 86-105 | 17-12 | R. Bland 17 | R. Bland 8 | J. Fletcher 7 |
| March 3, 2028 | DEPAUL BLUE DEMONS* | W 85-72 | 18-12 | M. Kosik 19 | R. Bland 5 | T. Childs 10 |
| March 10, 2028 | PROVIDENCE FRIARS (16-13, 7-5 Away) Big East Tournament | - | | | | |
