| November 15, 2027 | @ Rutgers Scarlet Knights | W 83-60 | 1-0 | D. Dennis 17 | J. Dowling 8 | B. Hatcher 11 |
| November 18, 2027 | @ Mississippi State Bulldogs | L 80-83 | 1-1 | J. Yarbrough 17 | J. Dowling 3 | B. Hatcher 6 |
| November 22, 2027 | COLUMBIA LIONS | W 87-67 | 2-1 | J. Yarbrough 25 | J. Dowling 9 | D. Dennis 12 |
| November 29, 2027 | GEORGIA SOUTHERN EAGLES | W 86-75 | 3-1 | J. Yarbrough 26 | J. Dowling 7 | D. Dennis 11 |
| December 6, 2027 | HAWAII RAINBOW WARRIORS | W 90-77 | 4-1 | J. Yarbrough 16 | J. Dowling 11 | D. Dennis 6 |
| December 9, 2027 | PRINCETON TIGERS Cayman Islands Classic | W 88-87 | 5-1 | J. Yarbrough 20 | T. Kerr 5 | D. Dennis 10 |
| December 10, 2027 | MISSISSIPPI STATE BULLDOGS Cayman Islands Classic | W 83-63 | 6-1 | D. Dennis 18 | J. Yarbrough 7 | C. Dyer 8 |
| December 11, 2027 | @ #19 UCLA Bruins Cayman Islands Classic | W 68-52 | 7-1 | J. Yarbrough 22 | J. Dowling 6 | D. Dennis 15 |
| December 13, 2027 | SOUTH DAKOTA STATE JACKRABBITS | W 81-68 | 8-1 | J. Yarbrough 22 | T. Kerr 7 | D. Dennis 12 |
| December 20, 2027 | @ Providence Friars | L 58-65 | 8-2 | J. Yarbrough 21 | J. Dowling 6 | D. Dennis 9 |
| December 24, 2027 | WEST GEORGIA WOLFPACK | W 83-76 | 9-2 | J. Yarbrough 15 | T. Kerr 7 | D. Dennis 10 |
| December 26, 2027 | SOUTHERN METHODIST MUSTANGS* | W 83-67 | 10-2 | J. Yarbrough 25 | J. Dowling 9 | D. Dennis 13 |
| December 28, 2027 | @ California Golden Bears* | L 86-96 | 10-3 | J. Dowling 15 | J. Dowling 7 | B. Hatcher 11 |
| January 2, 2028 | MIAMI (FL) HURRICANES* | W 95-90 | 11-3 | D. Dennis 17 | J. Dowling 3 | R. Malone 7 |
| January 4, 2028 | @ #9 Duke Blue Devils* | L 72-84 | 11-4 | J. Yarbrough 20 | J. Dowling 3 | D. Dennis 11 |
| January 9, 2028 | VIRGINIA TECH HOKIES* | W 93-88 | 12-4 | D. Dennis 22 | R. Malone 4 | B. Hatcher 7 |
| January 11, 2028 | @ Notre Dame Fighting Irish* | L 76-91 | 12-5 | J. Yarbrough 32 | J. Dowling 7 | D. Dennis 10 |
| January 16, 2028 | #12 NORTH CAROLINA TAR HEELS* | W 78-63 | 13-5 | J. Yarbrough 24 | J. Dowling 9 | R. Malone 8 |
| January 18, 2028 | @ Stanford Cardinal* | W 66-56 | 14-5 | J. Yarbrough 20 | J. Dowling 4 | D. Dennis 14 |
| January 23, 2028 | @ #14 Pittsburgh Panthers* | L 76-80 | 14-6 | J. Yarbrough 21 | J. Yarbrough 6 | D. Dennis 12 |
| January 25, 2028 | @ Florida State Seminoles* | W 85-74 | 15-6 | D. Dennis 21 | J. Dowling 8 | D. Dennis 11 |
| January 30, 2028 | @ #9 Louisville Cardinals* | W 73-64 | 16-6 | J. Yarbrough 15 | J. Dowling 5 | D. Dennis 11 |
| February 1, 2028 | NC-STATE WOLFPACK* | W 79-46 | 17-6 | J. Dowling 22 | J. Dowling 6 | L. Goree 9 |
| February 6, 2028 | SYRACUSE ORANGE* | W 91-70 | 18-6 | J. Yarbrough 20 | J. Dowling 4 | D. Dennis 14 |
| February 8, 2028 | CLEMSON TIGERS* | W 71-59 | 19-6 | J. Yarbrough 22 | J. Dowling 6 | R. Malone 13 |
| February 13, 2028 | WAKE FOREST DEMON DEACONS* | W 87-78 | 20-6 | J. Yarbrough 25 | J. Dowling 10 | C. Dyer 10 |
| February 15, 2028 | @ #7 Virginia Cavaliers* | W 98-95 OT | 21-6 | L. Goree 19 | J. Yarbrough 5 | D. Dennis 12 |
| February 20, 2028 | @ Boston College Eagles* | W 93-80 | 22-6 | J. Yarbrough 29 | J. Dowling 8 | B. Hatcher 6 |
| February 22, 2028 | @ Clemson Tigers* | W 82-62 | 23-6 | J. Yarbrough 22 | J. Dowling 9 | D. Dennis 10 |
| February 27, 2028 | FLORIDA STATE SEMINOLES* | W 78-60 | 24-6 | J. Yarbrough 27 | J. Dowling 5 | D. Dennis 9 |
| March 1, 2028 | #10 VIRGINIA CAVALIERS* | L 72-78 | 24-7 | J. Yarbrough 16 | J. Dowling 7 | D. Dennis 11 |
| March 10, 2028 | #15 PITTSBURGH PANTHERS ACC Tournament | L 69-101 | 24-8 | D. Dennis 17 | J. Yarbrough 4 | D. Dennis 9 |
