| November 15, 2027 | DEPAUL BLUE DEMONS | L 73-89 | 0-1 | J. Block 18 | D. Hedrick 3 | G. Montague 7 |
| November 18, 2027 | SOUTHERN ILLINOIS SALUKIS | W 82-81 | 1-1 | J. Block 13 | D. Hedrick 4 | J. Block 9 |
| November 22, 2027 | VALPARAISO BEACONS | W 67-57 | 2-1 | J. Block 11 | D. Hedrick 6 | J. Block 12 |
| November 25, 2027 | EASTERN WASHINGTON EAGLES | W 79-65 | 3-1 | L. Benton 22 | D. Hedrick 5 | J. Block 12 |
| November 29, 2027 | OHIO BOBCATS | W 74-68 | 4-1 | J. Layne 16 | D. Hedrick 4 | B. Forman 6 |
| December 6, 2027 | #18 TEXAS LONGHORNS | L 55-69 | 4-2 | L. Benton 11 | D. Hedrick 2 | J. Block 8 |
| December 9, 2027 | NEBRASKA CORNHUSKERS Jimmy V Classic | W 94-67 | 5-2 | J. Block 25 | D. Hedrick 7 | J. Block 6 |
| December 10, 2027 | @ Houston Cougars Jimmy V Classic | W 79-72 | 6-2 | J. Layne 15 | D. Harris 4 | G. Montague 9 |
| December 11, 2027 | @ Washington State Cougars Jimmy V Classic | L 61-72 | 6-3 | A. Cotton 13 | D. Hedrick 3 | J. Chappel 7 |
| December 13, 2027 | #7 FLORIDA GATORS | W 86-81 | 7-3 | B. Forman 14 | B. Forman 4 | J. Block 5 |
| December 20, 2027 | CALIFORNIA BAPTIST LANCERS | W 69-54 | 8-3 | J. Block 25 | D. Harris 3 | G. Montague 14 |
| December 26, 2027 | @ #11 North Carolina Tar Heels* | L 47-73 | 8-4 | J. Block 10 | J. Block 2 | J. Block 11 |
| December 28, 2027 | @ Wake Forest Demon Deacons* | L 70-79 | 8-5 | G. Montague 14 | D. Hedrick 6 | J. Block 5 |
| January 2, 2028 | CLEMSON TIGERS* | W 70-66 | 9-5 | J. Dillon 14 | D. Hedrick 6 | J. Block 8 |
| January 4, 2028 | NC-STATE WOLFPACK* | L 61-73 | 9-6 | L. Benton 11 | B. Forman 2 | G. Montague 9 |
| January 9, 2028 | STANFORD CARDINAL* | L 65-67 | 9-7 | L. Benton 16 | J. Block 5 | B. Forman 12 |
| January 11, 2028 | #16 PITTSBURGH PANTHERS* | L 76-79 | 9-8 | L. Benton 14 | D. Hedrick 3 | J. Block 10 |
| January 16, 2028 | @ #5 Virginia Cavaliers* | L 56-72 | 9-9 | J. Chambers 17 | D. Hedrick 4 | J. Block 13 |
| January 18, 2028 | BOSTON COLLEGE EAGLES* | W 86-85 OT | 10-9 | J. Block 20 | D. Hedrick 7 | B. Forman 9 |
| January 23, 2028 | VIRGINIA TECH HOKIES* | L 70-77 | 10-10 | J. Layne 13 | D. Hedrick 7 | J. Block 7 |
| January 25, 2028 | GEORGIA TECH YELLOW JACKETS* | L 74-85 | 10-11 | J. Block 24 | D. Hedrick 5 | B. Forman 8 |
| January 30, 2028 | @ Notre Dame Fighting Irish* | L 56-68 | 10-12 | L. Benton 16 | D. Hedrick 4 | J. Block 9 |
| February 1, 2028 | @ Southern Methodist Mustangs* | W 86-62 | 11-12 | L. Benton 20 | D. Hedrick 5 | B. Forman 7 |
| February 6, 2028 | CALIFORNIA GOLDEN BEARS* | W 72-62 | 12-12 | J. Block 22 | L. Benton 3 | J. Block 13 |
| February 8, 2028 | @ #9 Duke Blue Devils* | W 74-68 | 13-12 | L. Benton 14 | D. Hedrick 4 | J. Layne 7 |
| February 13, 2028 | @ Miami (FL) Hurricanes* | L 71-78 | 13-13 | L. Benton 15 | D. Hedrick 3 | J. Block 9 |
| February 15, 2028 | SYRACUSE ORANGE* | W 80-78 | 14-13 | D. Harris 19 | D. Hedrick 6 | J. Block 9 |
| February 20, 2028 | #13 LOUISVILLE CARDINALS* | W 71-59 | 15-13 | L. Benton 16 | J. Block 4 | G. Montague 7 |
| February 22, 2028 | @ Syracuse Orange* | W 79-71 | 16-13 | J. Chambers 19 | D. Hedrick 8 | J. Block 7 |
| February 27, 2028 | @ #12 Georgia Tech Yellow Jackets* | L 60-78 | 16-14 | J. Block 15 | G. Montague 3 | J. Block 10 |
| March 1, 2028 | @ NC-State Wolfpack* | L 57-70 | 16-15 | J. Block 12 | J. Chambers 2 | J. Block 14 |
| March 8, 2028 | BOSTON COLLEGE EAGLES ACC Tournament | W 76-72 OT | 17-15 | L. Benton 14 | L. Benton 5 | D. Hedrick 9 |
| March 9, 2028 | @ #15 Pittsburgh Panthers ACC Tournament | L 62-71 | 17-16 | J. Block 15 | D. Hedrick 3 | J. Block 11 |
