| November 15, 2027 | DEPAUL BLUE DEMONS | L 73-89 | 0-1 | J. Block 18 | D. Hedrick 3 | G. Montague 7 |
| November 18, 2027 | SOUTHERN ILLINOIS SALUKIS | W 82-81 | 1-1 | J. Block 13 | D. Hedrick 4 | J. Block 9 |
| November 22, 2027 | VALPARAISO BEACONS | W 67-57 | 2-1 | J. Block 11 | D. Hedrick 6 | J. Block 12 |
| November 25, 2027 | EASTERN WASHINGTON EAGLES | W 79-65 | 3-1 | L. Benton 22 | D. Hedrick 5 | J. Block 12 |
| November 29, 2027 | OHIO BOBCATS | W 74-68 | 4-1 | J. Layne 16 | D. Hedrick 4 | B. Forman 6 |
| December 6, 2027 | #18 TEXAS LONGHORNS | L 55-69 | 4-2 | L. Benton 11 | D. Hedrick 2 | J. Block 8 |
| December 9, 2027 | NEBRASKA CORNHUSKERS Jimmy V Classic | W 94-67 | 5-2 | J. Block 25 | D. Hedrick 7 | J. Block 6 |
| December 10, 2027 | @ Houston Cougars Jimmy V Classic | W 79-72 | 6-2 | J. Layne 15 | D. Harris 4 | G. Montague 9 |
| December 11, 2027 | @ Washington State Cougars Jimmy V Classic | L 61-72 | 6-3 | A. Cotton 13 | D. Hedrick 3 | J. Chappel 7 |
| December 13, 2027 | #7 FLORIDA GATORS | W 86-81 | 7-3 | B. Forman 14 | B. Forman 4 | J. Block 5 |
| December 20, 2027 | CALIFORNIA BAPTIST LANCERS (4-5, 1-3 Away) | - | | | | |
| December 26, 2027 | @ North Carolina Tar Heels (9-1, 0-0, 6-1 Home)* | - | | | | |
| December 28, 2027 | @ Wake Forest Demon Deacons (6-2, 0-0, 6-0 Home)* | - | | | | |
| January 2, 2028 | CLEMSON TIGERS (7-2, 0-0, 0-0 Away)* | - | | | | |
| January 4, 2028 | NC-STATE WOLFPACK (5-2, 0-0, 0-0 Away)* | - | | | | |
| January 9, 2028 | STANFORD CARDINAL (6-2, 0-0, 0-1 Away)* | - | | | | |
| January 11, 2028 | PITTSBURGH PANTHERS (9-2, 0-0, 0-1 Away)* | - | | | | |
| January 16, 2028 | @ Virginia Cavaliers (9-1, 0-0, 4-0 Home)* | - | | | | |
| January 18, 2028 | BOSTON COLLEGE EAGLES (5-4, 0-0, 0-2 Away)* | - | | | | |
| January 23, 2028 | VIRGINIA TECH HOKIES (5-3, 0-0, 0-1 Away)* | - | | | | |
| January 25, 2028 | GEORGIA TECH YELLOW JACKETS (8-1, 0-0, 1-1 Away)* | - | | | | |
| January 30, 2028 | @ Notre Dame Fighting Irish (5-4, 0-0, 4-3 Home)* | - | | | | |
| February 1, 2028 | @ Southern Methodist Mustangs (4-4, 0-0, 3-3 Home)* | - | | | | |
| February 6, 2028 | CALIFORNIA GOLDEN BEARS (5-3, 0-0, 1-0 Away)* | - | | | | |
| February 8, 2028 | @ Duke Blue Devils (6-4, 0-0, 4-1 Home)* | - | | | | |
| February 13, 2028 | @ Miami (FL) Hurricanes (5-2, 0-0, 5-0 Home)* | - | | | | |
| February 15, 2028 | SYRACUSE ORANGE (3-5, 0-0, 0-0 Away)* | - | | | | |
| February 20, 2028 | LOUISVILLE CARDINALS (8-1, 0-0, 1-0 Away)* | - | | | | |
| February 22, 2028 | @ Syracuse Orange (3-5, 0-0, 3-4 Home)* | - | | | | |
| February 27, 2028 | @ Georgia Tech Yellow Jackets (8-1, 0-0, 4-0 Home)* | - | | | | |
| March 1, 2028 | @ NC-State Wolfpack (5-2, 0-0, 5-2 Home)* | - | | | | |
